The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial

Salekzamani, Shabnam; Bavil, Abolhassan Shakeri; Mehralizadeh, Hossein; Jafarabadi, Mohammad Asghari; Ghezel, Aymaral; Gargari, Bahram Pourghassem

doi:10.1007/s12020-017-1317-2

Cited by 35 publications

(27 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Main summary of the characteristics of the included studies are described in ▶ Tables 1-3. A total of 22 studies published from 2006 to 2017 covering a total of 7332 human participants, from studies in different countries (Korea [15], Italy [16][17][18][19][20], Sweden [21], China [22][23][24][25][26][27], USA [28,29], Egypt [30], Scandinavian [31], Turkey [1], Iran [7,32], Bulgaria [33], and UK [34]) with age ranging from 18 to 75 years, were identified in this meta-analysis. Most of the participants were women.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most of the participants were women. Of the 22 publications, 19 were population-based observational studies including 4 prospective studies [18,31,33,34], 8 cross-sectional studies [15-17, 19, 23, 24, 26, 27] and 7 case control studies [20-22, 25, 28-30] and 3 studies were randomized placebo-controlled trials (RCTs) [1,7,32]. Overall, three randomized clinical trials comprising 99 patients including premenopausal women [1], overweight type 2 diabetic patients with CHD [7], and metabolic syndrome [32] Also, all of the trials studies were considered to be of higher quality.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Among 3 studies [1,7,32], 2 studies were randomized double-blind clinical trials [7,32] and in the other study, the method of random-ization was not clearly mentioned [1]. Pooled estimate of their results indicated that those who received vitamin D had significantly lower CIMT compared to control group (MD: -0.034, 95 % CI: -0.62 to -0.05, p = 0.012).…”

Section: Association Between Serum Vitamin D Level and Cimt [Observatmentioning

confidence: 99%

See 2 more Smart Citations

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

et al. 2020

View full text Add to dashboard Cite

It is reported that vitamin D deficiency is associated with carotid intima-media thickness (CIMT). In addition, several randomized clinical trials (RCTs) have studied the influence of vitamin D supplement on CIMT. However, results are inconclusive. This review aimed to systematically explore the potential link of the serum vitamin D level with CIMT pooling together observational studies and RCTs. PubMed and Scopus were searched for studies published until February 13, 2018. The Fisher’s z (SE) correlation coefficient, odds ratio (OR), and mean (SD) of changes in CIMT from baseline were used to perform meta-analysis in observational studies and RCTs, respectively. To pool data, both a fixed-effects model and a random-effects model (in case of heterogeneity) were used. Heterogeneity was assessed using Cochran’s Q and I2 tests. Nineteen observational studies and 3 RCTs met inclusion criteria. The pooled correlation coefficients of 17 observational studies showed [(Fisher’s z=− 0.41, 95% CI: –0.63 to –0.19, p<0.001), I2=96.9%, p < 0.001] a significant inverse association between serum vitamin D and risk of CIMT. Pooling three risk estimates of three studies [(OR = 1.69, 95% CI: 0.74 to 3.86, p=0.209); I2=085.1%, p<0.001)] indicated no significant association between serum vitamin D status and risk of CIMT. Combining data of RCTs showed vitamin D supplementation significantly reduced CIMT [(MD: –0.034, 95% CI: –0.62 to –0.05, p=0.012), I2=16.6%, p = 0.301]. Our findings show that serum vitamin D is inversely associated with CIMT and vitamin D supplementation may reduce CMIT.

show abstract

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Association Between Serum Vitamin D Level and Cimt [Observatmentioning

confidence: 99%

See 1 more Smart Citation

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In another study, the consumption of flaxseed oil for 90 d reduced CIMT in obese and overweight non-diabetic elderly patients (34) . However, vitamin D supplementation for 16 weeks did not change CIMT in patients with metabolic syndrome (35) . CIMT is a prognostic predictor of future cardiovascular events.…”

Section: Effects On Carotid Intima-media Thicknessmentioning

confidence: 78%

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

et al. 2019

View full text Add to dashboard Cite

This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·03), insulin (β −1·66 μIU/ml; 95 % CI −2·43, −0·89; P < 0·001), insulin resistance (β −0·49; 95 % CI −0·72, −0·25; P < 0·001) and LDL-cholesterol (β −0·21 mmol/l; 95 % CI −0·41, −0·01; P = 0·04), and a significant increase in insulin sensitivity (β +0·008; 95 % CI 0·004, 0·01; P = 0·001) and HDL-cholesterol (β +0·09 mmol/l; 95 % CI 0·01, 0·17; P = 0·02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (β −1·56 mg/l; 95 % CI −2·65, −0·48; P = 0·005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids’ co-supplementation had beneficial effects on markers of cardiometabolic risk.

show abstract

“…Since vitamin D de ciency has also been linked to adverse cardiovascular outcomes and cancer (14,31), several clinical trials with supplementation have been conducted to determine if improvement in cancer and cardiovascular outcomes occurred. Most trials have shown null results; one evaluated vitamin D supplementation and IMT (32) and a large randomized double-blind trial showed no improvement in cardiovascular outcomes or cancer after supplementation with high doses of vitamin D (2000 UI) (33). These results suggest that vitamin D might be related to cardiovascular health but not through a causal relationship.…”

Section: Discussionmentioning

confidence: 99%

Sun exposure and intima-media thickness in the Mexican Teachers' Cohort

Aguilar

Muñoz-Aguirre²,

Cortés-Valencia

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Previous studies have evaluated how sun exposure affects cardiovascular health. In this sense, some evidence from ecological studies have found an inverse relationship between sun exposure and blood pressure or CVD. The aim of this study is to determine whether long-term sun exposure has a protective role in subclinical cardiovascular disease in adult Mexican women. Methods We conducted a cross-sectional analysis of a sample of women from the Mexican Teachers’ Cohort (MTC) study. Sun exposure was assessed in the MTC 2008 baseline questionnaire, in which women were asked about their sun-related behavior. Vascular neurologists measured carotid intima-media thickness (IMT) using standard techniques. Multivariate linear regression models were used to estimate the percentage difference in mean IMT and 95% confidence intervals (95% CIs), according to categories of sun exposure and multivariate logistic regression models were used to estimate the odds ratio (OR) and 95% CIs for carotid atherosclerosis. Results The mean age of participants was 49.6 ± 5.5 years, the mean IMT was 0.678 ± 0.097 mm, and the mean accumulated hours of weekly sun exposure were 2.9 ± 1.9. Prevalence of carotid atherosclerosis was 20.9%. Compared to women in the lowest category of sun exposure, the multivariate adjusted ORs of carotid atherosclerosis were 0.54 (95%CI: 0.24, 1.18) for women who were exposed 9 hours. For women who denied regular sun screen use, those in the higher exposure category (9 hours) had lower mean IMT compared to those in the lower category (multivariable-adjusted mean % difference = -2.67; 95%CI: -6.9, -1.5). Conclusion In general, we observed that cumulative sun exposure was inversely associated with IMT and subclinical carotid atherosclerosis. Our findings suggest that public health messages should also consider the sun’s positive role for health, while still emphasizing the negative impacts of excessive exposure.

show abstract

The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial

Abstract: Vitamin D supplementation improved some proatherogenic inflammatory markers in subjects with metabolic syndrome. No changes of high sensitivity C-reactive protein and carotid intima media thickness were shown after 16 weeks.

Cited by 35 publications

References 50 publications

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

Sun exposure and intima-media thickness in the Mexican Teachers' Cohort

Contact Info

Product

Resources

About