The effects of valproic acid and levetiracetam on chicken embryos

Türeci, Ercan; Asan, Ziya; Eser, Mediha; Tanrıverdi, Taner; Alkan, Faruk; Erdinçler, Pamir

doi:10.1016/j.jocn.2010.11.005

Cited by 16 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unique result showing LEV and severe developmental abnormalities was reported by Türeci et al [28] on chicken embryos. They used low and high dose The intensity of immunostaining is grouped into categories: − no staining, + weak staining, ++ moderate staining, +++ strong staining Fig.…”

Section: Discussionmentioning

confidence: 54%

Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 54%

Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The old generation medications used today as the first line treatments still make up the primary step of anti-epileptic treatment despite their known toxic and teratogenic effects [1,4,7,8]. There has been an increasing tendency to prefer new generation anti-epileptic medications over this group of medications referred to as the old generation anti-epileptics [8].…”

Section: Discussionmentioning

confidence: 99%

“…There has been an increasing tendency to prefer new generation anti-epileptic medications over this group of medications referred to as the old generation anti-epileptics [8]. Numerous retrospective and prospective clinical studies have tried to reveal the mechanisms underlying the toxic and teratogenic effects of older generation anti-epileptics and the rates at which these effects are manifested [7]. Information regarding the levels and rates of similar effects associated with new generation anti-epileptics are scarce in the literature.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of levetiracetam and valproic acid on neural tube defect formation in the chick embryo: an experimental study

Asan¹

2019

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: The aim of this study is to compare the dosage-related effects of levetiracetam and valproic acid on neural tube defect formation in chick embryos, when applied as monotherapy and in combination. Material and Method: A total of 360 fertilized pathogens-free white-Leghorn eggs were used in the study. The eggs were allowed to incubate for 72 hours. Total of six groups were formed where each medication was administered in low (250 mcg) and high (500 mcg) doses and in combination. Results obtained from the control and sham groups were compared. Results: The prevalence of NTD was found to be significantly lower in the group that received levetiracetam compared to the group that was treated with valproic acid. It was determined that NTD prevalence increased with a dosage increase in both groups. The prevalence of NTD was found to be significantly higher in groups where the two medications were administered in combination compared to the groups that received a single medication. Discussion: Both levetiracetam and valproic acid have the potential to create NTD. Valproic acid has a higher potential of creating NTD compared to levetiracetam. The likeliness of causing NTD significantly increases depending on dosage for both medications. Both medications have the potential to create NTD during pregnancy and must be used with caution.

show abstract

“…There have been studies on early chicken embryo models, such as the effects of magnetic resonance imaging and cell phone use during pregnancy (9,21); however, too many studies have been performed with drugs. The drugs studied are antiepilectics, such as valproic acid, levetiracetam, lacosamide; analgesics, such as meloxicam, flurbiprofen, metamizole; folic acid antagonists, such as methotrexate; and myeline protector proteins such as glatiramer (3,6,7,13,15,16,18,20,22). One of the most common features of these studies is that they were conducted on early chicken embryo models.…”

Section: █ Discussionmentioning

confidence: 99%

The effect of phenyramidol on neural development in early chicken embryo model

Özgüral

Bahadir²,

Doğan³

et al. 2019

Turkish Neurosurgery

View full text Add to dashboard Cite

AIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model. MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into four groups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggs were opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically. RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (low dosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (high dosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped. CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure in early chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model.

show abstract

The effects of valproic acid and levetiracetam on chicken embryos

Cited by 16 publications

References 31 publications

Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo

Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo

Comparison of the effects of levetiracetam and valproic acid on neural tube defect formation in the chick embryo: an experimental study

The effect of phenyramidol on neural development in early chicken embryo model

Contact Info

Product

Resources

About