The Efficacy and Safety of Venlafaxine in the Prophylaxis of Migraine

Özyalçín, Süleyman; Talu, Gül Köknel; Kiziltan, Emre; Yücel, Başak; Ertaş, Mustafa; Dişçi, Rian

doi:10.1111/j.1526-4610.2005.05029.x

Cited by 189 publications

(117 citation statements)

References 28 publications

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“…AEs include increased appetite, weight gain, dry mouth and sedation; cardiac toxicity and orthostatic hypotension occasionally occur. Selective 5-HT reuptake inhibitors (SSRIs) are probably not effective at preventing migraine, whereas the results of open and smaller studies indicate that selective norepinephrinereuptake inhibitors (SNRIs) are effective [19]. The mechanism by which antidepressants prevent headache is unclear but it does not result from treating masked depression.…”

Section: Antidepressantsmentioning

confidence: 97%

Preventive treatment of migraine

Silberstein

2006

Trends in Pharmacological Sciences

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Section: Antidepressantsmentioning

confidence: 97%

Preventive treatment of migraine

Silberstein

2006

Trends in Pharmacological Sciences

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“…The results of the study indicated that venlafaxine was more effective compared to placebo in migraine prophylaxis and considered a well-tolerated drug. [12] In another study conducted to investigate the effectiveness of venlafaxine and amitriptyline in migraine prophylaxis, both were found to be significantly effective in reducing pain parameters but the side effect profile of venlafaxine was found superior when compared to that of amitriptyline. [13] Similar to the results of this study, our study recorded a decrease in pain intensity, frequency and duration after venlafaxine intake (75-225 mg/day).…”

Section: Discussionmentioning

confidence: 99%

The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels

Biçer¹

2017

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the efficacy of acupuncture in preventing migraine attacks. Patients and methods:Between December 2013 and June 2014, a total of 54 patients with a diagnosis of migraine in our neurology clinic were randomized into two groups. Venlafaxine was administered for three months to one group (drug therapy group: 4 males, 21 females; mean age 32.0±9.1 years; range, 18 to 65 years), while the other group was treated with acupuncture (acupuncture group: 5 males, 24 females; mean age 30.3±7.4 years; range, 18 to 65 years). The control group consisted of a total of 29 healthy individuals (7 males, 22 females; mean age 30.3±7.4 years; range 18 to 65 years). Blood serotonin levels were assessed before and after treatment along with visual analog scale (VAS) and Migraine Disability Assessment (MIDAS) in both groups. Results:There was no statistically significant difference in the mean analgesic use before and after the treatment and VAS and MIDAS scores between the acupuncture and drug therapy groups (p>0.05). The number and duration of attacks was found to be significantly lower in both groups, compared to the pre-treatment values (p<0.0001). The serotonin levels in the acupuncture and drug therapy groups were significantly higher compared to the pre-treatment values (p<0.001). Serotonin levels were found to be significantly lower in healthy individuals compared to the study groups (p<0.0001). Conclusion:Based on our study findings, acupuncture may be an effective option in the migraine prophylaxis. Bulgular: Akupunktur ve ilaç grubu arasında tedavi öncesi ve sonrası ortalama analjezik ilaç kullanımı ve GAÖ ve MIDAS skorları açısından istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Atak sayı ve süresi, her iki grupta da tedavi öncesi değerlere kıyasla, anlamlı düzeyde düşük bulundu (p<0.0001). Akupunktur ve ilaç grubunda serotonin düzeyleri, tedavi öncesi değerlere kıyasla, anlamlı düzeyde yüksekti (p<0.0001). Çalışma gruplarına kıyasla, sağlıklı bireylerin serotonin düzeyleri, anlamlı düzeyde düşük bulundu (p<0.0001).Sonuç: Çalışma bulgularımıza göre, akupunktur, migren profilaksisinde etkili bir seçenek olabilir.Anahtar sözcükler: Akupunktur; migren; serotonin.

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“…Trials of venlafaxine have shown that a 150-mg dosage is superior to placebo 34 for prevention of migraine, with a median reduction of four days with migraine in the last two weeks of therapy compared to the first two weeks. Antidepressants should be considered for prophylaxis of migraine in patients with a coexisting anxiety or mood disorder.…”

Section: Antidepressantsmentioning

confidence: 99%

Prophylaxis of migraine headache

Pringsheim

Davenport²,

Becker³

2010

Canadian Medical Association Journal

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Key points• The choice of prophylactic therapy for migraine is based on existing comorbidities, contraindications, reported efficacy, and adverse effect profiles.• Prophylaxis should be considered for patients whose migraines affect their quality of life despite appropriate symptomatic treatment, or who are at risk for medication overuse headache.• The period that successful migraine prophylaxis should be continued is not clear; patients should be followed up regularly to ensure that their medication is still beneficial.

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The Efficacy and Safety of Venlafaxine in the Prophylaxis of Migraine

Abstract: Venlafaxine was more effective than placebo and is safe and well tolerated as migraine prophylaxis.

Cited by 189 publications

References 28 publications

Preventive treatment of migraine

Preventive treatment of migraine

The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels

Prophylaxis of migraine headache

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