The effects of Δ9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study

Ton, J.M. Ng Cheong; Gerhardt, Greg A.; Friedemann, M; Etgen, Anne M.; Rose, Greg; Sharpless, Nansie S.; Gardner, Eliot L.

doi:10.1016/0006-8993(88)90749-4

Cited by 123 publications

(23 citation statements)

References 36 publications

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“…Striatal dopamine hyperactivity has long been implicated in mediating information-processing abnormalities seen in schizophrenia (see Braff and Geyer (1990) for a review) and, recently, implicated in disrupting negative priming (Amitai et al, 2013). As noted above, THC increases levels of dopamine in the rat striatum (Ton et al, 1988) and though administration of THC may not reliably increase striatal dopamine transmission in healthy control participants, it has been shown to do so in patients with psychosis and unaffected first-degree relatives (Kuepper et al, 2013). Adolescents may similarly be more sensitive to the dopaminergic effects of cannabis in the striatum.…”

Section: Discussionmentioning

confidence: 93%

“…Specifically, Bloomfield et al (2014) found that among chronic users of cannabis prone to positive psychosislike effects in response to cannabis, frequency of use correlated significantly with reduced dopamine synthesis capacity in the striatum. THC has been shown to increase striatal dopamine transmission in rats (Ton et al, 1988) and humans (Bossong et al, 2009). However, as Bloomfield et al (2014) suggest, chronic use of cannabis in humans (assuming no other risk factors are present) may lead to a downregulation of dopaminergic activity in the striatum.…”

Section: Discussionmentioning

confidence: 97%

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Cannabis use, schizotypy, and negative priming

Albertella

Pelley

Copeland

2015

Psychiatry Research

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Cannabis use, schizotypy, and negative priming

Albertella

Pelley

Copeland

2015

Psychiatry Research

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“…In vivo microdialysis shows that acute THC increases dopamine efflux in the prefrontal cortex (PFC)41, striatum42 and nucleus accumbens (NAc)43. Only one study did not find THC–induced increases in dopamine efflux44, which may have been related to route of administration since that study used a THC gavage whereas the other studies used intravenous injection which produces a rapid increase in THC which reaches the brain promptly compared to gavage which favours sequestration in lipid compartments due to the very high lipid solubility of THC45.…”

Section: Acute Thc and Presynaptic Dopamine In Animalsmentioning

confidence: 99%

The effects of Δ9-tetrahydrocannabinol on the dopamine system

Bloomfield

Ashok

Volkow

et al. 2016

Nature

294

201

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Preface Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, is a pressing concern to global mental health. Patterns of use are changing drastically due to legalisation, availability of synthetic analogues (‘spice’), cannavaping and aggrandizements in the purported therapeutic effects of cannabis. Many of THC’s reinforcing effects are mediated by the dopamine system. Due to complex cannabinoid-dopamine interactions there is conflicting evidence from human and animal research fields. Acute THC causes increased dopamine release and neuron activity, whilst long-term use is associated with blunting of the dopamine system. Future research must examine the long-term and developmental dopaminergic effects of the drug.

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“…In this context, it might be the case that KOR activity plays a role in the modulation of THC's rewarding effects and thus the reported change in place avoidance induced by the blocking of KOR reflects changes in reward and not in THC's aversive effects. Such a possibility is supported by the fact that THC increases dopamine release at the nucleus accumbens (Jianping et al 1990; Tanda et al 1997; Ton et al 1988) and increases dynorphin production and release (Houser et al 2000; Mason et al 1999; Welch and Eads 1999) which in turn inhibits mesolimbic dopamine (Manzanares et al 1991; Margolis et al 2006; Spanagel et al 1992). Blocking KOR activity would increase DA and THC's rewarding effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of norbinaltorphimine on ∆9-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats

et al. 2015

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Rationale The aversive effects of Δ9-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the aversive effects induced by KOR agonists, a different mechanism might mediate the aversive effects of THC in this age group. Objectives The present study was designed to assess the impact of KOR antagonism on the aversive effects of THC in adolescent and adult rats using the conditioned taste avoidance (CTA) procedure. Methods Following a single pretreatment injection of norbinaltorphimine (norBNI; 15 mg/kg), CTAs induced by THC (0, 0.56, 1.0, 1.8 and 3.2 mg/kg) were assessed in adolescent (n = 84) and adult (n = 83) Sprague Dawley rats. Results The KOR antagonist, norBNI, had weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that norBNI both attenuated and strengthened taste avoidance dependent on dose and trial. norBNI had limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, norBNI had no effect on THC-induced taste avoidance in adult rats as well. Conclusions That norBNI had no significant effect on THC-induced avoidance in adults and a minor and inconsistent effect in adolescents demonstrates that the aversive effects of THC are not mediated by KOR activity as assessed by the CTA design in Sprague Dawley rats.

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The effects of Δ9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study

Cited by 123 publications

References 36 publications

Cannabis use, schizotypy, and negative priming

Cannabis use, schizotypy, and negative priming

The effects of Δ9-tetrahydrocannabinol on the dopamine system

Effect of norbinaltorphimine on ∆9-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats

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