The effects on nutritional status, bowel habits and tolerance of a high- protein, high-calorie, fiber- and fructo-oligosaccharide-enriched enteral formula: Safety and Effectiveness of Enteral Nutrition in Spanish patients (SENS Study).

Triana, Federico Miguel Cuesta; González, Francisco Villazón; París, Alejandro Sanz; Romero, Juan Ignacio Ramos-Clemente; Abizanda, José Enrique Palacio; Barriuso, Rebeca Sanz

doi:10.20960/nh.950

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…This improvement in nutritional status was also reflected in the evolution of the laboratory parameters, with a statistically significant improvement between baseline and 6 months (Table 5 ). These findings are consistent with a study of 102 patients (56.9% with HEN and 43.1% with hospital EN) treated with a hyperproteic/hypercaloric formula for 8 weeks, which also found improved weight, BMI, albumin and prealbumin parameters [ 21 ].…”

Section: Discussionsupporting

confidence: 92%

Impact of nutritional and educational support on home enteral nutrition

Madrid-Paredes

Leyva-Martínez

Ávila-Rubio

et al. 2023

J Health Popul Nutr

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Background Home Enteral Nutrition (HEN) is used to prevent or correct malnutrition in outpatients. Due to the complexity of this process, the indication, follow-up, and results of an educational program of HEN patients was evaluated. Methods A prospective, observational, real-life, multicenter study was performed in 21 Spanish Hospital. Patients receiving HEN by nasogastric tube or ostomy were included. The following variables were collected: age, gender, HEN indication, type of formula, nutritional requirements, laboratory variables, complications, and quality standards of the educational program. To calculate the energy and protein requirements, the FAO/WHO/UNU formula was used considering the adjusted weight of the patients. All data were analyzed using SPSS.24. Results 414 patients were included. Most conditions diagnosed were neurodegenerative diseases (64.8%). 100 (25.3%) were diabetic. The mean weight was 59.3 ± 10.4 kg and BMI 22.6 ± 3.2. Moderate protein-calorie malnutrition was predominant at baseline (46.4%). Improvement in nutritional status at six months was recorded in more than 75% of patients (p < 0.05). Tolerance problems, diarrhea and abdominal distension fell between the 3- and 6-month visits (p < 0.05). Patients who received intermittent EN had fewer tolerance-related effects (OR 0.042; 95% CI 0.006–0.279) and less diarrhoea (OR 0.042; 95% CI 0.006–0.279). At the baseline and 6-month visits, compliance with the educational measures proposed by the prescriber was ≥ 99%. Conclusion The nutritional assessment to prescribe individualized HEN to each patient, together with educational measures and training in the proper use of this treatment for both patients and trainers, improves nutritional status and reduces the onset of adverse events.

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Section: Discussionsupporting

confidence: 92%

Impact of nutritional and educational support on home enteral nutrition

Madrid-Paredes

Leyva-Martínez

Ávila-Rubio

et al. 2023

J Health Popul Nutr

View full text Add to dashboard Cite

show abstract

“…This improvement in nutritional status was also re ected in the evolution of the laboratory parameters, with a statistically signi cant improvement between baseline and 6 months (Table 5). These ndings are consistent with a study of 102 patients (56.9% with HEN and 43.1% with hospital EN) treated with a hyperproteic/hypercaloric formula for 8 weeks, which also found improved weight, BMI, albumin and prealbumin parameters [20].…”

Section: Discussionsupporting

confidence: 91%

Home Enteral Nutrition in Adults: Effectiveness of Nutritional Therapy and Educational Programme

Madrid-Paredes

Leyva-Martínez

Ávila-Rubio

et al. 2021

Preprint

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PurposeHome Enteral Nutrition (HEN) is used to prevent or correct malnutrition in outpatients. Due to the complexity of this process, the indication, follow-up, and results of an educational programme of HEN patients was evaluated.MethodsA prospective, observational, real-life, multicentre study of patients receiving HEN by nasogastric tube or ostomy in 21 hospitals was conducted. The following variables were collected: age, gender, HEN indication, type of formula, nutritional requirements, laboratory variables, complications, and quality standards of the educational programme. All data were analysed using SPSS.24.Results414 patients were included. Most conditions diagnosed were neurodegenerative diseases (64.8%). 100 patients (25.3%) were diabetic. The mean weight was 59.3±10.4kg and BMI 22.6±3.2. Moderate protein-calorie malnutrition was predominant at baseline (46.4%). Improvement in nutritional status at six months was recorded in more than 75% of patients (p<0.05). Tolerance problems, diarrhoea and abdominal distension fell between the 3- and 6-month visits (p <0.05). Patients who received intermittent Enteral Nutrition (EN) had fewer tolerance-related effects (OR: 0.042; 95% CI: 0.006-0.279) and less diarrhoea (OR: 0.042; 95% CI: 0.006-0.279), while those who received EN via nasogastric tube had fewer tolerance-related effects (OR: 0.042; 95% CI: 0.006-0.279). At the baseline and 6-month visits, compliance with the educational measures proposed by the prescriber was ≥ 99%. ConclusionThe nutritional assessment to prescribe individualised HEN to each patient, together with educational measures and training in the proper use of this treatment for both patients and trainers, improves nutritional status and reduces the onset of adverse reactions.

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“…The amount of the TRM in the study did not significantly change the GI symptoms in participants. Similarly, Cuesta-Triana reported that eight-week supplementation of fiber-containing formula (1.5 g fiber/100 g ONS) was well-tolerated by the subjects (Cuesta-Triana et al, 2017). In addition, the developed ONS supplementation also did not change the defecation frequency and stool form as evaluated by Bristol Stool Scale.…”

Section: Effect Of Developed Ons Supplementation On Gi Tolerabilitymentioning

confidence: 85%

Development of nutritionally complete oral nutritional supplement using tapioca maltodextrin as a carbohydrate source

Astina¹

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Carbohydrate is a major composition in oral nutrition supplement. Modification of carbohydrate composition using tapioca resistant maltodextrin (TRM) may improve the glycemic response. This study aimed to investigate the effect of TRM and TRM containing-ONS on glycemic response, satiety, and gastrointestinal (GI) tolerability in healthy individuals. Physicochemical properties and sensory evaluation of developed ONS were also investigated. In Phase I, the peak of plasma glucose and insulin response after TRM (50 g) ingestion was lowest compared to 50 g glucose (GL) and tapioca maltodextrin (TM) in 16 healthy participants. Peak of plasma glucose of TRM, GL, and TM were 104.60±2.63, 135.87±4.88, and 127.93±4.05 mg/dl, respectively, while peak of serum insulin was 13.001±2.12, 47.90±11.93, and 52.96±17.68 µIU/ml. No significant effects were observed on subjective appetite during 180 min of study. Fifty grams of TRM increased flatulence in healthy participants. In phase II, three formulas were developed: original (0 g TRM), RMD15 (2.7 g TRM), and RMD30 (5.4 g TRM). The RMD30 significantly had lowest viscosity (viscosity of original, RMD15, RMD30 were 36.37±0.25, 34.60±0.06, 34.07±0.09 cP, respectively) and highest water activity (0.35±0.01, 0.33±0.01, 0.37±0.01 respectively) compared to original formula. The overall acceptability scores of developed formula were more than 7. In phase III, seventeen healthy participants were included to examine the acute effect of 1 serving of three developed formulas on glycemic response and tolerability. The RMD30 formula showed lowest postprandial blood glucose compared to original and RMD 15 (113.33±4.44 vs 119.25±4.67 and 114.42±6.43 mg/dl, respectively). Meanwhile, the Area Under Curve of serum insulin in RMD30 group was lower by 33.1% compared to original group (2,320±570.76 vs 3,470.12±531.86 µIU/ml). Subjective appetite responses were not significantly different among three formulas. All formulas were well tolerated by healthy participants. In phase IV, RMD30 formula was chosen to be supplemented in normoglycemic and prediabetic participants. Bodyweight did not significantly change after ingestion of 1 serving/d of RMD30 for 3 weeks (66.56±3.66 vs 66.99±3.69 kg, p=0.069). Food intake significantly increased at week 3 following supplementation compared to baseline (1,144.87±87.10 vs 1,477.76±94.16 kcal, p=0.001), without affecting habitual food intake. There were no significant changes in gastrointestinal symptoms. In conclusion, TRM lowers the postprandial plasma glucose and insulin response in healthy participants. Incorporation of TRM in nutritionally complete ONS decreased viscosity and increased water activity, while increased the sensory acceptability score. The replacement of TM using TRM by 30% in ONS decreased the insulin response, without significantly affected the glucose and satiety. Supplementation of RMD30 daily for 3 weeks increased total food intake in healthy and prediabetic participants. Developed formula was well-tolerated in acute and three-weeks study.

show abstract

The effects on nutritional status, bowel habits and tolerance of a high- protein, high-calorie, fiber- and fructo-oligosaccharide-enriched enteral formula: Safety and Effectiveness of Enteral Nutrition in Spanish patients (SENS Study).

Cited by 4 publications

References 19 publications

Impact of nutritional and educational support on home enteral nutrition

Impact of nutritional and educational support on home enteral nutrition

Home Enteral Nutrition in Adults: Effectiveness of Nutritional Therapy and Educational Programme

Development of nutritionally complete oral nutritional supplement using tapioca maltodextrin as a carbohydrate source

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