The Efficacy and Safety of Tranexamic Acid Treatment in Orthopaedic Trauma Surgery

Perskin, Cody R.; Littlefield, Connor P.; Wang, Charles; Umeh, Uchenna O.; Egol, Kenneth A

doi:10.2106/jbjs.rvw.20.00292

Cited by 2 publications

(1 citation statement)

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“…First introduced in the 1960s and gaining widespread use in gynecology, TXA is a synthetic analog of the amino acid lysine. Tranexamic acid inhibits plasminogen activation to plasmin through competitive inhibition of the 5 lysine-binding site on the surface of plasminogen [ 39 , 63 ]. It also acts as a competitive inhibitor of tissue plasminogen activator, leading to inhibition of fibrinolysis.…”

Section: Tranexamic Acidmentioning

confidence: 99%

The Efficacy and Safety of Tranexamic Acid in Total Hip and Knee Arthroplasty: A Literature Review

Borsinger,

Chandi,

Puri

et al. 2023

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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Historically, total hip arthroplasty (THA) and total knee arthroplasty (TKA) have been associated with significant perioperative blood loss and a relatively high rate of allogeneic blood transfusions. However, in recent years, tranexamic acid (TXA), a competitive inhibitor of tissue plasminogen activator, inhibiting fibrinolysis of existing thrombi, has substantially decreased the need for blood transfusion in THA and TKA. Various administration strategies have been studied, but there remains a lack of consensus on an optimal route and dosing regimen, with intravenous and topical regimens being widely used. A growing body of literature has demonstrated the safety and efficacy of TXA in primary and revision THA and TKA to reduce blood loss, allogeneic transfusions, and complications; it is associated with lowered lengths of stay, costs, and readmission rates.

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Section: Tranexamic Acidmentioning

confidence: 99%