The Effects of Useful Field of View Training on Brain Activity and Connectivity

Ross, Lesley A.; Webb, Christina E.; Whitaker, Christine; Hicks, Jarrod M; Schmidt, Erica L.; Samimy, Shaadee; Dennis, Nancy A.; Visscher, Kristina

doi:10.1093/geronb/gby041

Cited by 28 publications

(26 citation statements)

References 46 publications

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“…While prior functional studies of the UFOV/Double Decision paradigm found bilateral activation associated with performance, our findings demonstrate right lateralization of structures associated with performance (Ross et al, 2018). This pattern of findings is consistent with other cognitive domains within the context of aging.…”

Section: Right Lateralization Of Findingssupporting

confidence: 84%

“…Indeed, the role of regions within the CON network in the present study is supported by work from Ross et al, who assessed functional connectivity between numerous ROIs following a UFOV cognitive training intervention (Ross et al, 2018). Of these ROIs, the orbitofrontal cortex and AI demonstrated strengthened functional connectivity and demonstrated increased BOLD activation with better UFOV performance (Ross et al, 2018). Additionally, cortical thickness declines in these regions were significantly associated with poorer Double Decision performance in the present study.…”

Section: Comparison To Prior Findings In the Ufov/double Decision Tasksupporting

confidence: 78%

“…Persistent CON activation is also associated with attention, error processing, and rule maintenance, all of which are implicated in the Double Decision task (Dosenbach et al, 2007). Indeed, the role of regions within the CON network in the present study is supported by work from Ross et al, who assessed functional connectivity between numerous ROIs following a UFOV cognitive training intervention (Ross et al, 2018). Of these ROIs, the orbitofrontal cortex and AI demonstrated strengthened functional connectivity and demonstrated increased BOLD activation with better UFOV performance (Ross et al, 2018).…”

Section: Comparison To Prior Findings In the Ufov/double Decision Tasksupporting

confidence: 72%

“…In a prior study, eight ROIs were implicated in a task-based UFOV fMRI task: anterior cingulate cortex, anterior insula, DLPFC, inferior parietal lobule, supplementary motor area (SMA), and thalamus. Specifically, these regions were activated when performing the UFOV task, and activation in these ROIs were reduced following a UFOV intervention (Ross et al, 2018). Notably, we found significant cortical thickness declines in a number of these regions associated with poorer Double Decision performance, including the anterior insula (AI), inferior parietal lobule, temporoparietal junction (within the IPL) and visual cortex.…”

Section: Comparison To Prior Findings In the Ufov/double Decision Taskmentioning

confidence: 77%

“…Although speed of processing training using UFOV/Double Decision is one of the more effective forms of cognitive training to date, very few studies have investigated the neural correlates of the UFOV/Double Decision task itself. Two functional magnetic resonance imaging (fMRI) studies utilizing the UFOV task in-scanner have shown significant blood-oxygen level dependent (BOLD) activation of numerous areas, including the anterior cingulate cortex, supplementary motor area, dorsolateral prefrontal cortex (DLPFC), insula, precuneus, temporoparietal junction, and visual cortices (Scalf et al, 2007;Ross et al, 2018).…”

Section: Neural Correlates Of Ufov/double Decision Performance and Spmentioning

confidence: 99%

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Structural Neural Correlates of Double Decision Performance in Older Adults

Kraft

O’Shea

Albizu

et al. 2020

Front. Aging Neurosci.

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Speed of processing is a cognitive domain that encompasses the speed at which an individual can perceive a given stimulus, interpret the information, and produce a correct response. Speed of processing has been shown to decline more rapidly than other cognitive domains in an aging population, suggesting that this domain is particularly vulnerable to cognitive aging (Chee et al., 2009). However, given the heterogeneity of neuropsychological measures used to assess the domains underpinning speed of processing, a diffuse pattern of brain regions has been implicated. The current study aims to investigate the structural neural correlates of speed of processing by assessing cortical volume and speed of processing scores on the POSIT Double Decision task within a healthy older adult population (N = 186; mean age = 71.70 ± 5.32 years). T1-weighted structural images were collected via a 3T Siemens scanner. The current study shows that less cortical thickness in right temporal, posterior frontal, parietal and occipital lobe structures were significantly associated with poorer Double Decision scores. Notably, these include the lateral orbitofrontal gyrus, precentral gyrus, superior, transverse, and inferior temporal gyrus, temporal pole, insula, parahippocampal gyrus, fusiform gyrus, lingual gyrus, superior and inferior parietal gyrus and lateral occipital gyrus. Such findings suggest that speed of processing performance is associated with a wide array of cortical regions that provide unique contributions to performance on the Double Decision task.

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Section: Right Lateralization Of Findingssupporting

confidence: 84%

Section: Comparison To Prior Findings In the Ufov/double Decision Tasksupporting

confidence: 78%

Section: Comparison To Prior Findings In the Ufov/double Decision Tasksupporting

confidence: 72%

Section: Comparison To Prior Findings In the Ufov/double Decision Taskmentioning

confidence: 77%

Section: Neural Correlates Of Ufov/double Decision Performance and Spmentioning

confidence: 99%

See 3 more Smart Citations

Structural Neural Correlates of Double Decision Performance in Older Adults

Kraft

O’Shea

Albizu

et al. 2020

Front. Aging Neurosci.

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The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review

et al. 2020

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Cognitive training (CT) is an increasingly popular, non-pharmacological intervention for improving cognitive functioning in neurodegenerative diseases and healthy aging. Although meta-analyses support the efficacy of CT in improving cognitive functioning, the neural mechanisms underlying the effects of CT are still unclear. We performed a systematic review of literature in the PubMed, Embase and PsycINFO databases on controlled CT trials (N > 20) in aging and neurodegenerative diseases with pre-and post-training functional MRI outcomes up to November 23rd 2018 (PROSPERO registration number CRD42019103662). Twenty articles were eligible for our systematic review. We distinguished between multi-domain and single-domain CT. CT induced both increases and decreases in task-related functional activation, possibly indicative of an inverted U-shaped curve association between regional brain activity and task performance. Functional connectivity within 'cognitive' brain networks was consistently reported to increase after CT while a minority of studies additionally reported increased segregation of frontoparietal and default mode brain networks. Although we acknowledge the large heterogeneity in type of CT, imaging methodology, in-scanner task paradigm and analysis methods between studies, we propose a working model of the effects of CT on brain activity and connectivity in the context of current knowledge on compensatory mechanisms that are associated with aging and neurodegenerative diseases.

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