The Effects of Vitamin D Supplementation in Patients with Knee Osteoarthritis: Uncontrolled Open Label Clinical Trial

Alsubiaee, Khaled M; Alkhathlan, Khalid T; Omair, Amir; Alenezi, Farhan M

doi:10.4172/2167-7921.1000222

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…According to their results, the posttreatment WOMAC scores did not change significantly, despite the significant improvement of vitamin D levels. 32 The same results were observed in the study of Arden et al 33 as well as in the systematic review and meta-analysis of randomized clinical trials performed by Diao et al 34 By contrast, Gao et al, 35 in a meta-analysis of randomized controlled trials, concluded that vitamin D supplementation is effective in improving the WOMAC pain and function in patients with knee OA. In accordance with the study of Gao et al, 35 we did not find an association between serum vitamin D levels and the WOMAC scores of the patients.…”

Section: Discussionsupporting

confidence: 53%

“…Several studies have reported an association between serum vitamin D level and WOMAC scores of patients with knee OA. Alsubiaee et al 32 conducted a clinical trial to evaluate the effect of vitamin D supplementation on WOMAC scores of 58 vitamin D deficient knee OA patients. According to their results, the posttreatment WOMAC scores did not change significantly, despite the significant improvement of vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

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Association of Serum Vitamin D with Serum Cytokine Profile in Patients with Knee Osteoarthritis

et al. 2021

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Objective The role of vitamin D in the pathogenesis of osteoarthritis (OA) is not well understood. In this study, we aimed to investigate the association of serum vitamin D with the serum cytokine profile in patients with primary knee OA. Design In a cross-sectional study, 116 patients with radiologic diagnosis of grade I to III knee OA were included. The study population included 79 (75.9%) females and 25 (24.1%) males with a mean age of 55.1 ± 9.6 years. The serum concentration of IL-6, IL-8, TNF-α, IL-4, IL-10, IL-13, and vitamin D were assessed using an enzyme-linked immunosorbent assay. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used for the assessment of patient’s reported disability associated with knee OA. Results Serum vitamin D status was deficient, insufficient, and sufficient in 18 (15.5%), 63 (54.3%), 35 (30.2%) patients, respectively. Higher levels of serum IL-6 were observed in patients with vitamin D deficiency ( P = 0.022). The mean serum vitamin D level was not associated with OA grade ( P = 0.88) and WOMAC scores of the patients ( P = 0.67). Serum IL-6 level was significantly associated with both OA grade and WOMAC scores of the patients ( P < 0.001 and P = 0.001, respectively). The vitamin D status was not significantly associated with the serum levels of other evaluated cytokines. Conclusion Vitamin D deficiency in knee OA seems to be associated with a higher release of IL-6. Therefore, vitamin D supplementation could reduce the disease burden by controlling the IL-6 release.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Association of Serum Vitamin D with Serum Cytokine Profile in Patients with Knee Osteoarthritis

et al. 2021

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“…37 In details, the findings of several studies indicate a potential preventive role of vitamin D in KOA. [38][39][40] Besides this, the findings from several longitudinal studies 16,41,42 and systematic reviews 43 are promising, which provide encouragement for further studies. However, numerous randomized clinical trials that examined the therapeutic benefits of vitamin D supplementation in treating KOA did not find any conclusive evidence of its effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis

Saengsiwaritt,

Jittikoon,

Chaikledkaew

et al. 2023

Clinical Translational Sci

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Aberrant autophagic activity is observed in osteoarthritic joints. Vitamin D was shown to alleviate not only osteoarthritis severity, but also autophagy process. However, the influence of vitamin D on autophagy in knee osteoarthritis (KOA) remains ambiguous. This study aimed to determine the effect of vitamin D2 on serum levels of autophagosome protein LC3A in patients with KOA and whether LC3A levels were correlated with serum 25‐hydroxyvitamin D (25(OH)D) and clinical outcomes of patients with KOA. A total of 165 patients with KOA and 25 healthy controls were recruited. Vitamin D2 (ergocalciferol) was administered to patients with KOA at a weekly dosage of 40,000 IU. Serum LC3A, knee pain and functional scores, muscle strength, physical performance, and biochemical parameters were examined before and after 6 months of vitamin D2 supplementation. Serum LC3A levels were significantly higher in patients with KOA than healthy controls. In patients with KOA, vitamin D2 supplementation significantly decreased serum LC3A levels. Furthermore, baseline levels of serum LC3A were significantly associated with radiographic severity, pain and functional scores, total cholesterol, hs‐CRP, IL‐6, protein carbonyl, and serum 25(OH)D. After adjusting for established confounders, independent relationships among serum LC3A and radiographic severity, pain and functional scores, total cholesterol, hs‐CRP, IL‐6, protein carbonyl, and serum 25(OH)D were also observed. Vitamin D2 supplementation was shown to not only decrease serum levels of LC3A, inflammatory markers, as well as oxidative stress, but also improve muscle strength and physical performance in patients with KOA.

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“…Vitamin D treatment in patients with knee osteoarthritis improved both knee pain and function [ 10 ] and may have a role in reducing knee and hip pain in the elderly with lower serum vitamin D concentrations (< 25 nmol/L) than at higher levels. On the other hand, there was no benefit of vitamin D supplementation in improving pain, stiffness, physical function and cartilage volume loss reduction [ 9 , 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and its association with symptom severity in knee osteoarthritis: a cross sectional study at a national referral hospital in Uganda

2021

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Background Vitamin D deficiency is highly prevalent among patients with osteoarthritis. It is associated with joint pain, stiffness and worse physical function. Whether vitamin D deficiency is associated with osteoarthritis is controversial. We investigated serum vitamin D levels and its association with symptom severity in patients with knee osteoarthritis. Methods Between January 2020 to March and May 2020, we conducted a cross sectional study at a national referral hospital in Uganda. Using the American College of Rheumatology clinical criteria, 107 consenting adults were diagnosed with knee osteoarthritis. A questionnaire captured patient demographics and clinical characteristics. Joint pain, stiffness and physical function severity were assessed and graded based on the Western Ontario and McMaster Universities Arthritis Index (WOMAC). We determined serum vitamin D levels by electrochemilumniscence immunoassay. The data were analysed and adjusted for age, sex, education, occupation, family history, body mass index (BMI) and calcium supplementation. Results Of the 107 patients, 92 (86%) patients were females, mean (SD) age was 58.1 (12.6) years. Nearly 65% of the patients had suboptimal serum vitamin D levels < 30 ng/ml. The median (Q1, Q3) WOMAC joint scores were as follows: pain 8.0 (5, 11), stiffness 1 (0, 2), physical function 29.0 (16, 41) and total WOMAC 39.0 (21, 54). Spearman correlations between serum vitamin D levels with symptom severity were as follows: joint pain (r = 0.18, p = 0.06), stiffness (r = 0.13, p = 0.17), physical function (r = 0.09, p = 0.36) and total WOMAC (r = 0.13, p = 0.19). Conclusion Serum vitamin D levels are not associated with joint pain, stiffness and physical function severity. Older age and higher BMI are associated with vitamin D deficiency in patients with knee osteoarthritis attending a national referral hospital rheumatology clinic in Uganda. Suboptimal vitamin D is an independent risk factor for total mortality in the general population. Clinical guidelines and further studies to determine age and BMI ranges required for vitamin D screening are needed in patients with osteoarthritis in Uganda. Patients are advised to keep a normal BMI.

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The Effects of Vitamin D Supplementation in Patients with Knee Osteoarthritis: Uncontrolled Open Label Clinical Trial

Abstract: Background: Osteoarthritis (OA) is a degenerative disease that affects joints. The current relationship between low vitamin D levels, functions, and symptoms of osteoarthritis is controversial.

Cited by 6 publications

References 15 publications

Association of Serum Vitamin D with Serum Cytokine Profile in Patients with Knee Osteoarthritis

Association of Serum Vitamin D with Serum Cytokine Profile in Patients with Knee Osteoarthritis

Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis

Vitamin D and its association with symptom severity in knee osteoarthritis: a cross sectional study at a national referral hospital in Uganda

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