The efficacy and safety of combined traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure: a systematic review and meta-analysis study

Huang, Peifen; Lin, Xin; Liu, Yin; Hou, Zhengjun

doi:10.21037/apm-22-272

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TCM deals with underlying causes as well as manifest symptoms, while Western medicine provides complementary treatment support that halts disease progression and maintains physiological functions. In comparison to Western medicine monotherapy, this integrative approach can improve patients' physiological status and improve their prognosis [21,22]. One month after treatment, the experimental group showed lower levels of CRP, WBC and N than the control group.…”

Section: Discussionmentioning

confidence: 99%

Investigating the effects of Qingre Lifei decoction combined with terbutaline in treating male patients with acute exacerbation of chronic obstructive pulmonary disease

2024

JOMH

View full text Add to dashboard Cite

This study aimed to evaluate the therapeutic efficacy of Qingre Lifei decoction combined with terbutaline in men suffering from acute exacerbation of chronic obstructive pulmonary disease (COPD). 100 male patients with COPD acute exacerbation admitted to our hospital between May 2020 and May 2023, were enrolled and randomly assigned to an experimental group and a control group (n = 50 each) based on a computergenerated randomization table. As a control treatment, a terbutaline nebulizer solution was inhaled alongside with conventional Western medicine. The experimental group additionally received Qingre Lifei Decoction. A comparison was made between the therapeutic effects of the two treatment methods. The experimental group exhibited a significantly higher overall effective rate than the control group (p < 0.05). One month after treatment, the experimental group showed significantly higher forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1/FVC ratios than the control group (p < 0.05). C-reactive protein (CRP), white blood cells (WBC), and neutrophils (N) in the experimental group were significantly lower than the control group one month after treatment (p < 0.05). Compared to controls, the arterial oxygen partial pressure (PaO 2 ) and oxygen saturation (SaO 2 ) levels in the experimental group were significantly higher, and the carbon dioxide partial pressure (PaCO 2 ) levels were significantly lower (p < 0.05). Adverse drug reactions incidence did not differ between both groups (p > 0.05). In men with acute exacerbations of COPD, Qingre Lifei decoction combined with terbutaline nebulization can be effective in improving breathing symptoms and functional ventilation. It is safe and worthy of wider clinical promotion.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating the effects of Qingre Lifei decoction combined with terbutaline in treating male patients with acute exacerbation of chronic obstructive pulmonary disease

2024

JOMH

View full text Add to dashboard Cite

show abstract

“…The results of this study are consistent with those of previous studies that reported the beneficial effects of acetylcysteine inhalation on AECOPD. A meta-analysis of several randomized controlled trials on AECOPD found that acetylcysteine inhalation significantly reduced the length of hospital stay, risk of treatment failure, and mortality rate compared with placebo or standard therapy[ 31 ]. Another meta-analysis involving patients with AECOPD found that acetylcysteine inhalation significantly improved lung function, arterial blood gas parameters, and clinical symptoms compared with placebo or standard therapy[ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

Huang,

et al. 2024

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a serious complication of chronic obstructive pulmonary disease, often characterized by increased morbidity and mortality. In traditional Chinese medicine, AECOPD is linked to phlegm-heat and blood-stasis, presenting symptoms like thick sputum, fever, and chest pain. It has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD, suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type AECOPD. AIM To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type AECOPD. METHODS One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two groups. The treatment group received acetylcysteine inhalation (10% solution, 5 mL, twice daily) along with conventional therapy, whereas the control group received only conventional therapy. The treatment duration was 14 d. Inflammatory markers (C-reactive protein, interleukin-6, and tumor necrosis factor-alpha) in the serum and sputum as well as lung function parameters (forced expiratory volume in one second, forced vital capacity, and peak expiratory flow) were assessed pre- and post-treatment. Acetylcysteine inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group (P < 0.05). This suggests that acetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type AECOPD. RESULTS Acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control group. These differences were statistically significant (P < 0.05). The study concluded that acetylcysteine inhalation had a positive effect on microinflammation and lung ventilation function in patients with this type of AECOPD, suggesting its potential as an adjuvant therapy for such cases. CONCLUSION Acetylcysteine inhalation demonstrated significant improvements in reducing inflammatory markers in the serum and sputum, as well as enhancing lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD. These findings suggest that acetylcysteine could serve as a valuable adjuvant therapy for individuals with this specific type of AECOPD, offering benefits for managing microinflammation and optimizing lung function.

show abstract

“…Astragalus injection is a traditional Chinese medicine injection that can be used in conjunction with conventional treatment to aid in the treatment of COPD 3 , 4 . The combination of traditional Chinese medicine preparation and conventional treatment can reduce the number of acute exacerbations of COPD and improve the clinical efficacy of COPD treatment 5 , 6 . Clinical researchers in China have used astragalus injection in combination with ambroxol hydrochloride as an adjuvant treatment for COPD 7 .…”

Section: Introductionmentioning

confidence: 99%

The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis

Zhou,

Yang,

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a severe condition that leads to premature mortality and places a significant financial burden on healthcare systems. An adjunctive therapy in COPD includes the simultaneous administration of astragalus injection and ambroxol hydrochloride. Despite its widespread use, the effectiveness of this combined approach in COPD treatment has not been systematically evaluated. Thus, we conducted a systematic review and meta-analysis to assess the efficacy of combining astragalus injection with ambroxol hydrochloride as an adjuvant treatment for COPD. Six electronic databases were used to search for relevant randomized controlled trials, and data analysis was conducted using Review Manager 5.4. A total of 14 randomized controlled trials were included, involving 1070 patients who met the criteria. The results of the meta-analysis indicated that the combination of astragalus injection with ambroxol hydrochloride as an adjuvant treatment can improve various clinical parameters in patients with COPD compared to conventional treatment alone. These parameters include the clinical effective rate (OR = 5.44, 95% CI 3.51–8.43, I2 = 0%), partial pressure of oxygen in artery (MD = 1.12, 95% CI 0.87–1.36, I2 = 5%), partial pressure of carbon dioxide in artery (MD = − 1.43, 95% CI − 1.65 to − 1.21, I2 = 0%), forced expiratory volume in one second (MD = 0.30, 95% CI 0.18–0.42, I2 = 0%), percentage of forced expiratory volume in one second (MD = 16.18, 95% CI 12.60–19.76, I2 = 82%), forced vital capacity (MD = 0.33, 95% CI 0.21–0.45, I2 = 36%), hemoglobin (MD = − 16.17, 95% CI − 20.84 to − 11.51, I2 = 29%), and the ratio of forced expiratory volume in one second to forced vital capacity (MD = 2.51, 95% CI − 0.05 to 5.06, I2 = 0%). The combination of astragalus injection and ambroxol hydrochloride could be a selection of COPD patients as an adjuvant treatment. However, further validation is required to evaluate the effectiveness of combining astragalus injection and ambroxol hydrochloride as an adjunctive treatment for patients with COPD.

show abstract

The efficacy and safety of combined traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure: a systematic review and meta-analysis study

Cited by 5 publications

References 0 publications

Investigating the effects of Qingre Lifei decoction combined with terbutaline in treating male patients with acute exacerbation of chronic obstructive pulmonary disease

Investigating the effects of Qingre Lifei decoction combined with terbutaline in treating male patients with acute exacerbation of chronic obstructive pulmonary disease

Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis

Contact Info

Product

Resources

About