The effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia: A systematic review and meta-analysis

Cheng, Calvin Pak-Wing; Louie, Larissa Lok Chi; Wong, Yiu Lung; Wong, S.M.; Leung, Wing Yin; Nitsche, Michael A.; Chan, Wai Chi

doi:10.1016/j.ajp.2020.102392

Cited by 32 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We summarized the targets used in the previous NIBS studies in SCZ from several systematic reviews (8,(25)(26)(27) in Table 3. The left dlPFC and the left TPJ were the most frequency targets used in the rTMS and tDCS.…”

Section: Previous Nibs Studies In Sczmentioning

confidence: 99%

Potential Locations for Non-Invasive Brain Stimulation in Treating Schizophrenia: A Resting-State Functional Connectivity Analysis

et al. 2021

View full text Add to dashboard Cite

Introduction: Non-invasive brain stimulation (NIBS) techniques have been widely used for the purpose of improving clinical symptoms of schizophrenia. However, the ambiguous stimulation targets may limit the efficacy of NIBS for schizophrenia. Exploring effective stimulation targets may improve the clinical efficacy of NIBS in schizophrenia.Methods: We first conducted a neurosynth-based meta-analysis of 715 functional magnetic resonance imaging studies to identify schizophrenia-related brain regions as regions of interest. Then, we performed the resting-state functional connectivity analysis in 32 patients with first-episode schizophrenia to find brain surface regions correlated with the regions of interest in three pipelines. Finally, the 10–20 system coordinates corresponding to the brain surface regions were considered as potential targets for NIBS.Results: We identified several potential targets of NIBS, including the bilateral dorsal lateral prefrontal cortex, supplementary motor area, bilateral inferior parietal lobule, temporal pole, medial prefrontal cortex, precuneus, superior and middle temporal gyrus, and superior and middle occipital gyrus. Notably, the 10-20 system location of the bilateral dorsal lateral prefrontal cortex was posterior to F3 (F4), not F3 (F4).Conclusion: Conclusively, our findings suggested that the stimulation locations corresponding to these potential targets might help clinicians optimize the application of NIBS therapy in individuals with schizophrenia.

show abstract

Section: Previous Nibs Studies In Sczmentioning

confidence: 99%

Potential Locations for Non-Invasive Brain Stimulation in Treating Schizophrenia: A Resting-State Functional Connectivity Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The anode was mainly positioned at the DLPFC, and the cathode was positioned mostly at the temporoparietal junction. Results show that positive e and negative symptoms as well as auditory hallucination improved following stimulation [102]. Recently Hansbauer and colleagues (2020) reviewed studies concerning the use of tDCS and repetitive TMS for the treatment of catatonia e a syndrome observed in schizophrenia.…”

Section: Clinical Trialsmentioning

confidence: 99%

Using cortical non-invasive neuromodulation as a potential preventive treatment in schizophrenia - A review

2021

View full text Add to dashboard Cite

Background: Evidence suggests that schizophrenia constitutes a neurodevelopmental disorder, characterized by a gradual emergence of behavioral and neurobiological abnormalities over time. Therefore, applying early interventions to prevent later manifestation of symptoms is appealing. Objective: This review focuses on the use of cortical neuromodulation in schizophrenia and its potential as a preventive treatment approach. We present clinical and preclinical findings investigating the use of neuromodulation in schizophrenia, including the current research focusing on cortical non-invasive stimulation and its possibility as a future preventive treatment. Methods: We performed a search in Medline (PubMed) in September 2020 using a combination of relevant medical subject headings (MeSH) and text words. The search included human and preclinical trials as well as existing systematic reviews and meta-analysis. There were no restrictions on language or the date of publication.Results: Neurodevelopmental animal models may be used to investigate how the disease progresses and thus which brain areas ideally should be targeted at a given time point. Here, abnormalities of the prefrontal cortex have been often identified as an early and persistent impairment in schizophrenia. Currently there is insufficient evidence to either support or refute the use of neuromodulation to the cortex in adult patients with already manifested symptoms. However, preclinical results show that early non-invasive neuromodulation to the prefrontal cortex of adolescent animals, sufficiently prevents later psychosis-relevant abnormalities in adulthood. This points to the promising potential of cortical noninvasive neuromodulation as a preventive treatment when applied early in the course of the disease. Conclusion: Preclinical translational-oriented findings indicate, that neuromodulation to cortical areas offers the possibility of targeting early neuropathology and through this diminish the progression of a later schizophrenic profile. Further studies are needed to investigate whether such early cortical stimulation may serve as a future preventive treatment in schizophrenia.

show abstract

“…In adults (pregnant women excluded) suffering from unipolar or bipolar depression, a recent meta-analysis based upon 23 randomized controlled trials (RCT) (1092 patients) demonstrated that tDCS (anodal stimulation of the left dorsolateral prefrontal cortex (F3), current intensity mostly at 2 mA, on 25 to 35 cm 2 sponges, 20 to 30 min of stimulation over 5 to 20 sessions) had superior efficacy to placebo stimulation with a respective response rate of 33.3% versus 16.56% (OR: 2.28, 1.52 to 3.42), and a remission rate of 19.12% versus 9.78% (OR: 2.12, 1.42 to 3.16) [ 31 ]. Concerning patients suffering from schizophrenia, another recent meta-analysis based on 16 RCT (326 patients) demonstrated that adjuvant tDCS (anodal stimulation of the left dorsolateral prefrontal cortex (F3); cathodal stimulation at the left temporoparietal–parietal junction (T3P3); the current intensity at 2 mA; on sponges of 25 to 35 cm 2 ; 20 min of stimulation over 5 to 40 sessions) was more effective than placebo stimulation on positive symptoms (standard mean difference (SMD): 0.17, 95% CI: 0.001 to 0.33), negative symptoms (SMD: 0.43, 95% CI: 0.11 to 0.75), and auditory hallucinations (SMD: 0.36, 95% CI: 0.02 to 0.70) [ 32 ]. For PTSD, tDCS was used—adjuvant to medication [ 33 ] or in association with virtual reality exposure [ 34 ]—to enhance fear extinction by stimulating the prefrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports

Laurin

Nard

Dalmont

et al. 2022

JCM

View full text Add to dashboard Cite

Introduction: The perinatal period is an at-risk period for the emergence or decompensation of psychiatric disorders. Transcranial electrical stimulation (tES) is an effective and safe treatment for many psychiatric disorders. Given the reluctance to use pharmacological treatments during pregnancy or breastfeeding, tES may be an interesting treatment to consider. Our study aims to evaluate the efficacy and safety of tES in the perinatal period through a systematic literature review followed by three original case reports. Method: Following PRISMA guidelines, a systematic review of MEDLINE and ScienceDirect was undertaken to identify studies on tES on women during the perinatal period. The initial research was conducted until 31 December 2021 and search terms included: tDCS, transcranial direct current stimulation, tACS, transcranial alternating current stimulation, tRNS, transcranial random noise stimulation, pregnancy, perinatal, postnatal, and postpartum. Results: Seven studies reporting on 33 women during the perinatal period met the eligibility criteria. No serious adverse effects for the mother or child were reported. Data were limited to the use of tES during pregnancy in patients with schizophrenia or unipolar depression. In addition, we reported three original case reports illustrating the efficacy and safety of tDCS: in a pregnant woman with bipolar depression, in a pregnant woman with post-traumatic stress disorder (sham tDCS), and in a breastfeeding woman with postpartum depression. Conclusions: The results are encouraging, making tES a potentially safe and effective treatment in the perinatal period. Larger studies are needed to confirm these initial results, and any adverse effects on the mother or child should be reported. In addition, research perspectives on the medico-economic benefits of tES, and its realization at home, are to be investigated in the future.

show abstract

The effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia: A systematic review and meta-analysis

Cited by 32 publications

References 31 publications

Potential Locations for Non-Invasive Brain Stimulation in Treating Schizophrenia: A Resting-State Functional Connectivity Analysis

Potential Locations for Non-Invasive Brain Stimulation in Treating Schizophrenia: A Resting-State Functional Connectivity Analysis

Using cortical non-invasive neuromodulation as a potential preventive treatment in schizophrenia - A review

Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports

Contact Info

Product

Resources

About