The Effects on Human Sleep and Circadian Rhythms of 17 Days of Continuous Bedrest in the Absence of Daylight

Monk, Timothy H.; Buysse, Daniel J.; Billy, Bart D.; Kennedy, Kathy S.; Kupfer, David J.

doi:10.1093/sleep/20.10.858

Cited by 40 publications

(28 citation statements)

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“…Apart from the direct physical consequences of a severe locomotor disability there may be other sleep disrupting mechanisms as well. Monk et al . (1997) have shown that 17 days of continuous bed rest in the absence of day‐light flattens the amplitude of the core body temperature rhythm and leads to poorer subjectively rated sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Neurological impairments and sleep–wake behaviour among the mentally retarded

Lindblom

Heiskala

Kaski³

et al. 2001

Journal of Sleep Research

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The objective of the present study was to evaluate the relationship between the sleep–wake behaviour and neurological impairments among mentally retarded people. The sleep–wake behaviour of 293 mentally retarded subjects living in a rehabilitation center was studied by a standardized observation protocol carried out by trained staff members. The protocol consisted of brief check‐ups of the subjects’ sleep–wake status at 20‐min intervals for five randomly chosen 24‐h periods during 4 months. From the raw data five sleep–wake behaviour variables were formed. The data concerning the subject characteristics (age, body mass index (BMI), gender, degree of mental retardation, presence of locomotor disability, that of epilepsy, blindness or deafness and the usage of psychotropic medications) were collected from the medical records. Two main findings emerged: (1) severe locomotor disablity, blindness and active epilepsy were found to be independent predictors of increased daytime sleep and increased number of wake–sleep transitions and (2) the subjects with a combination of two or all three of these impairments had a significantly more fragmented and abnormally distributed sleep than those with none or milder forms of these impairments. Age, BMI, degree of mental retardation and the studied medications played a minor role in the sleep disturbances of the study population. Finally, deafness was not found to be associated with any of the measured sleep–wake variables.

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Section: Discussionmentioning

confidence: 99%

Neurological impairments and sleep–wake behaviour among the mentally retarded

Lindblom

Heiskala

Kaski³

et al. 2001

Journal of Sleep Research

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“…The main human body clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and the most important entraining factor of the clock is known to be environmental light (Duffy and Wright 2005). It has been shown, however, that in addition to the lighting conditions, factors such as prolonged bed rest and physical exercise may lead to changes in the human circadian rhythms (Mistlberger and Skene 2005;Monk et al 1997). It is probable that many ageing AGU adults often stay most of their day either in bed or otherwise physically inactive.…”

Section: Springermentioning

confidence: 99%

Sleep disturbances in aspartylglucosaminuria (AGU): A questionnaire study

Lindblom¹,

Kivinen

Heiskala

et al. 2006

J of Inher Metab Disea

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Sleep disturbances are common in many progressive metabolic encephalopathies. The possible presence of disturbed sleep-wake behaviour in the lysosomal storage disorder aspartylglucosaminuria, has not been previously studied, however. The sleep-wake behaviour of 81 patients with aspartylglucosaminuria (AGU, age 3-55 years, median 22 years; 42 female and 39 male) and 49 controls (age 2-57 years, median 18 years; 25 female and 24 male) was assessed through a postal survey. A slightly modified version of the validated Basic Nordic Sleep Questionnaire was used. Fifty-eight per cent of the AGU patients were reported to suffer daily from a sleep-related problem (controls 31%, p < 0.01). In AGU adults (age >17 years) and children (age ≤17 years), the corresponding figures were 52% and 61%, respectively (control children 22%, p < 0.05 and control adults 38%, p = 0.06). In AGU children, settling difficulties were reported to occur significantly more commonly than in control children. Children with AGU were also reported to snore more often than were the controls. Adults with this disorder were found to suffer from severely fragmented night-time sleep, which was experienced as highly distressing by the

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“…Yet despite over 50 years of bed-rest studies in humans, there is very little objectively-measured sleep data (Pavy-Le Traon et al, 2007). Of the few experimental studies investigating any sleep measure, many have not included baseline night recordings (Komada et al, 2006) or are confounded by experimental designs which manipulate circadian rhythm or light exposure (Monk et al, 1997), directly affecting sleep data. Thus, the effect of sustained bed rest on objective sleep parameters in healthy humans is not well known.…”

Section: Introductionmentioning

confidence: 99%

Bed Rest and Hypoxic Exposure Affect Sleep Architecture and Breathing Stability

et al. 2017

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Objective: Despite over 50 years of research on the physiological effects of sustained bed rest, data characterizing its effects on sleep macrostructure and breathing stability in humans are scarce. This study was conducted to determine the effects of continuous exposure to hypoxia and sustained best rest, both individually and combined, on nocturnal sleep and breathing stability.Methods: Eleven participants completed three randomized, counter-balanced, 21-days trials of: (1) normoxic bed rest (NBR, PIO2 = 133.1 ± 0.3), (2) hypoxic ambulatory confinement (HAMB, PIO2 = 90.0 ± 0.4) and (3) hypoxic bed rest (HBR, PIO2 = 90.0 ± 0.4; ~4,000 m equivalent altitude). Full objective polysomnography was performed at baseline, on Night 1 and Night 21 in each condition.Results: In NBR Night 1, more time was spent in light sleep (10 ± 2%) compared to baseline (8 ± 2%; p = 0.028); Slow-wave sleep (SWS) was reduced from baseline in the hypoxic-only trial by 18% (HAMB Night 21, p = 0.028) and further reduced by 33% (HBR Night 1, p = 0.010), and 36% (HBR Night 21, p = 0.008) when combined with bed rest. The apnea-hypopnea index doubled from Night 1 to Night 21 in HBR (32–62 events·h−1) and HAMB (31–59 events·h−1; p = 0.002). Those who experienced greatest breathing instability from Night 1 to Night 21 (NBR) were correlated to unchanged or higher (+1%) night SpO2 concentrations (R2 = 0.471, p = 0.020).Conclusion: Bed rest negatively affects sleep macrostructure, increases the apnea-hypopnea index, and worsens breathing stability, each independently exacerbated by continuous exposure to hypoxia.

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The Effects on Human Sleep and Circadian Rhythms of 17 Days of Continuous Bedrest in the Absence of Daylight

Cited by 40 publications

References 0 publications

Neurological impairments and sleep–wake behaviour among the mentally retarded

Neurological impairments and sleep–wake behaviour among the mentally retarded

Sleep disturbances in aspartylglucosaminuria (AGU): A questionnaire study

Bed Rest and Hypoxic Exposure Affect Sleep Architecture and Breathing Stability

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