The Effects on Myocardial Oxygen Availability of Hemorrhagic Hypotension and Its Reversal by Various Agents, Including L-Norepinephrine

Fs, Caliva; Napodano, Rudolph J.; Żurek, Rafał; Pombo, Teresa; Rh, Lyons

doi:10.1097/00000441-195909000-00006

Cited by 10 publications

(2 citation statements)

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“…The rise in systemic blood pressure demonstrated by both Attar et al (1962) and by Clark and Young (1964) would, of course, help by producing an increase in cerebral bloodflow. The oxygen tension of the myocardium has also been shown to drop drastically during haemorrhagic hypotension in the dog (Caliva et al, 1959), falling to near zero at a mean blood pressure of 20 mm Hg. Oxygen under pressure will therefore help here by the same mechanism as in the brain.…”

Section: Peripheral Circulatory Failurementioning

confidence: 99%

Hyperbaric Oxygen in Relation to Circulatory and Respiratory Emergencies

Mcdowall

1964

British Journal of Anaesthesia

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Section: Peripheral Circulatory Failurementioning

confidence: 99%

Hyperbaric Oxygen in Relation to Circulatory and Respiratory Emergencies

Mcdowall

1964

British Journal of Anaesthesia

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“…Cardiac output, stroke volume and coronary blood flow are reduced dur ing the oligemic phase of hemorrhagic shock [5,16,17]. Availability of oxygen to the myocardium is also decreased [2,16,17].Despite the fall in cardiac work during the period of hypotension, the reduction in oxygen supply to the myocardium and other tissues asso- …”

mentioning

confidence: 99%

The Relationship between Haemodynamic Changes and some Aspects of Cardiac Metabolism during Hemorrhagic Shock in the Unanaesthetized Dog

Marchetti¹,

Longo²,

Noseda³

et al. 1971

Eur Surg Res

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The haemodynamic pattern and myocardial oxygen, pyruvate and lactate metabolism elicited by experimental hemorrhagic shock in the unanaesthetized dog, in which electromagnetic flow-meters had previously been implanted around the circumflex branch of the left coronary artery and ascending aorta, catheters chronically-inserted into the aorta and coronary sinus, were studied. There were little changes in coronary blood flow, myocardial O₂-consumption, lactate and pyruvate blood levels, Δ-redox potential, Δ L/P or excess lactate before the blood pressure had dropped to irreversible shock level. When mean arterial pressure dropped to approximately 40 mm Hg, myocardial O₂-consumption and coronary blood flow fell abruptly, while lactate and pyruvate arterial and venous levels increased markedly; Δ-redox potential, Δ L/P and excess lactate values were unchanged or improved. This seems to indicate that even in irreversible shock there is no shift towards anaerobic metabolism of the heart.

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