The efficacy and safety of tranexamic acid in foot and ankle surgery: A systematic review and meta-analysis of comparative clinical studies

Letter Regarding: Tranexamic Acid Utilization in Foot and Ankle Surgery: A Meta-analysis

“…It is our pleasure to thank the team of Dr Blankenhorn for performing the study titled "Tranexamic Acid Utilization in Foot and Ankle Surgery: A Meta-analysis." 6 As a result of a similar analysis we conducted recently, 5 we have some concerns about the results reported and would like to share our opinions.…”

“…It remains to be determined whether TXA plays a role in the long-term follow-up. In the end, we invite you to read and provide feedback on our recent meta-analysis 5…”

“…It remains to be determined whether TXA plays a role in the long-term follow-up. In the end, we invite you to read and provide feedback on our recent meta-analysis 5 titled “The Efficacy and Safety of Tranexamic Acid in Foot and Ankle Surgery: A Systematic Review and Meta-analysis of Comparative Clinical Studies.”…”

Response to “Letter Regarding: Tranexamic Acid Utilization in Foot and Ankle Surgery: A Meta-analysis”

“…We have reviewed Dr Kachooei’s article titled “The Efficacy and Safety of Tranexamic Acid in Foot and Ankle Surgery: A Systematic Review and Meta-analysis of Comparative Clinical Studies.” 3 We appreciate the contribution that their article provides to the topic. Both articles need to be interpreted with caution as there is a limited number of patients who have been studied after receiving TXA perioperatively.…”

“…We appreciate Dr Kachooei and team’s recommendation to use a different quality assessment tool (GRADE). In their study, 3 Mirghaderi et al also did not use the GRADE assessment tool, but used the same assessment tools that were used in our article. We felt that the assessment tools used in both studies were adequate to assess risk of bias.…”