The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield for cervical dentin hypersensitivity: a pilot randomized controlled trial

Abstract

Background Recently, a novel zinc-containing desensitizer, CAREDYNE Shield, was developed. This new type of desensitizer induces chemical occlusion of dentinal tubules for desensitization and releases zinc ion for root caries prevention. Despite these features, its clinical effectiveness in the improvement of cervical dentine hypersensitivity remains to be elucidated. Thus, we aimed to evaluate the effectiveness of CAREDYNE Shield in patients with CDH. Methods Forty CDH teeth which matched the eligibility criteria were randomly allocated to two groups in a 1:1 ratio: the CAREDYNE Shield group (intervention group) and the Nanoseal group (control group). The pain intensity in response to air stimuli, gingival condition, and oral hygiene status of CDH teeth were assessed before and at 4 weeks after treatment. The primary outcome was the reduction of pain intensity in response to air stimuli from baseline to 4 weeks after intervention. Results From November 2019 to April 2021, 24 participants with 40 teeth were enrolled in this study and 33 teeth in 20 participants were assessed at 4 weeks after treatment. A significant reduction of pain in response to air stimuli was observed in both groups; however, no significant difference was observed between the groups. Conclusions This study showed that CAREDYNE Shield is effective for CDH and its effectiveness is similar to Nanoseal. Trial registration UMIN Clinical Trials Registry (UMIN-CTR), UMIN000038072. Registered on 21st September 2019, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000043331

The Effect of Dentine Desensitizing Agents on the Retention of Cemented Fixed Dental Prostheses: A Systematic Review

“…Recent studies have demonstrated that new types of DAs have comparable desensitizing effects on dentine. These include nano-hydroxyapatite (n-HAp) [ 21 , 22 , 23 ], photobiomodulation therapy (PBM) with a low-level infrared laser [ 24 ], nano-sized carbonate apatite (n-CAP) [ 25 ], zinc-containing desensitizer [ 26 ], etc. Most of the DAs block the opening of the bulk of the dentinal tubules and make the dentinal surface smooth by filling the irregularities, thereby decreasing the sensitivity [ 14 , 15 , 16 , 17 ].…”

Clinical Evaluation of the Use of Desensitizing Agents in the Management of Dentinal Hypersensitivity

“…Several studies report the application of n-HAp as biomimetic material for enamel reconstruction after tooth mineral component loss, thanks to its aforementioned unique remineralization potential [19][20][21][22][23][24][25][26]. N-HAp toothpaste showed promising results in DH management and post-bleaching-related sensitivity [27][28][29].…”