The efficacy and safety of a fractional microneedle radiofrequency device for the treatment of axillary hyperhidrosis: clinical prospective pilot study

Jung, Joon Min; Na, Hyoung Min; Kim, Jung Ho; Yoon, Jihae; Yang, Hee Joo; Lee, Woojin; Chang, Sung Eun; Lee, Mi Woo; Won, Chong Hyun

doi:10.1007/s10103-021-03404-z

Cited by 4 publications

(3 citation statements)

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“…36 The present study was designed to test the efficacy of a single Nd:YAG laser or IPL treatment in the attempt to provide a realistic alternative to microwave therapy, [14][15][16][17] subdermal laser therapies, [19][20][21][22] and other emerging therapies. 37 The external Nd:YAG laser or IPL treatment of PAH proved safe while one treatment session did not provide lasting efficacy on sweat secretion and therefore, the trial should have been extended to several repeated treatments as seen in the pilot study by Letada et al 18 In the present study, patients reported VAS pain of median 6.15 (IQ range: 5.80−6.85) and fluences were therefore not increased further. Applied pulse widths of 20 mS were the widest commercially available in the operator settings of the device, yet, even longer pulse widths might have induced more heat diffusion and thus a stronger effect on the eccrine sweat glands.…”

Section: Discussionmentioning

confidence: 65%

“…In contrast, a single prospective uncontrolled study demonstrated increased sweat secretion following 6−10 external Nd:YAG laser treatments of excessive hair growth 36 . The present study was designed to test the efficacy of a single Nd:YAG laser or IPL treatment in the attempt to provide a realistic alternative to microwave therapy, 14–17 subdermal laser therapies, 19–22 and other emerging therapies 37 . The external Nd:YAG laser or IPL treatment of PAH proved safe while one treatment session did not provide lasting efficacy on sweat secretion and therefore, the trial should have been extended to several repeated treatments as seen in the pilot study by Letada et al 18…”

Section: Discussionmentioning

confidence: 99%

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Attempted treatment of primary axillary hyperhidrosis with one session of either Neodymium YAG laser or Intense Pulsed Light: A within patient randomized trial of treated versus untreated contralateral axilla

et al. 2023

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BackgroundPrimary axillary hyperhidrosis (PAH) affects 1−5% of the world's population who has an unmet need for improved treatments. The heating of sweat glands with specific microwave therapy has shown promising results, yet, treatment with widely available devices such as long‐pulsed Neodymium Yttrium Aluminum Garnet (Nd:YAG) lasers, diode lasers or Intense Pulsed Light (IPL) may serve as pragmatic alternatives.ObjectivesTo compare sweat secretion of treated versus untreated contralateral control axilla 1−3 months after one session of Nd:YAG laser or IPL in patients with PAH.MethodsA within‐person randomized controlled trial. Patients were randomized to receive either one session of Nd:YAG laser or IPL in one axilla with the contra‐lateral serving as control. Sweat production was assessed by gravimetry, trans‐epidermal water loss, hyperhidrosis disease severity scale and dynamic optical coherence tomography. Mixed‐effects models were used to handle the within‐person design, containing both fixed effect factors (side, group, and subgroup), and random effects (patients), while also adjusting for the level at baseline.ResultsA total of 20 patients were enrolled. At follow‐up 1−3 months after treatment, sweat secretion was not affected in the treated axilla when compared to the control axillae (0.01 [95%CI: −0.04 to 0.05]; p = 0.68). In the Nd:YAG subgroup (10 patients), least squares means for sweat secretion was 0.18 mg/5 min in the treated versus 0.15 mg/5 min in the control axilla, respectively, corresponding to a statistically insignificant mean difference of 0.02 mg/5 min (95% CI: −0.06 to 0.11; p = 0.54). In the IPL subgroup (10 patients), sweat secretion was 0.06 mg/5 min in the treated axilla versus 0.07 mg/5 min in the control axilla with a statistically insignificant difference of –0.01 points (95% CI: −0.03 to 0.02; p = 0.46). Likewise, none of the secondary outcomes were significantly affected by treatment. However, both treatments appeared safe and well tolerated with no adverse effects reported at follow‐up.ConclusionsOne treatment with external 1064 nm Nd:YAG laser or 640 nm IPL at commercially available settings, failed to demonstrate clinical benefit in treating PAH, with narrow confidence intervals implying that this was not due to a type‐2 error.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Attempted treatment of primary axillary hyperhidrosis with one session of either Neodymium YAG laser or Intense Pulsed Light: A within patient randomized trial of treated versus untreated contralateral axilla

et al. 2023

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“…Besides, microneedling has also been tried. [36] Lasers Nd:YAG 1064 nm and other lasers show significant reduction in hyperhidrosis when associated with surgical excision of the glands. [37][38][39][40][41][42]…”

Section: Cryotherapymentioning

confidence: 99%