The effects on pain and activity of daily living caused by crusted exudation in patients with head and neck cancer treated with cetuximab and radiotherapy

Russi, Elvio; Merlano, Marco; Numico, Gianmauro; Corvò, Renzo; Benasso, Marco; Vigna‐Taglianti, Riccardo; Melano, Antonella; Denaro, Nerina; Pergolizzi, Stefano; Colantonio, I.; Lucio, Francesco; Brizio, Rodolfo; Ricardi, Umberto

doi:10.1007/s00520-011-1324-4

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…Hyperpigmentation is a result of radiation-induced stimulation of epidermal melanocytes. Furthermore, the association of cetuximab to radiotherapy can induce crusts which cause cutaneous painful microwounds during therapy [6]. …”

Section: Introductionmentioning

confidence: 99%

Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature

Häfner

Fetzner²,

Hassel³

et al. 2013

Dermatology

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Radiodermatitis is a very common side effect in cancer treatment often leading to therapy delays and diminution of the patients' health state and quality of life. Despite a wide range of supportive strategies, radiodermatitis is still a major problem necessitating further improvements in prevention and treatment. Lactokine is a milk-based protein shown to assist in the reduction of skin redness. The treatment is a unique FDA-approved skin care system (R1 and R2). In this case presentation we describe the prophylactic use of R1 and R2 in a 63-year-old, female patient with a squamous cell carcinoma of the hypopharynx undergoing a platin-based chemoradiation. The application was feasible and safe and the patient developed only a slight radiodermatitis. To our knowledge this is the first report in the literature on the prophylactic use of R1 and R2. Further evidence will be provided by a prospective, clinical trial we have launched (CREAM-1; study registration in ISRCTN Registry: ISRCTN87302591). We also review the literature to give an overview about common strategies in the management of radiodermatitis.

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Section: Introductionmentioning

confidence: 99%

Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature

Häfner

Fetzner²,

Hassel³

et al. 2013

Dermatology

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“…These crusts might adhere to the skin, cause damage and provoke bleeding and/or pain [21]. The reparative capacity of damaged skin might also be compromised, rendering the cutis itself prone to abrasion.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Papulopustular eruption consists of erythematous follicular papules which may potentially evolve into pustules. Lesions may coalesce into plaques covered by yellow crusts [21]. Frequent infection of these lesions has been described [20].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…There is general agreement that a clear and objective nomenclature for grading Cet-related radiation dermatitis is still lacking [21,26,30,31]. To our knowledge, the only scale that tries to overcome this limitation has been the one proposed by Bernier et al [13].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…In this case, it is necessary to perform the debridement of crusts to reduce the risk of superinfection and bleeding and to help reduce pain [13,15,21]. …”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Management of ‘In-Field' Skin Toxicity in Head and Neck Cancer Patients Treated with Combined Cetuximab and Radiotherapy

et al. 2013

Self Cite

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It is well known that the cetuximab (Cet) epidermal growth factor receptor (EGFR) antibody enhances the sensitivity of tumour cells to radiation, and it is likely that the concurrent administration of Cet and radiotherapy (RT) results in some degree of interplay between the effects of the individual agents on the skin and in the exacerbation of reactions normally seen with these individual agents. In this paper, we present a concise review of Cet/RT-related skin toxicity, focusing on mechanisms and pathogenesis, clinical presentation and scoring systems and, finally, therapeutic management.

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Management of severe bio-radiation dermatitis induced by radiotherapy and cetuximab in patients with head and neck cancer: emphasizing the role of calcium alginate dressings

Bonomo

Desideri

Loi

et al. 2018

Support Care Cancer

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The effects on pain and activity of daily living caused by crusted exudation in patients with head and neck cancer treated with cetuximab and radiotherapy

Abstract: Crusts have the strongest correlation with pain in patients with Cetuximab-related radiation dermatitis. Moreover, the presence of crusts can lead operators to misclassify dermatitis as score 4, causing unnecessary delays or interruptions in treatment.

Cited by 9 publications

References 25 publications

Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature

Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature

Management of ‘In-Field' Skin Toxicity in Head and Neck Cancer Patients Treated with Combined Cetuximab and Radiotherapy

Management of severe bio-radiation dermatitis induced by radiotherapy and cetuximab in patients with head and neck cancer: emphasizing the role of calcium alginate dressings

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