The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

Abstract

Background. Bisoprolol is commonly used to treat moderate or severe chronic stable heart failure, coronary heart disease, and hypertension. This study is aimed at analyzing the efficacy of bisoprolol in the treatment of myocardial infarction with cardiac insufficiency and its effect on cardiac function, Hcy, and CRP through meta-analysis. Methods. A total of 120 patients with myocardial infarction and cardiac insufficiency from February 2020 to February 2021 were selected and randomly divided into two groups (control and the observation, n = 60 ) according to the random number table method. The control group was given conventional treatment. The observation group was given bisoprolol on the basis of control group. The clinical efficacy, systolic blood pressure, diastolic blood pressure, heart rate, cardiac function indexes, homocysteine (Hcy), and C-reactive protein (CRP) levels were compared between the two groups before and after treatment through data analysis. Adverse reactions were observed during treatment. Results. Compared with the control group, the total effective rate of the observation group was significantly increased ( p < 0.05 ). After treatment, the levels of heart rate, left ventricular end-diastolic volume (LVEDV), and left ventricular end-systolic volume (LVESV) and serum Hcy and CRP levels in the observation group were significantly lower than those in the control group ( p < 0.05 ). Meanwhile, left ventricular ejection fraction (LVEF) level in the observation group after treatment was higher than that of the control group ( p < 0.05 ). Conclusion. Bisoprolol combined with conventional treatment can reduce serum Hcy and CRP levels in patients with myocardial infarction and cardiac insufficiency and improve cardiac function. Moreover, there are no obvious adverse reactions during the treatment.

Effect of Atorvastatin Calcium Combined with Sakubatravalsartan in Coronary Heart Disease Complicated with Cardiac Insufficiency

“…and promoting the production of human insulin, thus resisting human inflammation, improving vascular sclerosis, increasing the blood supply function of the heart, avoiding myocardial hypoxia and regulating the state of smooth muscle, making the heart gangrene partially regenerate, expanding the coronary vessels of the heart, and dredging the blood accumulated in the pulmonary circulation, make blood circulation more smooth, so as to improve left heart function. Sacubitril-valsartan is a new type of angiotensin-enkephalin inhibitor [24,25] . Patients can degrade the natriuretic peptide after taking it orally, so as to improve the level of natriuretic peptide in the body, and then play the role of water excretion, vasodilation and inhibition of sympathetic system [26] .…”

Retracted: The Efficacy and Safety of Bisoprolol in the Treatment of Myocardial Infarction with Cardiac Insufficiency

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”