The efficacy of a paeoniflorin-sodium alginate-gelatin skin scaffold for the treatment of diabetic wound: An in vivo study in a rat model

Yu, Hongxiang; Wen, Gongjian; Mei, Junhao; Qin, Lihao; Piao, Zeyu; You, Deshu; Gu, Wei; Jia, Zhongzhi

doi:10.1016/j.biopha.2022.113165

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…In this case, the body cannot return to the normal wound healing sequence by itself, and it is necessary to assist the body by administering drugs. Yu et al applied a skin scaffold made of PF-sodium alginate-gelatin to the wounds of diabetic rats and found that the 3% PF skin scaffold promoted wound healing by promoting collagen deposition and microvascular regeneration; in addition, this scaffold also exhibited anti-inflammatory properties [ 260 ]. Khaliq et al prepared a cefotaxime sodium (CTX)-loaded keratin (KR)-pullulan (PL)-PVA hydrogel film dressing that was shown to accelerate wound healing in diabetic rats by reducing inflammation, recruiting fibroblasts for tissue regeneration, depositing mature collagen, and increasing angiogenesis [ 137 ].…”

Section: Bioactivators For Dusmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies. Graphical Abstract This review defines different types of hydrogels and carefully elaborate the mechanisms by which they repair diabetic ulcers (DUs), summarizes the pathological process of DUs, and reviews various bioactivators used for their treatment.

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Section: Bioactivators For Dusmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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“…The topical application of the paeoniflorin-enriched gel brought better inflammation management, improved angiogenesis, reepithelialization, and collagen deposition (Yang et al, 2021). Other studies using a paeoniflorin-sodium alginate-gelatin skin scaffold for Frontiers in Pharmacology frontiersin.org treating diabetic wounds in a rat model gave positive results on macrophage modulation as well (Yu et al, 2022). Oxypaeoniflorin, a metabolite found in P. lactiflora root, has been studied for its antioxidative and anti-inflammatory activities when it has been associated with paeoniflorin.…”

Section: Paeonia Lactiflora Rootmentioning

confidence: 99%

“…The topical application of the paeoniflorin-enriched gel brought better inflammation management, improved angiogenesis, re-epithelialization, and collagen deposition ( Yang et al, 2021 ). Other studies using a paeoniflorin-sodium alginate-gelatin skin scaffold for treating diabetic wounds in a rat model gave positive results on macrophage modulation as well ( Yu et al, 2022 ).…”

Section: Wound-healing Herbal Topical Therapies From Kampomentioning

confidence: 99%

Kampo herbal ointments for skin wound healing

Paul-Traversaz

Umehara²,

Watanabe³

et al. 2023

Front. Pharmacol.

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The management of skin wound healing problems is a public health issue in which traditional herbal medicines could play a determining role. Kampo medicine, with three traditionally used ointments, provides interesting solutions for these dermatological issues. These ointments named Shiunkō, Chuōkō, and Shinsen taitsukō all have in common a lipophilic base of sesame oil and beeswax from which herbal crude drugs are extracted according to several possible manufacturing protocols. This review article brings together existing data on metabolites involved in the complex wound healing process. Among them are representatives of the botanical genera Angelica, Lithospermum, Curcuma, Phellodendron, Paeonia, Rheum, Rehmannia, Scrophularia, or Cinnamomum. Kampo provides numerous metabolites of interest, whose content in crude drugs is very sensitive to different biotic and abiotic factors and to the different extraction protocols used for these ointments. If Kampo medicine is known for its singular standardization, ointments are not well known, and research on these lipophilic formulas has not been developed due to the analytical difficulties encountered in biological and metabolomic analysis. Further research considering the complexities of these unique herbal ointments could contribute to a rationalization of Kampo’s therapeutic uses for wound healing.

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“…In this regard, this study focuses on (1) improving poor structural integrity and stability properties of ALG using the shear-thinning property of XAN, (2) enhancing the biological activities while minimizing bacterial infections and oxidative stress by incorporating CLV as a natural phytotherapeutic agent, and finally, (3) developing novel antioxidant, antibacterial and anti-inflammatory 3D-printed hydrogel structures for wound healing applications. Herein, a surface topography with grid-like structure was chosen to produce 3D-printed hydrogel scaffolds in order to achieve efficient gas exchange and cell adhesion. , Then, the physical, chemical, and mechanical properties of 3D-printed ALG-XAN hydrogels containing different concentrations of CLV were investigated. In addition, wound dressings are usually required to be changed 1–3 times a week to prevent microbial contamination, particularly in the inflammatory phase .…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

Ünalan

Schruefer

Schubert

et al. 2023

ACS Biomater. Sci. Eng.

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This study aimed to develop three-dimensional (3D)-printed hydrogels containing phytotherapeutic agents as multifunctional wound dressings. In this regard, 3D-printed sodium alginate (ALG)−xanthan gum (XAN) hydrogels incorporated with different clove essential oil (CLV) concentrations were produced by the extrusion-based 3D-printing technology. Rheology measurements, filament fusion, and filament collapse analyses indicated that XAN's blending overcame the challenges associated with ALG's printability and shape fidelity. Attenuated total reflection-Fourier-transform infrared (ATR-FTIR) spectra and total phenolic content assay confirmed the presence of CLV in the 3D-printed hydrogels. Additionally, the releasing profile showed that CLV exhibited long-term release for up to 28 days. Furthermore, the incorporation of CLV increased 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging while reducing the S. aureus and E. coli relative bacterial viability; thereby, the CLV incorporation enhanced the 3Dprinted ALG−XAN hydrogel antioxidant and antibacterial activity. In addition, anti-inflammatory activity was assessed using Raw 264.7 macrophage-like cells, and the results demonstrated that CLV reduced nitric oxide (NO) concentration in medium, indicating a potential anti-inflammatory effect. Moreover, in vitro cytotoxicity results showed that the incorporation of CLV has no toxic effect on NHDF cells, whereas the proliferation of NHDF cells exhibited a dose-dependent response. In conclusion, the present study shows not only the development of a new ALG-XAN biomaterial ink but also the potential benefit of natural phytotherapeutics incorporated into 3D-printed hydrogels as a multifunctional wound dressing.

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The efficacy of a paeoniflorin-sodium alginate-gelatin skin scaffold for the treatment of diabetic wound: An in vivo study in a rat model

Cited by 19 publications

References 18 publications

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Kampo herbal ointments for skin wound healing

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

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