The Effects of Vaccination in Pregnancy on the Foetus*

Liebeschuetz, H. J.

doi:10.1111/j.1471-0528.1964.tb04256.x

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…Similarly, no evidence of increased risk of adverse pregnancy outcomes was found by Liebeschuetz (1964) in another retrospective cohort that included 157 vaccinated and 1657 unvaccinated or unsuccessfully vaccinated (no reaction at injection site) women attending a maternity hospital during a 6-month period after a mass vaccination campaign in London [30]. The majority of exposed women received the vaccine in the first trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 96%

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Safety of Administering Live Vaccines during Pregnancy: A Systematic Review and Meta-Analysis of Pregnancy Outcomes

et al. 2020

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Live-attenuated vaccines (LAV) are currently contraindicated during pregnancy, given uncertain safety records for the mother–infant pair. LAV might, however, play an important role to protect them against serious emerging diseases, such as Ebola and Lassa fever. For this systematic review we searched relevant databases to identify studies published up to November 2019. Controlled observational studies reporting pregnancy outcomes after maternal immunization with LAV were included. The ROBINS-I tool was used to assess risk of bias. Pooled odds ratios (OR) were obtained under a random-effects model. Of 2831 studies identified, fifteen fulfilled inclusion criteria. Smallpox, rubella, poliovirus, yellow fever and dengue vaccines were assessed in these studies. No association was found between vaccination and miscarriage (OR 0.98, 95% CI 0.87–1.10), stillbirth (OR 1.04, 95% CI 0.74–1.48), malformations (OR 1.09, 95% CI 0.98–1.21), prematurity (OR 0.99, 95% CI 0.90–1.08) or neonatal death (OR 1.06, 95% CI 0.68–1.65) overall. However, increased odds of malformations (OR 1.24; 95% CI 1.03–1.49) and miscarriage after first trimester immunization (OR 4.82; 95% CI 2.38–9.77) was found for smallpox vaccine. Thus, we did not find evidence of harm related to LAV other than smallpox with regards to pregnancy outcomes, but quality of evidence was very low. Overall risks appear to be small and have to be balanced against potential benefits for the mother-infant pair.

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Section: Discussionmentioning

confidence: 96%

“…Four out of nine studies were considered at critical risk of selection bias for the outcome of spontaneous abortion [24,25,30,31], because participants were selected among women attending participating hospitals or clinics, thus missing those receiving care in different facilities and miscarriages occurring before onset of prenatal care.…”

Section: Discussionmentioning

confidence: 99%