The efficacy and safety of epidermal growth factor in treatment of diabetic foot ulcers: the preliminary results

Tuyet, Hoa Le; Quynh, Tram Tran Nguyen; Minh, Hien Vo Hoang; Bich, Dao Nguyen Thi; Dinh, Thang Do; Tan, Duc Le; Van, Hoang Lam; Huy, Truong Le; Huu, Hau Doan; Trong, Tri Nguyen Tran

doi:10.1111/j.1742-481x.2009.00594.x

Cited by 69 publications

(51 citation statements)

References 7 publications

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“…Diğer bir büyüme faktörü olan epidermal büyüme faktö-rü (EGF)'nün topikal uygulamayla DA yaralarında kapanma oranını artırdığı (152)(153)(154), kapanma süresini kısalttığı ve gü-venli bir uygulama olduğu ortaya konmuştur (155,156). İntra-lezyonel olarak uygulanan EGF'nin özellikle iskemik karakterli DA yaralarında yara iyileşme oranlarını artırdığı, iyileşme sü-resini kısalttığı ve ampütasyon riskini azalttığı, ürünün üre-tildiği ülkede yapılan bir dizi çalışmayla gösterilmiştir (157)(158)(159)(160)(161).…”

Section: Soru 7: Ozon Uygulamasının Diyabetik Ayak Yaralarının Tedaviunclassified

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Saltoğlu¹,

Kılıçoğlu²,

Baktiroğlu³

et al. 2016

Klimik Dergisi

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Study Group for Diabetic Foot Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases has called for collaboration of the relevant specialist societies and the Ministry of Health to issue a national consensus report on the diagnosis, treatment and prevention of diabetic foot (DF) wounds and diabetic foot infections (DFIs) in Turkey. In the periodical meetings of the assigned representatives from all the parties, various questions as to pathogenesis, microbiology, assessment and grading, treatment, prevention and control of diabetic foot were identified. Upon reviewing related literature and international guidelines, these questions were provided

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Section: Soru 7: Ozon Uygulamasının Diyabetik Ayak Yaralarının Tedaviunclassified

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Saltoğlu¹,

Kılıçoğlu²,

Baktiroğlu³

et al. 2016

Klimik Dergisi

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“…Yapılan pekçok çalışmada VAC'ın yarada granülasyon dokusu gelişim zamanını azalttığı, yara iyileşme süresini kısalttığı, yara kapamasını hızlandırdığı ve ampütasyon oranlarını azalttığı gösterilmiştir (15,16). Diğer bir yardımcı kapama yöntemi olan EGF'in topikal uygulamasıyla DA yaralarında kapanma oranlarının arttığı, kapanma süresinin kısaldığı ve güvenli bir uygulama olduğu yapılan çalışmalarla ortaya konmuştur (17,18)…”

Section: Discussionunclassified

Our Diabetic Foot Infections We Followed Accompanied By Alternative Methods

Bozkurt¹,

Alan²,

Dayan³

et al. 2017

Van Med J

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ÖZETAmaç: Diyabetik ayak enfeksiyonları multidisipliner yaklaşım ve yoğun bir emek gerektirmesi açısından ayrı bir önem arz etmektedir. Halen hastaların organize takibi açısından pekçok hastanede sıkıntılar yaşanmaktadır. Benzer sıkıntıları yaşayan bir Üniversite Hastanesi olarak diyabetik ayak konseyi eşliğinde takip ettiğimiz hasta deneyimlerimizi paylaşmayı amaçladık.

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“…The rEGF products available from various expression activities were analyzed for their efficacies in promoting treatments of skin diseases, including hard-to-heal wounds such as diabetic foot ulcers [25][26][27][28], bedsores [29], scalds [30] and Stevens-Johnson syndrome [31], of which the last disorder results usually from a severe allergic reaction to a medication [32][33]. Despite the positive outcomes shown in these studies, the efficacies of EGF as an active ingredient in skin care or medical applications have been controversial, in particular in studies conducted in earlier times [34].…”

Section: Disparities In Performance Among Different Regf Isoformsmentioning

confidence: 99%

Untitled

2017

JAPLR

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Human epidermal growth factor (EGF) is a functionally versatile polypeptide comprising 53 amino acids (aa). Due to the ability of EGF to stimulate epidermal growth and proliferation, numerous research studies have been conducted to explore its potential applications in cosmetic, skin care and medication. The emergence of recombinant DNA technology has facilitated the production of a great variety of recombinant EGF (rEGF) isoforms. However, increasing evidence supports that rEGF isoforms exhibit different levels of stability and potency. This review discusses how the less bioactive rEGF isoforms may mystify the identity and even the functional properties of authentic rEGF, which shares the same primary structure as native EGF. The identity crisis, the time-consuming, costly and labor-intensive patenting and drug regulatory processes act together to result in underrating the functional applications of authentic rEGF, which have been shown to be effective and safe in promoting treatments of a variety of skin disorders such as diabetic foot ulcers (DFU).

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The efficacy and safety of epidermal growth factor in treatment of diabetic foot ulcers: the preliminary results

Abstract: Easyef has positive effects on healing of moderate-to-severe foot ulcers and demonstrated being safe to diabetic patients. The drug had high tolerability and compliance.

Cited by 69 publications

References 7 publications

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Our Diabetic Foot Infections We Followed Accompanied By Alternative Methods

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