The Efficacy and Safety of Botulinum Toxin Type A Injections in Improving Facial Scars: A Systematic Review and Meta-Analysis

Wang, Wendi; Liu, Guangjing; Li, Xiaobing

doi:10.1159/000522396

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…None of the studies reported serious adverse events. Based on the results, botulinum toxin type-A showed favorable safety when used to treat facial scars (Wang et al, 2022). In another work carried out by Goodman and collaborators (2020), the safety assessment of the use of botulinum toxin for aesthetic purposes was also positive.…”

Section: Discussionmentioning

confidence: 98%

COMPLICATIONS AND SAFETY IN THE USE OF BOTULINUM TOXIN TYPE-A (BoNT-A) FOR AESTHETIC PURPOSES

Firmino

2023

JHS

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Botulinum toxin type-A (BoNT-A) is used to treat an increasingly wide range of indications. Although the toxin is generally considered healthy in controlled doses, its extensive use raises safety concerns. The main objective of this study was to present a guide on complications and safety measures when injecting botulinum toxin type-A for aesthetic purposes. This is a bibliographic review study. Searches were carried out in the PubMed, SciElo and LILACS databases to identify articles on the topic. Articles on complications and safety in the use of BoNT-A in the last 10 years (2012 to 2022) were considered eligible for the review. It was possible to observe that several factors must be taken into consideration by professionals working in the area of aesthetic health. Starting with the choice of products to be used, always looking for the best inputs from trusted brands and companies, the esthete must seek the best for his patients, carrying out a quality anamnesis, investigating clinical and psychological issues, thus getting to know the individual to be treated as thoroughly as possible. It is extremely important for professional success to have mastery of the techniques used, theoretical-practical knowledge of possible complications and, also, of the protocols that must be adopted in the different possibilities, resulting in safe and effective procedures for all parties involved.

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Section: Discussionmentioning

confidence: 98%

COMPLICATIONS AND SAFETY IN THE USE OF BOTULINUM TOXIN TYPE-A (BoNT-A) FOR AESTHETIC PURPOSES

Firmino

2023

JHS

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“…Los estudios sobre el uso de TB han sido alentadores y, en los últimos años, su aplicabilidad clínica se ha ampliado gradualmente, siendo ahora un posible método eficaz para el tratamiento anticicatrices (Yue et al, 2022). Al respecto, algunas revisiones sistemáticas (RS) y metaanálisis (MA) sugieren que existe un potencial beneficio de la inyección local de TB perioperatoria en la apariencia de la cicatriz y en la prevención de QU y CH (Prodromidou et al, 2015 ;Zhang D. Z. et al, 2016 ;Bi et al, 2019 ;Wang D et al, 2019 ;Yang & Li, 2019 ;Bartkowska et al, 2020 ;Chen et al, 2020 ;Guo et al, 2020 ;Song et al, 2020 ;Zhang W et al, 2020 ;Qiao et al, 2021 ;Xu et al, 2021 ;Fu et al, 2022 ;Ji et al, 2022 ;Wang W et al, 2022 ;Yue et al, 2022).…”

Section: Introductionunclassified

Inyección local de toxina botulínica para la prevención de cicatrices hipertróficas y queloides: un protocolo para una revisión panorámica

Silva Ruz,

Ramos Rojas,

Rada Giacaman

et al. 2024

ARS med

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INTRODUCCIÓN: Las cicatrices hipertróficas (CH) y queloides (QU) corresponden al resultado de una cicatrización patológica en la piel, que afectan la calidad de vida de quienes las presentan. Su tratamiento considera diversas intervenciones, muchas de las cuales son de alto costo y/o poco predecibles. Entre ellas, la toxina botulínica (TB) podría tener un efecto a nivel preventivo, aunque los resúmenes de evidencia presentan resultados disímiles. Por esto, proponemos sintetizar la evidencia proveniente de revisiones sistemáticas (RS) y metaanálisis (MA) de ensayos clínicos aleatorizados (ECA) sobre los efectos de la inyección local de TB en la prevención de CH y QU en pacientes que recibieron o recibirán un trauma quirúrgico en la piel. MÉTODOS Y ANÁLISIS: Revisión panorámica siguiendo una adaptación de la Declaración PRISMA-P. Ejecutaremos búsquedas sensibles en L·OVE (Living OVerview of Evidence), un repositorio y plataforma de clasificación que utiliza la base de datos Epistemonikos. Realizaremos la selección de estudios, extracción de datos y evaluación de la calidad de las RS por duplicado. Compararemos las revisiones a través de matrices de evidencia, incluyendo las RS que aborden una pregunta similar y los ECA incluidos en estas. Estimaremos la superposición entre revisiones mediante el método de área cubierta y área cubierta corregida. ÉTICA Y DIFUSIÓN: No se requiere aprobación ética. Esta revisión se publicará después de un proceso de revisión por pares. Sus resultados podrían ser utilizados por personal de salud para informar decisiones individuales y por tomadores de decisión de servicios de salud para guiar la asignación de recursos. PROSPERO ID: CRD42023431093

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The Impact of Botulinum Toxin Injection on the Outcomes of Breast Surgeries: A Systematic Review and Meta-Analysis

2023

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Background Breast surgeries aim to restore the natural appearance of the breasts with acceptable functional and cosmetic outcomes. However, these surgical procedures may be associated with considerable adverse events. The present systematic review and meta-analysis was designed to reveal the functional and aesthetic outcomes of botulinum toxins (BTX) injection in patients subjected to breast surgeries. Methods A literature review was performed up to 21 September 2022. All clinical studies included patients older than 18 years old and treated with BTX injection for breast surgeries were included. Results The present study included 12 articles, encompassing 496 patients. The average dosage of BTX injection ranged from 20 to 100 units. Injecting BTX significantly reduced the mean post-operative opioid analgesics usage (SMD −1.577; 95% −2.087, −1.067; P < 0.001) and the risk of severe animation deformity (RR 12.37; 95% 1.76, 86.66; P = 0.01). There was a statistically significant higher mean expansion volume per visit in the BTX injection group (SMD 1.166; 95% 0.313, 2.018; P = 0.007). There was no statistically significant impact of BTX injection on the risk of surgical site infection (RR 0.59; 95% 0.15, 2.34; P = 0.45) and seroma (RR 0.51; 95% 0.03, 10.15; P = 0.66). Conclusions The present study revealed the potential benefits of BTX injection in breast surgeries. This included reduced post-operative analgesics, as well as the risk of severe animation deformity. This was accomplished with increased expansion volume per visit and a similar risk of BTX injection-related complications. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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The Efficacy and Safety of Botulinum Toxin Type A Injections in Improving Facial Scars: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 38 publications

COMPLICATIONS AND SAFETY IN THE USE OF BOTULINUM TOXIN TYPE-A (BoNT-A) FOR AESTHETIC PURPOSES

COMPLICATIONS AND SAFETY IN THE USE OF BOTULINUM TOXIN TYPE-A (BoNT-A) FOR AESTHETIC PURPOSES

Inyección local de toxina botulínica para la prevención de cicatrices hipertróficas y queloides: un protocolo para una revisión panorámica

The Impact of Botulinum Toxin Injection on the Outcomes of Breast Surgeries: A Systematic Review and Meta-Analysis

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