The effects of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure, cerebral and cardiac hemodynamics, and plasma nitric oxide levels in acute stroke

Rashid, Parveen A.; Weaver, Chris; Leonardi‐Bee, Jo; Bath, F J; Fletcher, Sally; Bath, Philip M

doi:10.1016/s1052-3057(03)00037-5

Cited by 74 publications

(123 citation statements)

References 32 publications

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“…10,11 Indirect evidence also suggested that nitrates lowered BP without attenuating CBF, confirming preclinical data. 12-14 Sodium nitroprusside did not alter CBF, assessed qualitatively using single-photon emission computed tomography.…”

supporting

confidence: 55%

“…21 Duplicate mean, systolic, and diastolic velocities and pulsatility index were measured separately for affected and unaffected hemispheres. 10,11 BP was measured immediately before the baseline xenon CT scan and immediately after the posttreatment scan. Duplicate measurements of peripheral systolic and diastolic BP were measured in the nonhemiparetic arm with a validated digital readout oscillometric device (Omron HEM-705CP, Omron Corp).…”

Section: Methodsmentioning

confidence: 99%

“…22 Central BP was assessed by applanation tonometry of the left radial artery and using the Pulse Wave Analysis system (Sphygmocor). 11 Duplicate recordings were taken, composed of a screen of data satisfying the quality control criteria of the Pulse Wave Analysis system (pulse height and diastolic variability Յ10%). The recorded radial artery pressure wave was transformed to the corresponding central wave using a validated transfer function and central BP derived automatically.…”

Section: Methodsmentioning

confidence: 99%

“…15 Similarly, GTN did not change the middle cerebral artery blood velocity and pulsatility index, these being indirect measures of CBF. 11 The aim of the present study was to assess simultaneously the effects of GTN on BP, CBF, and CPP.…”

mentioning

confidence: 99%

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Transdermal Glyceryl Trinitrate Lowers Blood Pressure and Maintains Cerebral Blood Flow in Recent Stroke

et al. 2006

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Abstract-High blood pressure (BP) is common in acute stroke and is independently associated with a poor outcome.Lowering BP might improve outcome if it did not adversely affect cerebral blood flow (CBF) or cerebral perfusion pressure. We investigated the effect of glyceryl trinitrate ([GTN] an NO donor) on quantitative CBF, BP, and cerebral perfusion pressure in patients with recent stroke. Eighteen patients with recent (Ͻ5 days) ischemic (nϭ16) or hemorrhagic (nϭ2) stroke were randomly assigned (2:1) to transdermal GTN (5 mg) or control. CBF (global, hemispheric, arterial territory, and lesion, using xenon computed tomography) and BP (peripheral and central) were measured before and 1 hour after treatment with GTN. The effects of GTN on CBF and BP were adjusted for baseline measurements (ANCOVA

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supporting

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Transdermal Glyceryl Trinitrate Lowers Blood Pressure and Maintains Cerebral Blood Flow in Recent Stroke

et al. 2006

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“…[11][12][13] A non randomised comparison of intravenous sodium nitroprusside in patients with acute ischaemic stroke and normal older volunteers was excluded. [18] The trials included a total of 145 patients (NO donor 93, control 52) and each assessed transdermal glyceryl trinitrate (GTN), an organic nitrate.…”

Section: Trial Characteristicsmentioning

confidence: 99%