The effects of ventricular asynchrony on myocardial perfusion

Localization of Ventricular Tachycardia Exit Site and Subsequent Contraction Sequence and Functional Effects With Bedside Radionuclide Angiography

“…This study demonstrates that ERNA can be used to analyze both the mechanical and "electrical" effects of VT. Such an analysis presents important parallels for the evaluation of the effects of cardiac resynchronization therapy (14,15,18,19) in which accurate, reproducible quantitation of ventricular function, conduction sequence, and synchrony are important. The SDØ and other new parameters have been developed to measure ventricular synchrony based on phase image data (20,21).…”

“…However, ischemia was not evident before VT, rhythm tolerance was unrelated to coronary disease or age, no patient had overt ischemia during electrophysiologic study, and ischemia occurs uncommonly with induced VT (17). Both exit site and dyssynchrony alter regional perfusion (5,19). Yet, even with ischemia, the functional and electrophysiologic effects of VT intolerance remain valid.…”

Clinical management of dilated cardiomyopathy: current knowledge and future perspectives

“…[13] In addition, microvascular damage, intrinsic abnormalities in myocardial blood flow, LBBB and RV pacing responsible for mechanical dyssynchrony and deterioration of coronary flow dynamics contribute to adverse remodeling. [14] Although for years this process appeared to be unfavorable and irreversible, in the last decade, several studies have identified how this process can be stopped and potentially reversed. In patients affected by iDCM, early treatment can be incredibly beneficial in order to reverse this vicious process of cardiac remodeling.…”

The Role of Biventricular Pacing in the Prevention and Therapy of Pacemaker‐Induced Cardiomyopathy

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14]16 We felt that addressing these alterations were beyond the scope of this clinical review.…”

“…Frequent RV pacing alters geometry and function of the LV on multiple levels resulting in a variety of manifestations. [1][2][3][4][5][6][7][8][9][10][11][12] Long-term mandatory (100%) RV pacing, increases LV dimensions (end diastolic and end systolic), LV mass, and left atrial diameter. It also decreases LV ejection fraction (LVEF), and worsens mitral regurgitation.…”