The effects of waterborne uranium on the hatching success, development, and survival of early life stages of zebrafish (Danio rerio)

Bourrachot, Stéphanie; Simon, Olivier; Gilbin, Rodolphe

doi:10.1016/j.aquatox.2008.07.013

Cited by 65 publications

(43 citation statements)

References 37 publications

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“…Bourrachot et al (2008) presents data from 0 to 15 d and the authors started feeding early juveniles on day 9; control mortality also increases after 9 d. The increase in control mortality in combination with low control W d indicate that food is hardly eaten and suggests a water quality problem. For this reason we restrict analysis to the first 9 d where no extra organic material (liquid food) was added to the system.…”

Section: Day Embryo and Early Juvenile Experimentsmentioning

confidence: 99%

“…Barillet et al (2005) and Barillet et al (2011) present adult bioaccumulation data (nmol U per g whole body wet mass: M Q w ) at several exposure concentrations (table A.1, Online Appendix A). Bourrachot et al (2008) demonstrate toxicological effects of U on embryo and early juvenile zebrafish growth and survival in combination with bioaccumulation. Bourrachot (2009) further demonstrates a decrease in total egg output (N , # eggs) with increasing U concentrations (84 and 1054 nM) in combination with elimination of U through reproduction.…”

Section: Other Data and Parameter Estimationmentioning

confidence: 99%

“…The contribution of initial amount of reproductive material to total biomass at the onset of adult exposure experiments in combination with negligible growth hampers firm conclusions about effects on growth when analysing adult data sets. However, uranium clearly impacts embryo and early juvenile growth (Bourrachot et al, 2008), fig. 10.…”

Section: Effects On Growthmentioning

confidence: 99%

“…The chorion is assumed to be part of the overheads of growth (quantified by κ R ) and Bourrachot (2009) has demonstrated that a small part of uranium ends up in the chorion in the case of maternal transfer to offspring. We also did not account for adsorption to the chorion during direct exposure to offspring which was also demonstrated to occur (Bourrachot et al, 2008). It is capital to link any toxico-kinetic module with the energetics of the organism (e.g.…”

Section: Deviations From the Extended One Compartment Toxico-kinetic mentioning

confidence: 99%

“…This case is also not addressed in this study. Contributions from accidentsḣ acc are estimated directly from control data (Bourrachot et al, 2008) and contributions from Uḣ Q are taken proportional to [M Q ] such that:…”

Section: One Compartment Toxico-kinetic Modulementioning

confidence: 99%

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Effects of uranium on the metabolism of zebrafish, Danio rerio

et al. 2012

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The increasing demand for nuclear energy results in heightened levels of uranium (U) in aquatic systems which present a potential health hazard to resident organisms. The aim of this study was to mechanistically assess how chronic exposure to environmentally relevant concentrations of U perturbs the complex interplay between feeding, growth, maintenance, maturation and reproduction throughout the life-cycle of an individual. To this end we analysed literature-based and original zebrafish toxicity data within a same mass and energy balancing conceptual framework. U was found to increase somatic maintenance leading to inhibition of spawning as well as increase hazard rate and costs for growth during the early life stages. The fish's initial conditions and elimination through reproduction greatly affected toxico-kinetics and effects. We demonstrate that growth and reproduction should be measured on specific individuals since mean values were hardly interpretable. The mean food level differed between experiments, conditions and individuals. This last 'detail' contributed substantially to the observed variability by its combined effect on metabolism, toxic effects and toxico-kinetics. The significance of this work is that we address exactly how these issues are related and derive conclusions which are independent of experimental protocol and coherent with a very large body of literature on zebrafish eco-physiology.

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Section: Day Embryo and Early Juvenile Experimentsmentioning

confidence: 99%

Section: Other Data and Parameter Estimationmentioning

confidence: 99%

Section: Effects On Growthmentioning

confidence: 99%

Section: Deviations From the Extended One Compartment Toxico-kinetic mentioning

confidence: 99%

Section: One Compartment Toxico-kinetic Modulementioning

confidence: 99%

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Effects of uranium on the metabolism of zebrafish, Danio rerio

et al. 2012

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How Do Actinyls Interact with Hyperphosphorylated Yolk Protein Phosvitin?

Kumar

Creff

Hennig

et al. 2019

Chemistry A European J

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The development of the nuclear industry has raised multiple questions abouti ts impact on the biotope and humans. Proteinsare key biomolecules in cell machinery and essentiali nd eciphering toxicologicalp rocesses. Phosvitin was chosen as ar elevant model for phosphorylated proteins because of its important role as an iron, calcium, and magnesium storagep rotein in egg yolk. Am ultitechnique spectroscopici nvestigation was performed to revealt he coordination geometry of two oxocations of the actinide family (actinyl U VI ,N p V )i ns peciation with phosvitin. IR spectroscopy revealed phosphoryl groups as the main functional groups interacting with U VI .T his was confirmed through laser luminescence spectroscopy (U) and UV/Vis absorption spectroscopy (Np). For U VI ,X -ray absorption spectroscopy at the L III edge revealed as mall contribution of bidentate binding present, alongw ith predominantly monodentate binding of phosphoryl groups;f or Np V ,u niquely bidentate binding was revealed. As ap erspective to this work, X-ray absorptions pectroscopy speciationo fU VI and Np V in the extracted yolk of living eggs of the dogfish Scyliorhinus canicula was determined;t his corroborated the binding of phosphorous togetherw ithareduction of the actinyl moiety.S uch data are essential to pinpoint the mechanisms of heavy metals( actinyls) accumulation and toxicityi no viparous organisms, and therefore, contributet oashift from descriptive approaches to predictive toxicology.

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Exploring ecotoxicological fish bioassay for the evaluation of uranium reprotoxicity

Simon

Floc'h

Geffroy

et al. 2014

Enviro Toxic and Chemistry

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Although reproduction in fish is known to be sensitive to metal exposure, few ecotoxicological studies have focused on the toxicological effects of metals. Because uranium (U) is naturally present in aquatic ecosystems (0.6-2 mg/L), freshwater organisms are subjected to chronic U exposure. Although new standardized assays are currently being developed to mimic realistic exposure conditions, they could be improved by taking into account the contamination that occurs throughout the life cycle of fish. The authors initially evaluated the effect of food (commercial flakes vs pure Spirulina) and ionic composition of the exposure medium on the reproductive performance of Danio rerio. The effects of U exposure on reproduction then were assessed 1) for the F0 adult stage at short exposure times (5 d, 20 d, and 40 d), and 2) for the F0 stage and the F1 generation after 200 d of exposure to control, low (20 µg U/L), and moderate (250 µg U/L) waterborne levels of U. Reproductive endpoints (reproductive success, fecundity, number of spawns, egg and larvae viability, and hatching) were measured mainly after the first spawn and after 10 d of cumulative spawns. The authors evaluated the plasticity of these endpoints and compared the effect of exposure conditions to identify the most relevant markers of the effect of U exposure on reproductive performance of D. rerio.

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The effects of waterborne uranium on the hatching success, development, and survival of early life stages of zebrafish (Danio rerio)

Cited by 65 publications

References 37 publications

Effects of uranium on the metabolism of zebrafish, Danio rerio

Effects of uranium on the metabolism of zebrafish, Danio rerio

How Do Actinyls Interact with Hyperphosphorylated Yolk Protein Phosvitin?

Exploring ecotoxicological fish bioassay for the evaluation of uranium reprotoxicity

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