Numerical calculations were conducted to simulate air and particle behavior near and into the inlet of an aerosol sampler in order to determine sampling efficiency performance. This was done with the pre-verified commercial computational fluid dynamics (CFD) software package, FLUENT (Fluent, Inc., Lebanon, NH, US). Air flow behavior was calculated for steady-state conditions approaching and flowing into 3D geometries of an aerosol sampler free in the air that was similar in dimension to two commercial samplers, namely the Gesamtstaubprobenahme sampler (GSP) and the conical inhalable sampler (CIS). Particle trajectories were calculated in a Lagrangian reference frame on the resulting velocity fields. Based on the particle trajectories, sampling efficiencies were calculated and compared to those reported in the literature for a CIS aerosol sampler. They were found to have similar overall trends for particle sizes up to 21 µm. Using a correction factor, agreement The findings and conclusions in this report are those of the author and do not necessarily represent the views of the Centers for Disease Control and Prevention or the National Institute for Occupational Safety and Health. Mention of a commercial product or trade name does not constitute endorsement by the Centers for Disease Control and Prevention or the National Institute for Occupational Safety and Health.Address correspondence to Aaron J. Bird, M/S 3030, Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. E-mail: ABird@cdc.gov was observed to be very good for smaller particles, but less so for larger particles.