The efficacy and safety of Xihuang Pill/capsule in adjuvant treatment of breast cancer: A systematic review and meta-analysis of 26 randomized controlled trials

Ge, Anqi; Yang, Kailin; Deng, Xianguang; Da, Zhao; Ge, Jinwen; Liu, Lifang

doi:10.1016/j.jep.2022.115357

Cited by 14 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhang et al found that berberine can alter the functions and metabolites of the gut microbiota. And Zhao et al used berberine to treat a mouse model with acute graftversus-host disease (aGVHD); their results suggest that the berberine could remodel gut microbiota and prevent colonic barrier impairment (Zhao et al, 2022). Other scholars also found that berberine increased the abundance of beneficial bacteria that can produce SCFAs, and the SCFAs can directly alleviate the accumulation of uric acid (Shan et al, 2022).…”

Section: Alkaloidmentioning

confidence: 99%

“…(Zhang et al, 2021b). It has been widely used in the treatment of a variety of malignant tumors in clinics in China, including breast cancer, lung cancer, gastric cancer, and other malignant tumors (Wang et al, 2020a;Wang et al, 2021a;Ge et al, 2022). In mice with Lewis lung cancer, Cao et al investigated the anti-lung cancer impact of XHW coupled with anlotinib (LLC).…”

Section: Compound Formulation Of Tcmmentioning

confidence: 99%

“…Oncol/Hematol 145, 102841. doi: 10.1016/j.critrevonc. 2019.102841 Ni, L., Kong, L., Tang, Y., Nie, Y., Wang, X., Yang, X., et al (2022). The experimental exploration of TCM theory "Treating the same disease with different approaches" on an ulcerative colitis model.…”

Section: Author Contributionsmentioning

confidence: 99%

See 2 more Smart Citations

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Wang

Hou

Meng

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Non-small cell lung cancer (NSCLC) is one of the most serious diseases affecting human health today, and current research is focusing on gut flora. There is a correlation between intestinal flora imbalance and lung cancer, but the specific mechanism is not clear. Based on the “lung and large intestine being interior-exteriorly related” and the “lung-intestinal axis” theory. Here, based on the theoretical comparisons of Chinese and western medicine, we summarized the regulation of intestinal flora in NSCLC by active ingredients of traditional Chinese medicine and Chinese herbal compounds and their intervention effects, which is conducive to providing new strategies and ideas for clinical prevention and treatment of NSCLC.

show abstract

Section: Alkaloidmentioning

confidence: 99%

Section: Compound Formulation Of Tcmmentioning

confidence: 99%

See 1 more Smart Citation

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Wang

Hou

Meng

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Xihuang Pill (XHP), a natural compound prescription of Chinese herbal medicine, contains Niuhuang, Shexiang, Ruxiang and Moyao. As a natural product for the treatment of BrCa with advantages of natural sources, exact e cacy, and less side reactions [7][8]. The mechanism of XHP effect is likely related to the regulation of IFNG, EGFR, TP53 and mTOR protein gene expressions, et al [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Xihuang Pill regulates Ferroptosis-Related Genes, contributing to improved prognosis of Breast Cancer

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

The natural compound Xihuang Pill (XHP) has an anti-cancer effect and was effective for breast cancer (BrCa) prevention and treatment. However, the mechanisms underlying this effect remain poorly characterized. Here, we searched the ferroptosis-related genes (FRGs) regulated by XHP using the HERB and FerrDb databases, and extracted the FRGs' data on expression and pertinent clinical data by way of the TCGA dataset. A single-factor Cox regression analysis was used to confirm FRGs associated with prognosis, and LASSO Cox regression analysis was used for prognostic model building. We then constructed a prognostic model and assessed it based on Kaplan-Meier survival curves and ROC curves. Next, we applied GO, KEGG, and ssGSEA analyses to further investigate FRGs' functions and potential mechanisms. We discovered that eight FRGs from the XHP targets were associated with a higher likelihood of survival. The prognostic model formed by eight genes also possessed good prognostic ability, and the risk score could be a separate risk factor for the BrCa prognosis. The GO, KEGG, and ssGSEA analyses showed risk score-related genes were associated with immune-related activities. Molecular docking showed that quercetin and beta-sitosterol as XHP's active ingredients are effective and promising agents for the treatment of BrCa. Our results provided insights into the underlying molecular mechanisms by which XHP improves BrCa patient prognosis; quercetin and beta-sitosterol may provide a new road for anti-BrCa natural products.

show abstract

“…), and Myrrha (from Commiphora myrrha Engl. ) [ 10 ], which typically represents Huoxuehuayu therapy, one of the TCM therapies to promote blood circulation and remove blood stasis. In the previous study [ 11 ], we demonstrated that Huoxuehuayu therapy showed promise in cancer treatment, improving quality of life, addressing cancer-related symptoms, and reducing toxicity in a secure way.…”

Section: Introductionmentioning

confidence: 99%

The prospect of Xihuang pill in the treatment of cancers

Chen¹,

Li²,

Yang³

et al. 2023

Heliyon

View full text Add to dashboard Cite

The efficacy and safety of Xihuang Pill/capsule in adjuvant treatment of breast cancer: A systematic review and meta-analysis of 26 randomized controlled trials

Cited by 14 publications

References 17 publications

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Xihuang Pill regulates Ferroptosis-Related Genes, contributing to improved prognosis of Breast Cancer

The prospect of Xihuang pill in the treatment of cancers

Contact Info

Product

Resources

About