The effects of vitamin D<sub>3</sub>supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study

Close, Graeme L.; Leckey, Jill J.; Patterson, Marcelle; Bradley, Warren J.; Owens, Daniel J.; Fraser, William D.; Morton, James P.

doi:10.1136/bjsports-2012-091735

Cited by 135 publications

(183 citation statements)

References 58 publications

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“…However, in contrast to our study, the effect of different supplementation doses was investigated in subjects with 25(OH)D levels O50 nmol/l and in groups with equal baseline 25(OH)D levels. Our observation, that lower baseline 25(OH)D concentrations resulted in a greater magnitude of response, was also previously reported (7,20,21,22 (20,21). The policy in our study resulted in mean achieved 25(OH)D values that were comparable after 4 and 11 months for all doses.…”

Section: Discussionsupporting

confidence: 77%

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Shab-Bidar

Bours

Geusens

et al. 2013

European Journal of Endocrinology

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Objective: Guidelines on the need for dose adaptation of vitamin D3 supplementation according to baseline serum 25(OH)D are inconclusive. The effects of increasing doses of vitamin D3 at lower baseline serum 25(OH)D values on the serum 25(OH)D after 4.2 and 11 months were determined in an observational study. Design: A prospective observational study. Methods: Out of 1481 consecutive women and men with a recent clinical fracture, 707 had a baseline 25(OH)D level !50 nmol/l and were supplemented with increasing doses of vitamin D3 (400, 800, 1700, and R3500 IU/day) according to the lower baseline 25(OH)D. Final analysis was restricted to the 221 participants who had full follow-up data available for 11 months. Results: Serum 25(OH)D R50 nmol/l was achieved in 57-76% of patients after 4.2 months and in 73-79% after 11 months. These percentages were similar for all doses (PZ0.06 and PZ0.91 respectively). The mean achieved 25(OH)D was similar for all dose groups (56.1-64.0 nmol/l after 4.2 months and 60.2-76.3 nmol/l after 11 months). With multivariate analysis, the increase in 25(OH)D (17G32.0 after 4.2 months and 24.3G34.0 nmol/l after 11 months) was dependent on the baseline 25(OH)D (P!0.001), not on supplementation dose, season, age, BMI, or gender. Conclusions: The increase in serum 25(OH)D was significantly larger with higher vitamin D3 supplementation doses. However, this dose-effect response was mainly explained by the baseline 25(OH)D, not the supplementation dose, with a greater magnitude of response at lower baseline 25(OH)D concentrations. In 21-27% of patients, serum 25(OH)D3 levels did not reach 50 nmol/l after 11 months, at any dose. Further studies are needed to identify possible causes of suboptimal response such as non-compliance, undiagnosed malabsorption syndromes, or variability in cholecalciferol content of the vitamin D supplements.

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Section: Discussionsupporting

confidence: 77%

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Shab-Bidar

Bours

Geusens

et al. 2013

European Journal of Endocrinology

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“…9 Daily supplements of 800-1000 IU cholecalciferol have been shown to raise serum levels by 24-29 nmol/L, reaching a steady-state after a minimum of three months, but most likely after six months. 18 Retesting after nine months also showed comparatively little change in median vitamin D levels, which may suggest inadequate ongoing maintenance or poor compliance.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D assessment in primary care: changing patterns of testing

Zhao

Gardner

Taylor³

et al. 2015

London Journal of Primary Care

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. The number of vitamin D tests requested by primary care, and the associated cost, is rapidly increasing. . More cases of vitamin D deficiency were detected each year, but the odds of detecting deficiency decreased. . Repeat tests form a significant proportion of total requests, and should be performed after three to six months. . Seasonal variation in vitamin D levels should always be considered when requesting tests and interpreting results. Clinicians should consider risk factors for vitamin D deficiency to ensure targeted testing of patients. Why this matters to usThere is increasing awareness of the importance of vitamin D for maintaining musculoskeletal health by both the medical profession and the public. The number of requests for vitamin D testing from primary care is consequently increasing. Testing is expensive and can amount to a substantial financial burden, particularly if testing and retesting are performed inappropriately. There is a need to develop clear guidance for assessing vitamin D status in primary care. We believe our observations and recommendations will inform to improve the cost-effectiveness of vitamin D testing, its ability to influence management and thus make a real impact within primary care practice and patient care. Although this study was carried out in Liverpool, conclusions remain relevant to London given its greater black, Asian and minority ethnic population who are at increased risk of vitamin D deficiency.

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“…Participants were randomized into those receiving placebo or vitamin D. No improvement of exercise performance was observed, most probably because none of the athletes had low vitamin D levels prior to treatment. 130 The lack of any beneficial effect of vitamin D supplementation on athletes with adequate levels of vitamin D prior to treatment was also documented in reports involving rowers and football players.…”

Section: Effect Of Vitamin D Supplementation On Athletic Performancementioning

confidence: 99%

“…Thus, Close et al 130 examined the effects of vitamin D supplementation on several exercise performance indices in club-level athletes. Participants were randomized into those receiving placebo or vitamin D. No improvement of exercise performance was observed, most probably because none of the athletes had low vitamin D levels prior to treatment.…”

Section: Effect Of Vitamin D Supplementation On Athletic Performancementioning

confidence: 99%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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The effects of vitamin D₃supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study

Abstract: Both 20 000 and 40 000 IU vitamin D3 supplementation over a 6-week period elevates serum 25[OH]D concentrations above 50 nmol/l, but neither dose given for 12 weeks improved our chosen measures of physical performance.

Cited by 135 publications

References 58 publications

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Vitamin D assessment in primary care: changing patterns of testing

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

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The effects of vitamin D3supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study

Abstract: Both 20 000 and 40 000 IU vitamin D3 supplementation over a 6-week period elevates serum 25[OH]D concentrations above 50 nmol/l, but neither dose given for 12 weeks improved our chosen measures of physical performance.

Cited by 135 publications

References 58 publications

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Vitamin D assessment in primary care: changing patterns of testing

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

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Product

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About

The effects of vitamin D₃supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study