The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy

The Predictors of Early Atherosclerosis in Young Adult Epileptic Patients

“…This modification of lipid profile is particularly significant among CBZ and polytherapy group than VPA group. Similar results were reported by other studies [17,18,19,20]. In this respect, it has been reported that chronic treatment with AEDs may compete with cholesterol in the utilization of hepatic microsomal enzymes P-450 system leading to reduction in the transformation of cholesterol to bile acids resulting in increase in serum cholesterol level [21] while Hsieh et al [22] reported that enzyme-inducing AEDs like CBZ increase the activity of the hepatic cytochrome P450 system, which is involved in synthesis of serum cholesterol, though direct studies are needed, our findings are wholly consistent with this hypothesis.…”

Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study

“…Epilepsy and prolonged antiepileptic drug treatment, particularly enzyme inducer AEDs have been found to induce hypercholesterolemia/dyslipidemia [12,13] and hyperuricemia [14]. It was found in this study that the level of HDL was significantly lower in the patients with epilepsy compared to the control group.…”

“…It was found in this study that the level of HDL was significantly lower in the patients with epilepsy compared to the control group. There were different studies having the same results [14][15][16]. Hamed et al [17] attributed the low levels of HDL-c to the altered metabolism of the major HDL-apolipoprotein A-I, and/or the effect of endogenous total cholesterol and LDL metabolism on HDL-c level in the epileptic patients.…”

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“…[4,11,12] Klasik antiepileptik ilaçlardan FB ve KBZ'nin total kolesterol, LDL ve HDL'yi artırdığı gösterilmiştir. [2][3][4][5]13,14] Yine enzim indükleyici olan FNT'ninde lipid profiline etkisi olduğu bilinmektedir, FNT'ninde özellikle LDL'yi arttırdığı bilinmektedir. [15] KBZ tedavisi okskarbazepin (OKBZ) ile değiştirildi-ğinde total kolesterol düzeylerinin ve karaciğer enzimlerinin düştüğü bildirilmiştir.…”

“…Daha önce-ki çalışmalarda, klasik antiepileptik ilaçlardan karbamazepin (KBZ), fenobarbital (FB), fenitoin (FNT) ve valproik asidin (VPA) lipid profili üzerine etkileri araştırılmıştır. [2][3][4][5] Klasik antiepileptik ilaçların karaciğerde p450 enzim sistemini indükleyerek hiperlipidemiye yol açacağı ve bunun da ateroskleroza zemin hazırlayabileceği bildirilmektedir. [4] Lamotrijin (LTG) 1991'den bu yana özellikle parsiyel epilepsilerde kullanılmaktadır.…”