The effects of ω3 and ω6 fatty acid-enriched diets on plasma lipoproteins and apoproteins in familial combined hyperlipidemia

Failor, Richard A; Childs, Marian T.; Bierman, Edwin L.

doi:10.1016/0026-0495(88)90061-3

Cited by 53 publications

(24 citation statements)

References 32 publications

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“…Results in this study demonstrate a striking reduction in total and LDL cholesterol as well as in apo B levels in subjects with FH consuming n-3 and n-6 14 In contrast, while n-6-enriched diets have consistently lowered total 10 -31 and LDL cholesterol along with apo B levels 10 in hyperlipidemic subjects, n-3-enriched diets have not produced uniform effects on LDL cholesterol and apo B in all hyperlipidemic individuals, 5 -13 -14 including paradoxical increases in plasma LDL apo B concentrations in some hyperlipidemic subjects. 13 ' 14 In a previous study from this laboratory, FaUor et al 14 demonstrated increases in plasma LDL apo B levels in three of four men with FCHL consuming a similar salmon oil-rich diet when compared with a butter-based diet.…”

Section: Discussionmentioning

confidence: 54%

“…13 ' 14 In a previous study from this laboratory, FaUor et al 14 demonstrated increases in plasma LDL apo B levels in three of four men with FCHL consuming a similar salmon oil-rich diet when compared with a butter-based diet. 9 Similar elevations in LDL apo B concentrations were noted by Sullivan et al 13 in 23 hypertriglyceridemic subjects treated with 15 g/day of a fish oil concentrate (Max-EPA) for at least 4 weeks.…”

Section: Discussionmentioning

confidence: 93%

“…511 " 14 The major metabolic effects of n-3 fatty acids appear to be reductions in the hepatic synthesis and plasma levels of triglyceride and very low density lipoprotein (VLDL) cholesterol. 12 Smaller decreases in low density lipoprotein (LDL) cholesterol levels have been demonstrated in normal subjects, while variable LDL changes have been noted in hyperlipidemic subjects.…”

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confidence: 99%

“…The results indicate that the LDL cholesterol and apo B responses of FH subjects to n-3 and n-6 fatty acids are comparable to those in normal controls but are in marked contrast to the effects previously observed in subjects with FCHL. 14 …”

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confidence: 99%

“…12 Smaller decreases in low density lipoprotein (LDL) cholesterol levels have been demonstrated in normal subjects, while variable LDL changes have been noted in hyperlipidemic subjects. 5 ' 12 -13 In previous studies, we 14 have shown a paradoxical increase in LDL cholesterol in three of four subjects with familial combined hyperlipidemia (FCHL) consuming an n-3-enriched diet.…”

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Effects of n-3 and n-6 fatty acid-enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia.

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Failor

Childs

et al. 1991

Arterioscler Thromb

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Polyunsaturated fatty acids in vegetable (n-6) and marine (n-3) oils have been shown to reduce cholesterol levels in normolipidemic individuals. However, there is relatively little information available on the lipoprotein responses to dietary n-6 and n-3 fatty acids in individuals with genetic forms of hyperlipidemia at risk for premature cardiovascular disease. We studied five subjects with heterozygous familial hypercholesterolemia (FH), as well as five normal controls, on three rigidly controlled diets differing primarily in their fatty acid composition. FH subjects reduced their total plasma cholesterol by 34% during the n-3 diet and by 26% with the n-6 diet (both p<0.001) when compared with values while on a butter diet In addition, low density lipoprotein (LDL) cholesterol fell 31% and 29% (both/><0.001), and apolipoprotein B (apo B) levels dropped 28% and 27% (both p<0.01) during the n-3 and n-6 diets, respectively. A significant reduction of total and LDL cholesterol as well as of apo B was also noted in normal controls during n-3 and n-6 diets. Total plasma triglyceride and high density lipoprotein cholesterol fell significantly during n-3 diets in normal and FH subjects. Thus, FH and normal subjects respond in a similar fashion to diets low in saturated fatty acids and rich in n-3 and n-6, with decreased LDL cholesterol and apo B concentrations. (Arteriosclerosis and Thrombosis 1991;ll:47-54)

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of n-3 and n-6 fatty acid-enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia.

Friday

Failor

Childs

et al. 1991

Arterioscler Thromb

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Omega 6 fatty acids for the primary prevention of cardiovascular disease

Al-Khudairy

Hartley

Clar³

et al. 2015

Cochrane Database of Systematic Reviews

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We found no studies examining the effects of either increased or decreased omega 6 on our primary outcome CVD clinical endpoints and insufficient evidence to show an effect of increased or decreased omega 6 intake on CVD risk factors such as blood lipids and blood pressure. Very few trials were identified with a relatively small number of participants randomised. There is a need for larger well conducted RCTs assessing cardiovascular events as well as cardiovascular risk factors.

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Stoffwechselwirkungen von ω‐3‐Fettsäuren

Tatò

1993

Fett/Lipid

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Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid o n platelet fatty acids and excretion of thromboxane A2 and PGIz metabolites in healthy young m e n , Metabolism 42,463 [1993]. Derr, f! M . Ktis-Etherton, 7: A. Pearson and E H . Seligson,T h e role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: 11. T h e plasma total and low-density lipoprotein cholesterol response of individual fatty acids, Metabolism 42, 130 [1993].' R. P Mensink and M. B. Katan, Effect of dietary fatty acid on serum lipids and lipoproteins: a meta-analysis of 27 trials, Arterioscl. Thromb. 12, 911 [1992]. I! L. Zock and M . B. Katan, Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans, J. Lipid

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The effects of ω3 and ω6 fatty acid-enriched diets on plasma lipoproteins and apoproteins in familial combined hyperlipidemia

Cited by 53 publications

References 32 publications

Effects of n-3 and n-6 fatty acid-enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia.

Effects of n-3 and n-6 fatty acid-enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia.

Omega 6 fatty acids for the primary prevention of cardiovascular disease

Stoffwechselwirkungen von ω‐3‐Fettsäuren

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