The effects on speech and language of stereotactical stimulation in thalamus and corpus callosum

Schaltenbrand, Georg

doi:10.1016/s0093-934x(75)80055-1

Cited by 110 publications

(25 citation statements)

References 8 publications

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“…In our study, speech as indicated by item 18 of the UPDRS, was worsened by Vim stimulation. This estimation confirmed several previous observations: Guiot et al [30]noted that stimulation in the course of stereotaxic procedures could modify speech either by suddenly stopping it or by accelerating its rate; Schaltenbrand [31]noticed interruption of speech as well as alterations in articulation during stimulation of the thalamus. Dysarthria was also observed with chronic electrical stimulation of the Vim [32].…”

Section: Discussionsupporting

confidence: 91%

Effect of Bilateral Deep-Brain Stimulation on Oral Control of Patients with Parkinsonism

et al. 2000

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We assessed the oral system of parkinsonian patients treated with bilateral chronic stimulation of the ventral intermediate nucleus of the thalamus (Vim), and of the subthalamic nucleus (STN) to compare the effects of these procedures on the articulatory organs. Force transducers were used to sample ramp-and-hold force contractions generated by the upper lip, lower lip and tongue at 1- and 2-newton target force levels, as well as maximal force. Fourteen healthy control subjects and 14 parkinsonian patients participated in this study. After an overnight fast the patients were evaluated under two conditions: during bilateral stimulation and 1 h after stopping stimulation. With Vim stimulation, dynamic and static control of the articulatory organs was worsened while with STN stimulation it was greatly improved. The target of stimulation differently influences the oral system and modulates neuronal structures involved in speech.

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Section: Discussionsupporting

confidence: 91%

Effect of Bilateral Deep-Brain Stimulation on Oral Control of Patients with Parkinsonism

et al. 2000

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“…Stimulation of the dominant thalamus can produce speech slowing (e.g., Schaltenbrand, 1975; Mateer, 1978) while bilateral ablation of this structure can produce pathologically rapid speech (Canter and Van Lancker, 1985). The relationship between syllable repetition rate and left thalamic blood flow in the present analysis is consistent with these clinical observations if we view the reduction in blood flow as reflecting neurophysiological function that is opposite of that which occurs with electrical stimulation.…”

Section: Discussionmentioning

confidence: 99%

Performance-based connectivity analysis: A path to convergence with clinical studies

Sidtis

2012

NeuroImage

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Connectivity analyses have become increasingly important in functional imaging. When used to describe the functional anatomy of a specific behavior, these analyses are generally applied to a subset of the data that demonstrate significant differences when experimental conditions are contrasted. Such data reduction is sub-optimal for a systems approach as it assumes that all data that survive the statistical contrast filter are related to the behavior and that none of the filtered data have a significant function. When such data filtering is applied to speech and language tasks, the resulting functional anatomy rarely reflects the brain lateralization established in over a century and a half of clinical studies. A two-step performance-based connectivity analysis is described in which the first step uses multiple linear regression to establish a direct relationship between regional brain activity and a measure of performance. The second step uses partial correlations to examine the functional relationships between the predictor regions and other brain regions. When applied to regional cerebral blood flow data obtained with positron emission tomography during a speech production task, the results demonstrate left lateralization of motor control areas, thalamic involvement in repetition rate, and auditory cortical suppression, all consistent with clinical observations. The integration of performance measures into the earliest stages of image analysis without reliance on data filtering based on decomposition may provide a path towards convergence with traditional descriptions of functional anatomy based on clinical studies.

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“…Stimulation of the thalamus has been reported to produce silencing and slowing of speech [41], while stimulation of the left ventrolateral thalamus causes alterations in object naming in the form of agnosia, perseveration and anomia [42]. As yet the effect of stimulation of the STN on speech has not been determined although preliminary findings based on physiological studies of patients with implanted thalamic stimulators suggest that such stimulation has deleterious effects on speech.…”

Section: Effect Of Pallidotomy Thalamotomy and Deep Brain Stimulatiomentioning

confidence: 99%

Subcortical Brain Mechanisms in Speech and Language

Murdoch¹

2001

Folia Phoniatr Logop

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This paper reviews current research and contemporary theories of subcortical participation in the motor control of speech production and language processing. As a necessary precursor to the discussion of the functional roles of the basal ganglia and thalamus, the neuroanatomy of the basal ganglial-thalamocortical circuitry is described. Contemporary models of hypokinetic and hyperkinetic movement disorders based on recent neuroanatomical descriptions of the multi-segmented circuits that characterise basal ganglion anatomy are described. Reported effects of surgically induced lesions in the globus pallidus and thalamus on speech production are reviewed. In addition, contemporary models proposed to explain the possible contribution of various subcortical structures to language processing are described and discussed in the context of evidence gained from observation of the effects of circumscribed surgically induced lesions in the basal ganglia and thalamus on language function. The potential of studies based on examination of the speech/language outcomes of patients undergoing pallidotomy and thalamotomy to further inform the debate relating to the role of subcortical structures in speech motor control and language processing is highlighted.

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The effects on speech and language of stereotactical stimulation in thalamus and corpus callosum

Cited by 110 publications

References 8 publications

Effect of Bilateral Deep-Brain Stimulation on Oral Control of Patients with Parkinsonism

Effect of Bilateral Deep-Brain Stimulation on Oral Control of Patients with Parkinsonism

Performance-based connectivity analysis: A path to convergence with clinical studies

Subcortical Brain Mechanisms in Speech and Language

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