The efficacy and safety of aminolevulinic acid 20% topical solution activated by pulsed dye laser and blue light for the treatment of facial cutaneous squamous cell carcinoma in situ

Nestor, Mark S.; Han, Haowei; Yousefian, Faraz; Smythe, Ciaran

doi:10.25251/skin.7.supp.183

Cited by 2 publications

(1 citation statement)

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“…14,15 Hypo-and hyperpigmentation are reported in 5% of patients who receive topical PDT; scarring occurs in less than 1%. 16,17 Despite the excellent cosmesis, the recommendation for BCC treatment with topical PDT is limited to sBCC and thin (<2 mm) nBCCs, due to lower clearance rates in thick nodular or infiltrative BCCs. 2 By comparison, recurrence rates in topical PDT for BCC treatment after a year are 19−27%, while recurrence rates with standard surgical excision of BCCs are between 2 and 10%.…”

Section: Discussionmentioning

confidence: 99%

Jet‐injection assisted photodynamic therapy for superficial and nodular basal cell carcinoma: A pilot study

Lavin,

Erlendsson,

Aleissa

et al. 2024

Lasers Surg Med

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BackgroundPhotodynamic therapy (PDT) with topical δ‐Aminolevulinic acid (ALA) has efficacy in treating basal cell carcinoma (BCC) but is limited by incomplete penetration of ALA into the deeper dermis. This prospective open‐label pilot trial investigated the safety and efficacy of photosensitizer jet injection for PDT (JI‐PDT) for BCC treatment. It was performed with 15 patients (n = 15) with histologically confirmed, untreated, low‐risk nodular BCCs at a single institution.MethodsFor the intervention, JI‐PDT patients (n = 11) received two sessions of jet‐injected ALA with PDT separated by four to 6 weeks. To further understand treatment technique, another group of patients (n = 4) received jet‐injected ALA followed by tumor excision and fluorescence microscopy (JI‐E). Treatment tolerability was assessed by local skin responses (LSR) score at five distinct time intervals. Fluorescence microscopy assessed protoporphyrin IX penetration depth and biodistribution within the tumor. At the primary endpoint, tumor clearance was evaluated via visual inspection, dermoscopy and reflectance confocal microscopy. Postinjection and postillumination pain levels, and patient satisfaction, were scored on a 0−10 scale.ResultsFifteen participants with mean age of 58.3, who were 15/15 White, non‐Hispanic enrolled. The median composite LSR score immediately after JI‐PDT was 5 (interquartile range [IQR] = 3) which decreased to 0.5 (IQR = 1) at primary endpoint (p < 0.01). Immunofluorescence of excised BCC tumors with jet‐injected ALA showed photosensitizer penetration into papillary and reticular dermis. Of the 13 JI‐PDT tumors, 11 had tumor clearance confirmed, 1 recurred, and 1 was lost to follow‐up. 1/11 patients experienced a serious adverse event of cellulitis. 70% of patients had local scarring at 3 months. Patients reported an average pain level of 5.6 (standard deviation [SD] = 2.3) during jet injection and 3.7 (SD = 1.8) during light illumination.ConclusionsJet injection of ALA for PDT treatment of nodular low‐risk BCC is tolerable and feasible and may represent a novel modality to improve PDT.

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Section: Discussionmentioning

confidence: 99%

Jet‐injection assisted photodynamic therapy for superficial and nodular basal cell carcinoma: A pilot study

Lavin,

Erlendsson,

Aleissa

et al. 2024

Lasers Surg Med

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Analysis of temperature behavior in biological tissue in photothermal therapy according to laser irradiation angle

Kim,

Kim

2023

Bioengineered

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The type of death of biological tissue varies with temperature and is broadly classified as apoptosis and necrosis. A new treatment called photothermal therapy is being studied on this basis. Photothermal therapy is a treatment technique based on photothermal effects and has the advantage of not requiring incisions and, therefore, no bleeding. In this study, a numerical analysis of photothermal therapy for squamous cell carcinoma was performed. Photothermal agents used were gold nanoparticles, and the photothermal therapy effect was confirmed by changing the angle of the laser irradiating the tumor tissue. The effectiveness of photothermal therapy was quantitatively assessed on the basis of three apoptotic variables. Further, the volume fraction of gold nanoparticles in the tumor tissue and laser intensity with optimal therapeutic effect for different laser irradiation angles were studied. Thus, the findings of this study can aid the practical implementation of photothermal therapy in the future.

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The efficacy and safety of aminolevulinic acid 20% topical solution activated by pulsed dye laser and blue light for the treatment of facial cutaneous squamous cell carcinoma in situ

Cited by 2 publications

References 0 publications

Jet‐injection assisted photodynamic therapy for superficial and nodular basal cell carcinoma: A pilot study

Jet‐injection assisted photodynamic therapy for superficial and nodular basal cell carcinoma: A pilot study

Analysis of temperature behavior in biological tissue in photothermal therapy according to laser irradiation angle

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