The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial

Wang, Lei; Zhang, Jinling; Chen, Guo; He, Jia-Kai; Zhang, Shuai; Wang, Yu; Yu-hong, Zhao; Li, Liang; Wang, Junying; Hou, Liwei; Li, Shaoyuan; Wang, Yifei; Hao, Lixiao; Zhao, Yufeng; Wu, Mozheng; Fang, Jiliang; Rong, Peijing

doi:10.1016/j.brs.2022.09.003

Cited by 47 publications

(27 citation statements)

References 37 publications

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“…Epidemiological studies show that the prevalence of MCI continues to increase, and with the worsening of population aging ( Chen et al, 2022 ), MCI will become a major risk factor threatening the health of the elderly. Short-term conversion rate from MCI to dementia is between 20 and 40%, but long-term in 5–10 years ranges from 60 to 100% ( Wang et al, 2022 ). In addition, MCI is also a common functional disorder in PD, stroke and other diseases, the main manifestations of patients with memory, attention, executive ability, speech and logical thinking ( Tatemichi et al, 1994 ; Li et al, 2019 ), seriously affect the prognosis of patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of movement training based on rhythmic auditory stimulation in cognitive impairment: a meta-analysis of randomized controlled clinical trial

Wang,

Wen,

Chen

et al. 2024

Front. Neurosci.

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ObjectiveAccording to the World Alzheimer’s Disease Report in 2015,there were 9.9 million new cases of dementia in the world every year. At present, the number of patients suffering from dementia in China has exceeded 8 million, and it may exceed 26 million by 2040.Mild cognitive impairment (MCI) refers to the pathological state of pre-dementia with the manifestation of the progressive decline of memory or other cognitive functions but without decline of activities of daily life. It is particularly important to prevent or prolong the development of MCI into dementia. Research showing effects of rhythmic auditory stimulation based-movement training(RASMT) interventions on cognitive function is also emerging. Therefore, the present meta-analysis briefly summarize findings regarding the impacts of RASMT programs on cognitive impairment.MethodsData from Pubmed, Embase, and Cochrane Library were utilized. The impact of RASMT on cognitive functions was evaluated using indicators such as overall cognitive status, memory, attention, and executive functions. The REVMAN5.3 software was employed to analyze bias risks integrated into the study and the meta-analysis results for each indicator.ResultsA total of 1,596 studies were retrieved, of which 1,385 non-randomized controlled studies and 48 repetitive studies were excluded. After reviewing titles and abstracts of the remaining 163 articles, 133 irrelevant studies were excluded, 30 studies were downloaded and read the full text. Among 30 articles, 18 articles that did not meet the inclusion criteria were excluded, the other 12 studies were included in this meta-analysis. Utilizing the Cochrane Collaborative Network Bias Risk Assessment Scale, it was found that 11 studies explained the method of random sequence generation, nine studies did not describe allocation concealment, four were single-blinded to all researchers, and eight reported single-blinding in the evaluation of experimental results. In the meta-analysis, the main outcomes showed statistically significant differences in overall cognitive status [MD = 1.19, 95%CI (0.09, 2.29), (p < 0.05)], attention [MD = −1.86, 95%CI (−3.53, −0.19), (p < 0.05)], memory [MD = 0.71, 95%CI (0.33, 1.09), (p < 0.01)], and executive function [MD = −0.23, 95% CI (−0.44, −0.02), (p < 0.05)]. Secondary outcomes indicated no statistically significant differences in verbal fluency [MD = −0.51, 95%CI (−1.30, 0.27), (p = 0.20)], while depression [MD = −0.29, 95% CI (−0.42, −0.16), (p < 0.01)] and anxiety [MD = 0.19, 95% CI (0.06, 0.32), (p < 0.01)] exhibited statistically significant differences. The GRADEpro GDT online tool assessed the quality of evidence for the outcome measures, revealing one low-quality outcome, two moderate-quality outcomes, and one high-quality outcome in this review.ConclusionThis study shows that RASMT can improve the general cognitive status, memory, attention and executive function of patients with cognitive impairment. The quality of evidence revealed that MMSE was low, attention and memory were moderate, and executive function was high. The RAMST program (type of exercise: play percussion instruments; time of exercise: 30–60 min; frequency of exercise: 2–3 times/week; duration of exercise: more than 12 weeks) was proved to be more effective in improving cognitive function. However, the sample size is relatively insufficient, the future needs further study.Systematic review registrationPROSPERO, identifier: CRD42023483561.

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Section: Discussionmentioning

confidence: 99%

Effects of movement training based on rhythmic auditory stimulation in cognitive impairment: a meta-analysis of randomized controlled clinical trial

Wang,

Wen,

Chen

et al. 2024

Front. Neurosci.

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“…It is noteworthy to mention that 70% of AD patients showed no further cognitive function impairment after application of iVNS to 17 AD patients for 6 months. 97 Potential of VNS in altering multiple AD progression has been demonstrated in the previous study where VNS provided antiinflammatory signaling, increased metabolic support of neuronal function by dint of astrocytes, modified accumulation of Aβ pathology, and supported neuronal plasticity. 98 Activation of the locus coeruleus (LC) by VNS results in catecholamine release in the neocortex and hippocampus which ultimately causes reduction of inflammatory signals and augmentation of synaptic plasticity.…”

Section: Alternative Treatment Optionsmentioning

confidence: 91%

The Neuropathological Impacts of COVID-19: Challenges and Alternative Treatment Options for Alzheimer’s Like Brain Changes on Severely SARS-CoV-2 Infected Patients

Rahman,

Akter,

Neelotpol

et al. 2023

Am J Alzheimers Dis Other Demen

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Recently, some researchers claimed neuropathological changes lead to Alzheimer’s-like brains after severe infection of SARS-CoV-2. Several mechanisms have been postulated on how SARS-CoV-2 neurological damage leads to Alzheimer's disease (AD) development. Neurobiochemical changes during infection may significantly induce Alzheimer's disease in severely COVID-19 infected people. The immune system is also compromised while infected by this novel coronavirus. However, recent studies are insufficient to conclude the relationship between Alzheimer's disease and COVID-19. This review demonstrates the possible pathways of neuropathological changes induced by the SARS-CoV-2 virus in AD patients or leading to AD in COVID-19 patients. Therefore, this study delineates the challenges for COVID-19 infected AD patients and the mechanism of actions of natural compounds and alternative treatments to overcome those. Furthermore, animal studies and a large cohort of COVID-19 survivors who showed neuroinflammation and neurological changes may augment the research to discover the relationship between Alzheimer's disease and COVID-19.

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“…In combination with limb rehabilitation training, taVNS may improve coordinated activity of the muscle groups of upper arms by reducing post‐stroke spasticity and increasing motor control 140 . Studies also indicated that taVNS can improve post‐stroke insomnia and cognitive performance 146,147 . Animal experiments had demonstrated that taVNS is an effective treatment strategy for patients and model rats with dysphagia after acute stroke 144,148 .…”

Section: Treatment Strategiesmentioning

confidence: 99%

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Kang,

Shi,

Liu

et al. 2024

CNS Neurosci Ther

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AimsAutonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical practice and research on autonomic dysfunction in ICH patients.DiscussionWe summarize the autonomic dysfunction in ICH from the aspects of potential mechanisms, clinical significance, assessment, and treatment strategies. The CAN structures mainly include insular cortex, anterior cingulate cortex, amygdala, hypothalamus, nucleus of the solitary tract, ventrolateral medulla, dorsal motor nucleus of the vagus, nucleus ambiguus, parabrachial nucleus, and periaqueductal gray. Autonomic dysfunction after ICH is closely associated with neurological functional outcomes, cardiac complications, blood pressure fluctuation, immunosuppression and infection, thermoregulatory dysfunction, hyperglycemia, digestive dysfunction, and urogenital disturbances. Heart rate variability, baroreflex sensitivity, skin sympathetic nerve activity, sympathetic skin response, and plasma catecholamine concentration can be used to assess the autonomic functional activities after ICH. Risk stratification of patients according to autonomic functional activities, and development of intervention approaches based on the restoration of sympathetic‐parasympathetic balance, would potentially improve clinical outcomes in ICH patients.ConclusionThe review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.

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The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial

Cited by 47 publications

References 37 publications

Effects of movement training based on rhythmic auditory stimulation in cognitive impairment: a meta-analysis of randomized controlled clinical trial

Effects of movement training based on rhythmic auditory stimulation in cognitive impairment: a meta-analysis of randomized controlled clinical trial

The Neuropathological Impacts of COVID-19: Challenges and Alternative Treatment Options for Alzheimer’s Like Brain Changes on Severely SARS-CoV-2 Infected Patients

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

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