The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study—Final results

Urquhart,; Templeton, Alexander Allan; Shinewi, F.; Chapman, Michael; Hawkins, Kristina C.; McGarry, James A.; Rodger, Mary W.; Baird, D. T.; Bjornsson, S; Macnaughton, M. C.; Lunan, C. B.; Macrow, P; Elstein, Max; Killick, S.R.; Hill, N. C. W.; Turnbull, A. C.; Mackenzie, I. Z.; Cohn, M.; Stewart, Peter; Bryce, Fiona C.; Lilford, Richard; Johnson, Nick; Li, Tin‐Chiu; Cooke, I. D.; Olajide, F.; Chard, T.; Lim, Boon; Lees, D.A.R.; Subramanyan, V; Grudzinskas, J.G.; Davey, Angela

doi:10.1016/s0010-7824(96)00252-1

Cited by 85 publications

(17 citation statements)

References 14 publications

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“…Urquhatt et al suggested mifepristone and a prostaglandin would be an effective method for pregnancy termination for early medical abortion. 18 Age, maternal age and paritity are comparable with the other studies.…”

Section: Discussionsupporting

confidence: 89%

Sublingual versus vaginal misoprostol for medical termination of pregnancy: a comparative study

Shanmugam

Ghose

Parida

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionsupporting

confidence: 89%

Sublingual versus vaginal misoprostol for medical termination of pregnancy: a comparative study

Shanmugam

Ghose

Parida

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…Hall [1996] suggested that most of the anomalies seen in her three reported cases of attempted terminations of pregnancy with arthrogryposis were compatible with vascular compromise [Leist and Grauwiler, 1974;Webster et al, 1987;Lipson et al, 1989;Robertson et al, 1992;Lipson and Webster, 1993;Hall, 1996]. Those and subsequent publications concerning the abnormalities seen in failed prostaglandin (with or without methrotrexate) terminations of pregnancy, also suggests that congenital contractures were frequently seen and that vascular compromise contributed to the anomalies seen in infants who survive medical [Collins and Mahoney, 1983;Fonseca et al, 1993;Gonzalez et al, 1993Gonzalez et al, , 1998Peyron et al, 1993;Urquhart et al, 1997;Blanch et al, 1998;Yedlinsky et al, 2005;Willmott et al, 2008;Miller et al, 2009;Piggott et al, 2011].…”

Section: Discussionmentioning

confidence: 96%

“…Failures occur with dilation and curettage (D&C), dilation and extraction (D&E), as well as with prostaglandin/medical terminations [Achelis, 1950;Hodgson and Portmann, 1974;Stringer et al, 1975;Stadler and Hardt, 1976;Pelosi et al, 1977;Wulff and Freiman, 1977;Fielding et al, 1978;Hardt et al, 1980;Hundsd€ orfer and Schultz, 1982;Collins and Mahoney, 1983;Jonas, 1985;Kaunitz et al, 1985;Barker and Wade, 1991;Steier and Bergsjø, 1992;Fonseca et al, 1993;Gonzalez et al, 1993Gonzalez et al, , 1998Peyron et al, 1993;Holmes, 1995;Ricciotti et al, 1995;Urquhart et al, 1997;Blanch et al, 1998;Sitruk-Ware et al, 1998;Jermy et al, 1999;P€ ohls et al, 2000;Willmott et al, 2008;Miller et al, 2009;Allanson et al, 2011]. Numbers do not exist for the failure of illegal or illicit attempts to terminate pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Estimates range from 0.02% to 0.07% when termination was under taken by dilation and curettage or dilation and extraction [Hodgson and Portmann, 1974;Pelosi et al, 1977;Wulff and Freiman, 1977;Fielding et al, 1978;Kaunitz et al, 1985;Barker and Wade, 1991;Steier and Bergsjø, 1992;Ricciotti et al, 1995;Sitruk-Ware et al, 1998;P€ ohls et al, 2000]. Data do not exist for FTP for manual vacuum extraction or for medical terminations, although clubfeet and arthrogryposis (multiple congenital contractures) have been reported in failed prostaglandin (medical) terminations [Collins and Mahoney, 1983;Fonseca et al, 1993;Gonzalez et al, 1993Gonzalez et al, , 1998Peyron et al, 1993;Urquhart et al, 1997;Blanch et al, 1998;Willmott et al, 2008;Miller et al, 2009], a frequency has not been established. Most reported survivors of FTP are said to be normal, however, long-term follow-up is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Arthrogryposis (multiple congenital contractures) associated with failed termination of pregnancy

Hall

2012

American J of Med Genetics Pt A

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The purpose of this study was to establish whether an increase in failed termination of pregnancy is observed among individuals with arthrogryposis (multiple congenital contractures). A total of 2,500 unselected patients with arthrogryposis collected by the author over a 35-year period were reviewed. The cases included referrals, consultations, personal examinations, and correspondence. They were reviewed for clinical features, pregnancy complications, family history, and a history of attempted terminations of the pregnancy. Eleven cases of failed terminations of pregnancy in which the individuals were subsequently born with arthrogryposis were identified. We conclude that infants who survive attempted termination of pregnancy (both surgical and medical) may be at an increased risk to be born with multiple congenital contractures. Careful examination of the tissue and a post-procedure ultrasound will help to assure that the termination has been successful. Those infants surviving attempted termination of pregnancy who have arthrogryposis are also at >50% risk for intellectual disability.

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“…[1][2][3][4] The efficacy rate for complete abortion ranges from 87% to 97%. 5 Although misoprostol can be administered orally, buccaliy, sublingually or vaginally, it is seen that vaginal administration of misoprostol is more effective and better tolerated than oral.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Trial of Hospital Vs Home Self Administration of Vaginal Misoprostol for Medical Abortion

Shrestha¹,

Sedhai²

2015

Kathmandu Univ. Med. J.

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BackgroundA combination of mifepristone followed after 24 hrs by misoprostol has proved a safe and effective abortifacient for termination of early pregnancy. Home use of misoprostol for medical abortion is still controversial in many countries including ours where women's literacy rate is low. Particularly in developing countries, this method markedly decreased the hospital visit which would be beneficial to patients and hospital staff. ObjectiveTo see whether the home self administration of vaginal misoprostol was equally effective as administered by trained staff in terms of successful termination of early pregnancy. Secondary outcomes were bleeding and pain duration during medical abortion, side effects, reason for termination of pregnancy and women's acceptability of the procedure. MethodOne hundred and eighty eight women requesting medical abortion with pregnancy less than 63 days gestation were randomized into two groups either self administration of vaginal misoprostol (800 mcg) at home or hospital administration 24 hours after oral 200 mg mifepristone. Ultrasound was performed after 14 days to confirm complete abortion. ResultThe overall success rate was similar in two groups: 89.13% on home group Vs 86.9% in hospital group. Eleven out of 18 women (61.1%) having incomplete abortion had successful termination after 2 nd dose misoprostol( 400 mcg). None of the women had continued pregnancy. Multigravida had slightly higher risk of failure (R.R: 1.04). ConclusionHome self administration of vaginal misoprostol was safe and effective for early termination of medical abortion and was acceptable. Use of extra dose of misoprostol has advantage of higher completion rate of abortion.

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The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study—Final results

Cited by 85 publications

References 14 publications

Sublingual versus vaginal misoprostol for medical termination of pregnancy: a comparative study

Sublingual versus vaginal misoprostol for medical termination of pregnancy: a comparative study

Arthrogryposis (multiple congenital contractures) associated with failed termination of pregnancy

A Randomized Trial of Hospital Vs Home Self Administration of Vaginal Misoprostol for Medical Abortion

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