The efficacy and safety of a novel posterior scleral reinforcement device in rabbits

Yuan, Yongguang; Zong, Yao; Zheng, Qishan; Garrett, Qian; Qian, Xiaohong; Li, Yujie; Shao, Wanwen; Gao, Qianying

doi:10.1016/j.msec.2015.12.046

Cited by 10 publications

(9 citation statements)

References 28 publications

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“…The ends of the strip are then crossed over the medial rectus muscle and sutured to the sclera on the medial aspect of the superior and inferior recti (Thompson, 1990). One source of controversy stems from difficulty in obtaining and storing donor tissue, and this is driving current efforts to develop biocompatible artificial materials and devices (Yuan et al, 2016). Meanwhile, established and emerging adjunct procedures such as patching therapy (Shen et al, 2015b) and collagen crosslinking (Xue et al, 2018) (see s5.2) are being combined with surgical reinforcement in an effort to improve efficacy and safety.…”

Section: Primary Scleral Surgeriesmentioning

confidence: 99%

Scleral structure and biomechanics

Boote

Sigal

Grytz

et al. 2020

Progress in Retinal and Eye Research

208

161

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Section: Primary Scleral Surgeriesmentioning

confidence: 99%

Scleral structure and biomechanics

Boote

Sigal

Grytz

et al. 2020

Progress in Retinal and Eye Research

208

161

View full text Add to dashboard Cite

show abstract

“…PSR has been considered an effective and safe surgical method for stabilization of the axial elongation and prevention of high myopic complications ( 5 , 12 ). The mechanism by which PSR may slow down the elongation of the eyeball was presumably due to the direct mechanical force of the reinforcement band and the scleral remodeling and improvement of microcirculation within the macula ( 13 , 14 ). However, whether or not PSR could change the choroidal thickness (CT) and choroidal blood flow is still under debate due to lack of satisfactory quantitative methods ( 5 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Macular Choroidal Thickness and Blood Flow Change by Optical Coherence Tomography Angiography After Posterior Scleral Reinforcement

Zhang

Wei

et al. 2021

Front. Med.

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Purpose: This work aimed to study the effect of posterior scleral reinforcement (PSR) on choroidal thickness (CT) and blood flow.Methods: This study included 25 eyes of 24 patients with high myopia ( ≤ -6.0 dioptres or axial length ≥ 26.0 mm) who underwent PSR surgery. All patients completed the 1-month follow-up visit. Myopic macular degeneration (MMD) was graded according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification based on color fundus photographs. Swept-source optical coherence tomography angiography (SSOCTA) was performed to investigate CT, choroidal perfusion area (CPA), and choriocapillaris perfusion area (CCPA) change following PSR surgery.Results: The distribution of MMD categories was 9 (36.0%) in category 1, 10 (40.0%) in category 2, and 6 (24.0%) in category 3 or 4. MMD severity was strongly correlated with CT (all P < 0.01) and CPA (all P < 0.04). Postoperative CT at each sector increased significantly at 1 week's follow-up, compared to preoperative measures (all P < 0.05). Postoperative CPA at subfoveal, superior, inferior, and nasal sectors also increased significantly 1 week after PSR surgery (all P < 0.05). Moreover, the increased CT, CPA, and CCPA remain after PSR surgery at 1 month's follow-up, but the difference was not statistically significant.Conclusions: We demonstrated that the CT and choroidal blood flow increased significantly in patients with high myopia who underwent PSR surgery in a short period of time. In addition, the CT and CPA were independently associated with MMD. However, whether the transient improvement of the choroidal circulation could prevent long-term progression of high myopia warrants further study in the future.

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“…High myopia, especially pathological myopia, is associated with an excessive axial elongation of eyeball, which probably caused by scleral biomechanical weakness and thinning [ 3 ]. Until now, many therapeutic attempts to resist myopic progression have been developed, including various posterior scleral reinforcement surgery [ 4 – 6 ]. Nevertheless, the efficient of these methods is controversial, and no evidence shows that the internal structure of the weakened sclera can be regenerated by these means.…”

Section: Introductionmentioning

confidence: 99%

“…Some literature also investigated changes of intraocular pressure (IOP) on scleral reinforced eyes, since it was known that IOP is closely associated with myopia [ 16 – 17 ]. But the results were still controversial in different scleral reinforcement methods [ 4 , 18 , 19 ]. Studies from our research group investigated electroretinography (ERG) changes on non-primate animal models and indicated that the dark-adapted ERG amplitudes were statistically reduced 1 week, 1 month and 3 months postoperatively [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Study of retina and choroid biological parameters of rhesus monkeys eyes on scleral collagen cross-linking by riboflavin and ultraviolet A

et al. 2018

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To evaluate ocular fundus biological changes after scleral collagen cross-linking (CXL) with riboflavin/ ultraviolet A (UVA) on rhesus monkeys in vivo by analyzing retina and choroid biological parameters. Six 3-year-old male rhesus monkeys (12 eyes) were observed in this study, with scleral CXL procedures applied on superior temporal equatorial sclera on random eyes of all rhesus. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) examination were performed before and 1 week, 1 month, 3 months and 6 months after CXL. The thickness of retina and choroid and the flow density of retinal superficial vascular networks were analyzed respectively in different regions after CXL. As for retina thickness and flow density of retinal superficial vascular networks, no statistical difference was noted between CXL eyes and control eyes at 1 day, 1week, 1 month, 3 months and 6 months (P>0.05). Among choroid parameters, the choroidal thickness in 1500μm temporal to the fovea center of CXL eyes revealed a significant reduction in 1 week postoperatively (P<0.05), but it subsequently increased from 1 month postoperatively, and no statistical difference was found between two groups in the following periods (P>0.05). The choroidal thickness nearby crosslinked region may change temporarily following scleral CXL, and it might recover gradually after 1 month postoperatively. The vascular flow density and thickness of retina were not affected by scleral CXL. Further study should be performed to evaluate the potential adverse effects at the direct vicinity of the application site and the long-term effect of scleral CXL in clinical application.

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The efficacy and safety of a novel posterior scleral reinforcement device in rabbits

Abstract: In vivo study, effectively and safely, the novel PSR device can inhibit rabbits' axial length elongation during postoperative 1 year. This study demonstrates that this novel PSR could be a potential treatment approach for myopia.

Cited by 10 publications

References 28 publications

Scleral structure and biomechanics

Scleral structure and biomechanics

Investigation of Macular Choroidal Thickness and Blood Flow Change by Optical Coherence Tomography Angiography After Posterior Scleral Reinforcement

Study of retina and choroid biological parameters of rhesus monkeys eyes on scleral collagen cross-linking by riboflavin and ultraviolet A

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