The Effects of Using Bioglue in Nasal Septal Surgery

Abstract

Objectives: Nasal septal surgery is one of the most common surgical procedure performed by otolaryngologists. Nasal packs are used for bleeding control, prevention of septal hematoma, replacement of mucoperichondrial flaps, and stabilization of the septum after nasal septal surgery. The aim of this study was to investigate the effects of albumin-glutaraldehyde–based tissue adhesive (Bioglue), which can be used as an alternative to nasal pack on the nasal septum after experimental nasal septum surgery. Methods: A total of 16 female Wistar albino rats were randomly separated into the study group (n = 10) and the control group (n = 6). After raising the mucoperichondrial flap on one side of the septum, Bioglue was used to fix the mucoperichondrial flap over the septal cartilage ın the study group and nasal packs (Merocel) were used for fixation in the control group. The rats were sacrificed at 2 and 4 weeks after septoplasty. All the tissue samples were evaluated under light microscope by the same pathologist in respect of foreign-body reaction, degree of inflammation, granulation tissue, fibrosis, cartilage damage, and cilia and goblet cell damage. In the control group, the Merocel packs were removed after 2 days and the groups were compared in terms of hematoma. Results: No hematoma was observed in any group. Septal perforation was determined in all the study group participants and loss of cilia and goblet cells and foreign-body reaction were found in 8 samples of the study group participants and in none of the control group. Conclusions: The results of this study show that Bioglue caused segmental cartilage injury; therefore, it may not suitable for use following septal surgery.

Delayed Wound Healing Resulting from Inflammatory Process in Craniectomy Patients Treated with BioGlue: A Case Series with Literature Review

“…Their research indicated that a surgical procedure on the nasal septum resulted in segmental cartilage injury from BioGlue. 9 Singh et al reported wound complications following BioGlue application and recommended primary drainage, debridement, and removal of all BioGlue residues. 10 Singh and Wales cautioned against the use of BioGlue for hemostasis due to its adhesive and sealing properties.…”

Progress of tissue adhesives based on proteins and synthetic polymers

“…Albumin-based TAs are used to seal pulmonary air leaks [ 87 ] and to perform nephron-sparing [ 88 ], cardiac [ 89 ], nasal septal [ 90 ], proximal aortic [ 81 ], splenic [ 91 ], and inguinal hernia surgeries [ 92 ]. However, these TAs cannot control active bleeding; therefore, they can be used to adhere only to a bloodless area.…”