The efficacy and safety of Chinese herbal medicines

Opara, Elizabeth I.

doi:10.1079/bjn20031060

Cited by 14 publications

(6 citation statements)

References 42 publications

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“…Relatively high concentrations of heavy metals such as lead and cadmium in Chinese herbal plants have been reported (Wong, Tan, & Wee, 1993). Furthermore, several cases of heavy metal poisoning associated with the consumption of CHM have been reported in the literature (Chan, Yeh, Billmeier Jr., Evans, & Chan, 1977;Ernst, 2002;Opara, 2004).…”

Section: Introductionmentioning

confidence: 98%

Accurate determination of lead in Chinese herbs using isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS)

Lam¹,

Chan²,

Yip³

et al. 2010

Food Chemistry

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Section: Introductionmentioning

confidence: 98%

Accurate determination of lead in Chinese herbs using isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS)

Lam¹,

Chan²,

Yip³

et al. 2010

Food Chemistry

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“…The safety of CHMs is a key factor for their clinical application ( Opara, 2004 ). However, CHM ingredients are complex that exert effects by targeting multiple factors and pathways, and the interaction between ingredients is not clear, resulting in difficulty in determining the toxicity of CHM substances.…”

Section: Perspectives and Challengesmentioning

confidence: 99%

Chinese Herbal Medicine for Primary Liver Cancer Therapy: Perspectives and Challenges

Xiao

Zhu

et al. 2022

Front. Pharmacol.

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Primary liver cancer (PLC) is one of the most common solid malignancies. However, PLC drug development has been slow, and first-line treatments are still needed; thus, studies exploring and developing alternative strategies for effective PLC treatment are urgently needed. Chinese herbal medicine (CHM) has long been applied in the clinic due to its advantages of low toxicity and targeting of multiple factors and pathways, and it has great potential for the development of novel natural drugs against PLC.Purpose: This review aims to provide an update on the pharmacological mechanisms of Chinese patent medicines (CPMs) and the latest CHM-derived compounds for the treatment of PLC and relevant clinical evaluations.Materials and Methods: A systematic search of English literature databases, Chinese literature, the Clinical Trials Registry Platform, and the Chinese Clinical Trial Registry for studies of CHMs for PLC treatment was performed.Results: In this review, we summarize the clinical trials and mechanisms of CPMs for PLC treatment that have entered the clinic with the approval of the Chinese medicine regulatory authority. These CPMs included Huaier granules, Ganfule granules, Fufang Banmao capsules, Jinlong capsules, Brucea javanica oil emulsions, and compound kushen injections. We also summarize the latest in vivo, in vitro, and clinical studies of CHM-derived compounds against PLC: icaritin and ginsenoside Rg3. Dilemmas facing the development of CHMs, such as drug toxicity and low oral availability, and future developments are also discussed.Conclusion: This review provides a deeper the understanding of CHMs as PLC treatments and provides ideas for the development of new natural drugs against PLC.

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“…This assumption comes in harmony with that of Galeone et al (2006) who reported that onion is said to contain antioxidants. Onion may have stimulated pancreatic β-cells which may enhance their production of insulin (Opara, 2004), and, more importantly, the possibility that onion may enhance cellular response to insulin (making target cells more responsive to insulin). Mi-Ae et al,(2009) reported that blood glucose levels of rats supplemented with onion (powder 7% w/w) were lower than those of rats fed control diet in the diabetic rats.…”

Section: Blood Serum Metabolitesmentioning

confidence: 99%

INFLUENCE OF USING ROCKET SEED (Eruca sative) OIL AND ONION SEED (Allium cepa) OIL ON PRODUCTIVE AND PHYSIOLOGICAL PERFORMANCE OF GROWING RABBITS UNDER HOT CLIMATE CONDITION

Ezzat¹,

Hamed²

2012

Journal of Productivity and Development

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A completely random experiment was conducted to evaluate rocket and onion seed oils or their mixture under climate summer conditions on growth performance, carcass traits, rectal temperature, respiration rate, immunity (antibody titer against SRBC'S), blood biochemistry, digestibility coefficients, and economical efficiency of growing rabbits, from July to September, 2009 .The averages of daily ambient temperature, relative humidity and temperature humidity index (THl) inside the building were 30.27 ±0. 68°C, 75.95±2.88% and 29.36, respectively. A total of 96 NZW rabbits, weaned at 6 weeks of age with an average initial body weight, 623.00 ± 3.09,g were randomly distributed to four experimental treatments (24 rabbits/ each) then divided into 3 replicates of eight rabbits each. Rabbits were fed the basal diet either unsupplemented (control) or supplemented with 1g rocket seed oil/Kg diet, or 1g onion seed oil/ Kg diet and their combination throughout the whole experimental period which lasted for 12 weeks. The experimental basal diet was isonitrogenous (CP=17 %) and isocaloric (2500 Kcal/Kg DE).Results obtained showed that percentages of total unsaturated fatty acids, especially polyunsaturated fatty acid (linoleic) in onion oil were higher than in rocket oil. The percentage of fatty acid Erucic was higher in rocket oil than those in onion oil. Under the high ambient temperatures final body weight and carcass traits of growing rabbits were significantly (P<0.05) increased and feed conversion values were improved with dietary supplementation with either rocket oil or onion recorded the highest (P<0.05) net return, best economical efficiency and performance index followed by those fed rocket oil plus onion oil and onion oil treatments as compared with the control group.In conclusion, supplementation of rocket and onion seed oils in growing rabbit diets enhanced growth performance carcass weight and digestibility coefficient of CP, EE and elevated the immunity as well as reduced rectal temperature and respiration rate when growing rabbits were subjected to heat stress.

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The efficacy and safety of Chinese herbal medicines

Cited by 14 publications

References 42 publications

Accurate determination of lead in Chinese herbs using isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS)

Accurate determination of lead in Chinese herbs using isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS)

Chinese Herbal Medicine for Primary Liver Cancer Therapy: Perspectives and Challenges

INFLUENCE OF USING ROCKET SEED (Eruca sative) OIL AND ONION SEED (Allium cepa) OIL ON PRODUCTIVE AND PHYSIOLOGICAL PERFORMANCE OF GROWING RABBITS UNDER HOT CLIMATE CONDITION

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