The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin

Abstract

ObjectiveDry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.MethodsThirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.ResultsSkin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16®.ConclusionFrom these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.

Efficacy of hydrophilic or lipophilic emulsions containing <em>Echinacea purpurea</em> extract in treatment of different types of pruritus

“… 17 In addition, a recent study investigating a emulsion containing pseudo-ceramide and eucalyptus extract showed effectively improved dry and scaly scalp as well as the quality of life of 34 participants with different skin conditions (atopic dermatitis, seborrheic dermatitis, pityriasis capitis). 18 …”

Understanding the Characteristics of the Scalp for Developing Scalp Care Products

“…Especially, scaling, erythema, and itching were significantly improved. The skin barrier function of the scalp was greatly improved [36]. Although this study was performed on patients with certain skin disorders, its results are also of value in the general population with weak scalp skin barriers.…”

Role of lipids in skin barrier properties

“…Показано, что экзогенные компоненты ЛТ проникают через роговой слой в клетки зернистого слоя эпидермиса; проходят через эндоплазматический ретикулум в сеть аппарата Гольджи, где формируются ЛТ. Показано, что использование увлажняющих препаратов замедляет прогрессию АтД и снижает тяжесть заболевания [30,31]. K. Mori и соавт.…”

“…Авторы показали, что в сухой летний период использование геля значительно улучшало состояние кожи, снижало покраснение, зуд, улучшало самочувствие больных по сравнению с больными, не использовавшими гель. Аналогичные данные были получены у больных себорейным дерматитом [31]. Этот же состав увлажняющего средства в сочетании с умеренной очисткой лица оказывал достоверный протективный эффект при акне средней тяжести у подростков с сухой и чувствительной кожей [32].…”