The Effects of Transpositional Muscle Flaps Transfected with Vascular Endothelial Growth Factor Gene in the Treatment of Experimental Osteomyelitis

Aliyev, Mahir; Aykan, Andaç; Eski, Muhitdin; Arslan, Nuri; Kurt, Bülent; Şengezer, Mustafa

doi:10.5505/tjtes.2015.37888

Cited by 1 publication

(1 citation statement)

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“…Several therapies intended to enhance blood flow to vascular or chronically infected areas have been tested in experimental models or clinical trials, including hyperbaric oxygen therapy, PRP, and VEGF delivery [ 47 – 49 ]. Recently, a VEGF gene-transfected muscle flap was shown to be effective as a treatment to supplement systemic antibiotic treatment in the management of experimental OM in a rodent model [ 50 , 51 ]. These strategies seek to enhance the body’s own defense and the effectiveness of antibiotics by enhancing blood flow to avascular tissue.…”

Section: Introductionmentioning

confidence: 99%

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

et al. 2018

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The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, osteoarthritis, osteomyelitis, etc.), to develop effective therapeutic drug screening, and to test potential therapeutic strategies. Dysregulated interactions between vasculature and bone cells are often related to the aforementioned pathologies, underscoring the need for a bone model that contains engineered vasculature. Due to ethical restraints and limited prediction power of animal models, human stem cell-based tissue engineering has gained increasing relevance as a candidate approach to overcome the limitations of animals and to serve as preclinical models for drug testing. Since bone is a highly vascularized tissue, the concomitant development of vasculature and mineralized matrix requires a synergistic interaction between osteogenic and endothelial precursors. A number of experimental approaches have been used to achieve this goal, such as the combination of angiogenic factors and three-dimensional scaffolds, prevascularization strategies, and coculture systems. In this review, we present an overview of the current models and approaches to generate in-vitro stem cell-based vascularized bone, with emphasis on the main challenges of vasculature engineering. These challenges are related to the choice of biomaterials, scaffold fabrication techniques, and cells, as well as the type of culturing conditions required, and specifically the application of dynamic culture systems using bioreactors.

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Section: Introductionmentioning

confidence: 99%

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

et al. 2018

View full text Add to dashboard Cite

show abstract

The Effects of Transpositional Muscle Flaps Transfected with Vascular Endothelial Growth Factor Gene in the Treatment of Experimental Osteomyelitis

Abstract: BACKGROUND: Based on the angiogenetic and stimulating effects of bone healing and formation of vascular endothelial growth factor (VEGF), the present study was designed to assess the efficacy of VEGF gene application in the management of experimentally induced osteomyelitis.

Cited by 1 publication

References 29 publications

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

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