The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea

Letzel, Heinz; Mégard, Yves; Lamarca, Rosa; Raber, A; Fortea, J

doi:10.1016/j.ejogrb.2006.01.004

Cited by 25 publications

(19 citation statements)

References 9 publications

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“…Severe pain during dysmenorrhea is believed to be associated with early menarche, increased flow during menstruation and family history [14]. There are also studies indicating that stress and low socioeconomic status affect dysmenorrhea [2,4,15]. Dysmenorrhea is a condition that affects women's quality of life significantly and frequently prevents them from going to school or work [8].…”

Section: Introductionmentioning

confidence: 99%

Review of Frequency of Dysmenorrhea and Some Associated Factors and Evaluation of the Relationship between Dysmenorrhea and Sleep Quality in University Students

Şahin

Özdemir²,

Ünsal³

et al. 2014

Gynecol Obstet Invest

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Objective: To determine the frequency of dysmenorrhea in university students, review some associated factors and evaluate the relationship between dysmenorrhea and sleep quality. Material and Methods: The study group included 520 students. Survey forms prepared previously in line with the study objective were completed by the students under supervision. The severity of dysmenorrhea was rated with Visual Analogue Scale. Pittsburgh Sleep Quality Index was used to evaluate the sleep quality. The χ² test, Mann-Whitney U test and Kruskal-Wallis test were used for the analyses. Statistical significance level was accepted at p < 0.05. Results: Mean age of the students was 20.23 ± 1.59 years (range 17-25). Frequency of dysmenorrhea was determined to be 69.0% (n = 359). Frequency of dysmenorrhea was higher in smokers, those with menstrual irregularity, those who use drugs for menstrual regulation and those having a family history (p < 0.05 for each). The most frequent symptoms in those having dysmenorrhea history were weakness (59.6%), fatigue (58.5%) and breast tenderness (45.4%), respectively. Sleep quality was found to be poorer in the students having a history of dysmenorrhea (p < 0.05). Conclusions: Dysmenorrhea is an important health problem in young women. Dysmenorrhea affects the sleep quality negatively.

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Section: Introductionmentioning

confidence: 99%

Review of Frequency of Dysmenorrhea and Some Associated Factors and Evaluation of the Relationship between Dysmenorrhea and Sleep Quality in University Students

Şahin

Özdemir²,

Ünsal³

et al. 2014

Gynecol Obstet Invest

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“…Another in osteoarthritis claimed equivalence of aceclofenac 200 mg daily with diclofenac 150 mg daily (Pareek 2006). Aceclofenac 100 mg daily was superior to placebo and equivalent to naproxen 500 mg in dysmenorrhoea (Letzel 2006).…”

Section: Discussionmentioning

confidence: 87%

Single dose oral aceclofenac for postoperative pain in adults

Moore¹,

Derry²,

McQuay³

2009

Cochrane Database of Systematic Reviews

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Background-Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy and safety of oral aceclofenac in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.

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“…Обезболивающая активность 100 мг ацек-лофенака по продолжительности действия превышает тако-вую после приема 650 мг парацетамола. Кроме того, имеются данные об использовании его для купирования острых боле-вых синдромов при стоматологических и гинекологических заболеваниях [12,13]. Исследования показали, что ацеклофе-нак обладает достаточно выраженным обезболивающим эф-фектом, сопоставимым с таковым основных НПВП -дикло-фенака, кетопрофена, напроксена, пироксикама, индомета-цина.…”

Section: Discussionunclassified

“…[18], изучившие данные о кровотечениях у 2777 больных (5532 па-циента составили контрольную группу), поступивших в кли-ники Испании в 2002-2004 гг., выявили, что относительный риск (ОР) данного осложнения при использовании ацекло-фенака составил 2,6 (1,6). ОР при использовании дикло-фенака был 3,1 (2,3-4,2), ибупрофена -4,1 (3,1-5,3), напро-ксена -7,3 (4,7-11,4), кетопрофена -8,6 (2,5-29,2), индоме-тацина -9,0 (3,9-20,7), пироксикама -12,6 (7,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)3) [18].…”

Section: Discussionunclassified

“…Мутация CIAS1-гена обнаруживается не у всех больных: среди пациентов с CAPS -только у 60%, с MWS и NOMID -у 50-70%, что указывает на генетическую гетерогенность этих трех синдромов [3,9]. За первые 2 года после создания международного ре-гистра АВС EUROFEVER в него включено 180 пациен-тов с CAPS [10,11], хотя в реальной практике их значи-тельно больше, при этом описано более 100 пациентов с CINCA/NOMID-синдромом [12]. Сведения о распро-страненности этих синдромов в мире вариабельны и за-частую недостоверны из-за недостаточной информиро-ванности врачей об этом заболевании и вследствие этого гипо-или гипердиагностики.…”

Section: л и т е р а т у р аunclassified

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