AimTo systematically review the effectiveness of wheeled mobility interventions in children and young people with cerebral palsy (CP).MethodA systematic literature search was performed in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, EBSCO, PEDro, and Web of Science using database‐specific concepts such as ‘child’ and ‘wheelchair’. Studies focusing on wheeled mobility skill interventions with participants aged 6 to 21 years with CP were included.ResultsTwenty studies with 203 participants were included. The impact of wheeled mobility skill interventions was assessed on mobility skills (n = 18), activity and participation (n = 10), and quality of life (n = 3). No studies reported effects on stress, fatigue, and motivational aspects. Interventions included power wheelchair skill training (n = 12), computer‐based training (n = 5), smart wheelchair training (n = 2), and manual wheelchair training (n = 1), showing positive wheeled mobility intervention effects. Study quality based on the Methodological Index for Non‐Randomized Studies scale was 9 out of 16 and 14 out of 24 for non‐comparative and comparative studies respectively. Risk of bias was serious‐to‐critical on the Risk of Bias in Non‐Randomized Studies of Interventions.InterpretationWheeled mobility interventions showed promising beneficial effects on wheeled mobility, activity and participation, and quality of life for children and young people with CP. Future studies with structured and standardized training programmes and assessment tools are warranted to further accelerate the wheeled mobility skill acquisition process in this population.