The effects of trazodone on sleep in patients treated with stimulant antidepressants

Kaynak, Hakan; Kaynak, Derya; Gözükırmızı, Erbil; Guilleminault, Christian

doi:10.1016/j.sleep.2003.06.006

Cited by 109 publications

(68 citation statements)

References 11 publications

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“…Nierenberg and colleagues reported good in subjective sleep parameters (PSQI -Pittsburgh Index) with the use of 50 mg/day of trazodone while evaluating patients with secondary insomnia with the use of antidepressants 24 . Similar findings were observed by Kaynak using trazodone at a dose of 100 mg/day, with subjective and objective improvement of quality of sleep after one week of treatment 10 . Despite the improvement in sleep parameters reported in most studies, polysomnographic findings vary among studies, probably due to differences in the dose used and age of the participants (Table 3).…”

Section: Discussionsupporting

confidence: 85%

“…In our study, the patients did not use trazodone at doses higher than 100 mg/day, which may have contributed to a lower effectiveness when compared to mirtazapine. There appears to be some improvement in sleep parameters with increasing doses of trazodone 6,7,10 . Nierenberg and colleagues reported good in subjective sleep parameters (PSQI -Pittsburgh Index) with the use of 50 mg/day of trazodone while evaluating patients with secondary insomnia with the use of antidepressants 24 .…”

Section: Discussionmentioning

confidence: 96%

“…It is not known whether there is an improvement in sleep due to an improvement in depression or whether the improved sleep is due to the direct action of the medication 11 . Kaynak and collaborators suggest that the therapeutic effect of trazodone on sleep is independent of its antidepressant effect 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Trazodone has proved to be effective in the treatment of sleep disorders in depressed patients (not always older) [6][7][8] , in secondary sleep disorders when compared to other substances 9,10 and in healthy individuals 11 . Assessments of the clinical response to trazodone hydrochloride for the treatment of sleep disorders in demented patients may contribute to the pool of therapeutic options for these patients.…”

mentioning

confidence: 99%

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Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study

Camargos¹,

Pandolfi²,

Freitas

et al. 2011

Arq. Neuro-Psiquiatr.

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Sleep disorders (SD) in patients with dementia are very common in clinical practice. The use of antidepressants with hypnotic actions, such as trazodone, plays an important role in these cases. The aim of this study is to present a profile of the use of trazodone in demented patients with SD, as well as a review of trazodone hydrochloride in SD. We evaluated 178 elderly patients with Alzheimer's disease and other dementias, clinically presenting SD and treated with hypnosedative medications. In the one-year period comprising the study, 68 (38.2%) of the 178 had sleep disorders. Most patients (114; 64%) had a diagnosis of Alzheimer's disease. Approximately 85% of patients with SD used hypnosedative drugs. Trazodone was the most commonly used drug among patients (N = 35), with an effectiveness of 65.7%. Trazodone has been shown to be a good option for treatment of the elderly with dementia and associated SD. Key words: sleep, dementia, Alzheimer's disease, trazodone, antidepressant.Trazodona para o tratamento de distúrbios do sono em demência: um estudo aberto, observacional e de revisão RESUMO Distúrbios do sono (DS) em pacientes com demência são muito comuns na prática clínica. O uso de antidepressivos com ação hipnótica, como a trazodona, tem um papel importante nesses casos. O objetivo desse estudo é apresentar um perfil do uso da trazodona em pacientes com demência e com DS, bem como revisar o cloridrato de trazodona no DS. Nós avaliamos 178 idosos com doença de Alzheimer (DA) e outras demências, clinicamente apresentando DS e que foram tratados com medicações hipnossedativas. No período de um ano de estudo, 68 (38,2%) tiveram DS. A maioria (114; 64%) tinham diagnóstico de DA. Aproximadamente 85% usaram fármacos hipnossedativos. A trazodona foi a mais utilizada (N=35), com evidência de melhora de 65,7%. A trazodona mostrou-se ser uma boa opção no tratamento de idosos com demência e DS associado. Palavras-chave: sono, demência, doença de Alzheimer, trazodona, antidepressivos.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study

Camargos¹,

Pandolfi²,

Freitas

et al. 2011

Arq. Neuro-Psiquiatr.

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“…Trazodone is likely effective acutely in the treatment of depressed patients with insomnia. [70][71][72][73] It has been used safely in several samples of alcoholics. 65,74 Liebowitz & El-Mallakh 75 posited that trazodone facilitated abstinence in alcoholics by reducing anxiety and insomnia.…”

Section: Benzodiazepines and Benzodiazepine Receptor Agonists (Bzras)-mentioning

confidence: 99%

Treatment Options for Sleep Disturbances During Alcohol Recovery

Arnedt

Conroy

Brower

2007

Journal of Addictive Diseases

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Sleep disturbances are extremely common in the early stages of recovery from alcohol dependence and may persist for several months despite continued abstinence. Studies indicate that sleep disturbances independently increase the risk for relapse to alcohol, suggesting that targeting these problems during recovery may support continued abstinence. However, there is limited information in the addiction literature about available and effective treatments for sleep disturbances in recovering alcoholic patients. The primary goals of this article are to describe the phenomenology of sleep disturbances during recovery from alcohol dependence, to outline the evidence linking sleep problems with alcohol relapse, and to describe available pharmacological and nonpharmacological treatment options, including the evidence regarding their efficacy in recovering alcoholic patients. Recommendations for future research are provided along with special considerations for treating insomnia in this population, including avoiding cross-dependent sedatives, such as benzodiazepines and benzodiazepine receptor agonists (BzRAs). alcohol; alcoholism; sleep; insomnia; treatment; pharmacological; nonpharmacological; cognitivebehavioral treatment Insomnia is a complaint of difficulties falling asleep, frequent and/or prolonged awakenings, and/or consistently unrefreshing sleep that occurs despite adequate sleep opportunity. Insomnia is exceedingly common: as many as 1/3 of adults report experiencing persistent insomnia symptoms during the year. [1][2][3][4] Insomnia symptoms persisting for more than one month that are associated with daytime impairment and/or psychological distress define an insomnia disorder, which occurs in one in ten individuals. Persistent insomnia is associated with wide ranging adverse consequences, including decreased quality of life, increased risk for psychiatric disturbances, increased work absenteeism, and poor interpersonal functioning. 1,2,5,6 Among patients in recovery from alcohol dependence, insomnia complaints are especially frequent and may persist for weeks to months post-abstinence. [7][8][9][10][11][12][13][14] Of particular importance, untreated insomnia may interfere with recovery from the primary alcohol addiction and contribute to relapse within the first several months of recovery. 12,15,16 Thus, treating insomnia in recovering alcoholic patients may aid in their recovery and support continued abstinence. Keywords NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptDespite the putative importance of sleep in the recovery process, there is limited information in the addiction literature about appropriate treatment options for insomnia during recovery. This may exist for a variety of reasons: clinicians assume that co-morbid sleep problems will remit with treatment of the primary alcohol condition; sleep problems are de-emphasized as relatively less important in the early stages of treatment for alcohol dependence; or physicians may be reluctant to address sleep problem...

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Antidepressants for insomnia in adults

Everitt

Baldwin

Stuart

et al. 2018

Cochrane Database of Systematic Reviews

110

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We identified relatively few, mostly small studies with short-term follow-up and design limitations. The effects of SSRIs compared with placebo are uncertain with too few studies to draw clear conclusions. There may be a small improvement in sleep quality with short-term use of low-dose doxepin and trazodone compared with placebo. The tolerability and safety of antidepressants for insomnia is uncertain due to limited reporting of adverse events. There was no evidence for amitriptyline (despite common use in clinical practice) or for long-term antidepressant use for insomnia. High-quality trials of antidepressants for insomnia are needed.

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The effects of trazodone on sleep in patients treated with stimulant antidepressants

Cited by 109 publications

References 11 publications

Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study

Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study

Treatment Options for Sleep Disturbances During Alcohol Recovery

Antidepressants for insomnia in adults

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