The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial

Chan, Kaiyin; Lui, Louisa; Yu, Kaling; Lau, Kwongwai; Lai, Manchi; Lau, W.S.; Ng, Bacon Fung Leung; Zhong, Linda L. D.; Bian, Zhaoxiang

doi:10.1186/s13063-019-3972-5

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…Its underlying mechanism might associate with opioid peptides, adenosine, dopamine, cytokines, norepinephrine, and serotonin. [52][53][54] We were unable to objectively assess the efficacy of certain functional recovery standards because there were insufficient data to provide robust estimates of how LOS and health quality of life evolve. Adverse events of acupuncture were mild though inconsistently described.…”

Section: Summary Of Main Resultsmentioning

confidence: 99%

The effect of acupuncture on recovery after colorectal cancer resection: A systematic review meta-analysis of randomized controlled trials

Qi,

Shi,

Zhang

et al. 2023

Medicine

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Background: To evaluate the efficacy and safety of acupuncture by systematically reviewing the literature on colorectal cancer resection. Methods: Seven electronic databases were searched from inception to February 28, 2023. Randomized controlled trials on acupuncture in patients after CRC resection were included. Two reviewers independently selected relevant trials, extracted data, and assessed the risk of bias. A random-effects meta-analysis model was used to obtain summary effect estimates. The data were pooled and analyzed using RevMan 5.3. The heterogeneity of selected studies was evaluated by evaluating the I-squared (I 2) statistics. Results: Twenty-two studies with 1878 patients were included. Results of the meta-analysis showed there was a low level evidence that acupuncture may improve early postoperative symptoms, such as time to first flatus (n = 876, MD −0.77h, 95% CI −1.22 to −0.33 h, I 2 = 89%), time to first bowel movement (n = 671, MD −1.41h, 95% CI −2.20 to −0.63 h, I 2 = 95%), time to first defecation (n = 556, MD −1.03h, 95% CI −1.88 to −0.18 h, I 2 = 95%), and nausea/vomiting (n = 1488, RR 0.72, 95% CI 0.59–0.89, I 2 = 49%) compared with usual care and sham acupuncture. However, there were no statistically significant differences in postoperative pain (n = 1188, MD-0.21, 95% CI −0.59 to 0.17, I 2 = 74%). And there was no sufficient evidence of improving long-term functional outcomes. There was substantial heterogeneity across trials. The adverse events associated with acupuncture stimulation were minor in include studies. Conclusion subsections: There is currently low-level evidence supporting the use of acupuncture on postoperative symptoms for patients after colorectal cancer resection. More investigations should be established based on the STRICTA statement strictly.

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Section: Summary Of Main Resultsmentioning

confidence: 99%

The effect of acupuncture on recovery after colorectal cancer resection: A systematic review meta-analysis of randomized controlled trials

Qi,

Shi,

Zhang

et al. 2023

Medicine

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“…For example, EA treatment at the GV20 and ST36 acupoints improves model animal learning and memory abilities and protects against hippocampal injury, inhibits inflammatory factors, and regulates brain activity via antioxidative damage [ 25 , 26 ]. An increasing number of countries have endorsed the efficacy and safety of EA treatment [ 27 , 28 ]. These considerations led us to further explore the potential improving cognitive effects of EA treatment on CI in our SAMP8 mouse model.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway

et al. 2020

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Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the NLRP3/caspase-1 signaling pathway. Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. Ten male SAMR1 mice were assigned to the control group. Cognitive function was assessed through the Morris water maze test. Hippocampal morphology and cell death were observed by HE and TUNEL staining, respectively. The serum IL-1β, IL-6, IL-18, and TNF-α levels were measured by ELISA. Hippocampal NLRP3, ASC, caspase-1, GSDM-D, IL-1β, IL-18, Aβ, and tau proteins were detected by Western blotting. Key Findings. Cognitive function, hippocampal morphology, and TUNEL-positive cell counts were improved by both EA frequencies. The serum IL-1β, IL-6, IL-18, and TNF-α levels were decreased by EA treatment. However, 10 Hz EA reduced the number of TUNEL-positive cells in the CA1 region and serum IL-1β and IL-6 levels more effectively than 2 Hz EA. NLRP3/caspase-1 pathway-related proteins were significantly downregulated by EA, but 2 Hz EA did not effectively reduce ASC protein expression. Interestingly, both EA frequencies failed to reduce the expression of Aβ and tau proteins. Significance. The effects of 10 Hz EA at the GV20 and ST36 acupoints on the NLRP3/caspase-1 signaling pathway may be a mechanism by which this treatment relieves aging-related CI in mice.

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“…Moreover, this study will exclude those who have received acupuncture treatment in the last 3 months and can distinguish SA from MA. The same control with no skin penetration at acupoints was adopted and succeeded in masking patients with DPN [ 7 , 14 , 15 , 18 ]. Furthermore, all patients will be asked to guess which treatment they have received to test the patient-blinding effects at week 12.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture for diabetic peripheral neuropathy: study protocol for a randomized, placebo-controlled trial

Deng

Shu

et al. 2020

Trials

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Background Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes mellitus that has a considerable impact on quality of life, but there are few effective therapeutic strategies. The aim of this trial is to determine the efficacy and safety of manual acupuncture (MA) versus sham acupuncture (SA) for DPN. Methods/design This is a study protocol for a randomized, placebo-controlled clinical trial. A total of 118 patients with DPN will be recruited and randomly assigned in a 1:1 ratio to either the MA group or SA group. All patients will receive 24 sessions over 12 weeks. Participants will complete the trial by visiting the research center at month 6 for a follow-up assessment. The primary outcome is peroneal motor nerve conduction velocity (peroneal MNCV) at week 12 compared with baseline. Secondary outcomes include peroneal motor nerve action potential amplitude (peroneal MNAP) and latent period (peroneal MNLP), sural sensory nerve conduction velocity (sural SNCV), action potential amplitude (sural SNAP) and latent period (sural SNLP), fasting plasma glucose (FPG), 2-h postprandial blood glucose (2hPG), glycated hemoglobin (HbAlc) at week 12 compared with baseline, Michigan Neuropathy Screening Instrument (MNSI) score and Diabetes Specific Quality of Life scale (DSQL) at week 12 and month 6 compared with baseline. Safety will be assessed during the whole trial. Masking effectiveness will be assessed by patients. Discussion This trial may provide high-quality evidence for evaluating the efficacy and safety of MA treatment for DPN compared with SA treatment. Results of this study will be published in peer-reviewed journals. Trial registration Chinese Clinical Trials Registry ChiCTR1800020444. First registered on 29 December 2018, retrospectively registered, http://www.chictr.org.cn/showproj.aspx?Proj=31063.

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The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial

Cited by 11 publications

References 23 publications

The effect of acupuncture on recovery after colorectal cancer resection: A systematic review meta-analysis of randomized controlled trials

The effect of acupuncture on recovery after colorectal cancer resection: A systematic review meta-analysis of randomized controlled trials

Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway

Acupuncture for diabetic peripheral neuropathy: study protocol for a randomized, placebo-controlled trial

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