The efficacy of a topical gel with triester glycerol oxide in denture‐related mucosal injuries

Abstract

The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuriesObjective: The efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel. Materials and methods: Fifty edentulous patients were enrolled in this double-blind clinical study. All subjects received new maxillary and mandibular complete dentures and were recalled 1, 3 and 7 days after denture placement. Twenty-five subjects received topical gel with triester glycerol oxide (TGO), and 25 subjects received topical gel without TGO. At each visit, pain and discomfort with the new dentures was assessed, and at the last visit, healing of ulcerations was also graded by a clinician. Subjects also graded the gel's taste, smell and ease of use. Results: Specifically, there was no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons). Conclusion: Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.

Effects of a Hydrogel Patch on Denture‐Related Traumatic Ulcers; an Exploratory Study

“…Similar to our results, a 1996 study reported that patients claimed reduced healing time of aphthous ulcers due to treatment with bioadhesive hydrogel patches made from a pharmaceutical grade cellulose derivative . In contrast, application of topical gel with and without triester glycerol oxide (without containment in a patch) in denture‐related mucosal injuries was not effective for treating injuries from new full dentures . No prior reports have described the use of any hydrogel patch for denture‐related ulcerations.…”

“…14 In contrast, application of topical gel with and without triester glycerol oxide (without containment in a patch) in denture-related mucosal injuries was not effective for treating injuries from new full dentures. 15 No prior reports have described the use of any hydrogel patch for denture-related ulcerations.…”

An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial

“…According to our knowledge this is the first randomized, double-blind, placebo-controlled clinical trial investigating the effects of TGO gel in the treatment of RAS. In a placebo controlled study, the efficacy of TGO gel in the treatment of the ulcerations related to new complete denture have been investigated and TGO gel found ineffective (13). …”

“…Following its use a significant reduction of the number of erythrocytes and inflammatory cells and a significant increase of mature epithelial cells of oral mucosa were reported (13). TGO gel also has been shown to reduce RAS related symptoms, such as pain and was found effective in lengthening the duration of recurrence time (13).…”

“…Following its use a significant reduction of the number of erythrocytes and inflammatory cells and a significant increase of mature epithelial cells of oral mucosa were reported (13). TGO gel also has been shown to reduce RAS related symptoms, such as pain and was found effective in lengthening the duration of recurrence time (13). The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine the efficacy of a topical TGO gel and also compare with TA pomade in the treatment of minor recurrent aphthous stomatitis in a group of Turkish patients.…”