The Effects of Urinary Function and Erectile Function on the Use of Mecobalamin After Nerve Sparing Radical Prostatectomy

Matsushita, Mabumi; Nakagawa, Haruo; Namiki, Shunichi; Ikeda, Yoshihiro; Kaiho, Yasuhiro; Kawamorita, Naoki; Ito, Akihiro; Ishidoya, Shigeto; Saitoh, Sei–Ichi; Arai, Yoichi

doi:10.5980/jpnjurol.100.7

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Matsushita et al [15] reported that mecobalamin, a coenzyme of vitamin B12, promotes the metabolism of nucleic acids, proteins, and lipids via a methyl conversion reaction. Mecobalamin readily enters nerve tissues and promotes the restoration of injured nervous tissue.…”

Section: Mecobalaminmentioning

confidence: 99%

Review of clinical nerve repair strategies for neurorestoration of central nervous system tumor damage

Wang¹,

Sun²,

Meng³

et al. 2020

Journal of Neurorestoratology

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Central nervous system (CNS) tumors are common. In recent years, with the continuous development and popularization of neurosurgery and the advancement of diagnostic and therapeutic instruments, the diagnosis and treatment of diseases have made great progress, but the prognosis of patients depends on multiple clinical factors. In this study, we selected various literatures in the PubMed and Google Scholar search engines using the keywords "nerve repair strategies" , "central nervous system tumor" as well as searched scientifically reviewed historical perspectives and recent advancements and achievements in Neurorestoratology of the CNS. Therefore, this study focuses on the Neurorestoratology of the CNS and its prospects, aiming to provide scientific guidance for the clinical diagnosis and treatment of CNS tumors in the future, and improve the prognosis and quality of life of patients.

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Section: Mecobalaminmentioning

confidence: 99%

Review of clinical nerve repair strategies for neurorestoration of central nervous system tumor damage

Wang¹,

Sun²,

Meng³

et al. 2020

Journal of Neurorestoratology

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“…A study by a Japanese group in patients taking mecobalamin (vitamin B12) during and after RP demonstrated no significant effect of mecobalamin on the recovery of urinary or sexual function. However, an early non-significant recovery effect on urinary function was suggested (103).…”

Section: Vitaminsmentioning

confidence: 99%

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

et al. 2015

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SummaryAimTo develop a non‐invasive management strategy for men with lower urinary tract symptoms (LUTS) after treatment for pelvic cancer, that is suitable for use in a primary healthcare context.MethodsPubMed literature searches of LUTS management in this patient group were carried out, together with obtaining a consensus of management strategies from a panel of authors for the management of LUTS from across the UK.ResultsData from 41 articles were investigated and collated. Clinical experience was sought from authors where there was no clinical evidence. The findings discussed in this paper confirm that LUTS after the cancer treatment can significantly impair men's quality of life. While many men recover from LUTS spontaneously over time, a significant proportion require long‐term management. Despite the prevalence of LUTS, there is a lack of consensus on best management. This article offers a comprehensive treatment algorithm to manage patients with LUTS following pelvic cancer treatment.ConclusionBased on published research literature and clinical experience, recommendations are proposed for the standardisation of management strategies employed for men with LUTS after the pelvic cancer treatment. In addition to implementing the algorithm, understanding the rationale for the type and timing of LUTS management strategies is crucial for clinicians and patients.

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Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice

et al. 2014

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Mecobalamin, a form of vitamin B12 containing a central metal element (cobalt), is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve crush injury in mice, followed by daily intraperitoneal administration of mecobalamin (65 μg/kg or 130 μg/kg) or saline (negative control). Walking track analysis, histomorphological examination, and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve, thickened the myelin sheath in myelinated nerve fibers, and increased the cross-sectional area of target muscle cells. Furthermore, mecobalamin upregulated mRNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury, and of neurotrophic factors (nerve growth factor, brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia. Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes.

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The Effects of Urinary Function and Erectile Function on the Use of Mecobalamin After Nerve Sparing Radical Prostatectomy

Cited by 3 publications

References 8 publications

Review of clinical nerve repair strategies for neurorestoration of central nervous system tumor damage

Review of clinical nerve repair strategies for neurorestoration of central nervous system tumor damage

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice

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