The efficacy of a working memory training in substance use patients: A randomized double-blind placebo-controlled clinical trial

Wanmaker, Sabine; Leijdesdorff, Sophie; Geraerts, Elke; Wetering, B.J.M. van de; Renkema, Peter J.; Franken, Ingmar H.A.

doi:10.1080/13803395.2017.1372367

Cited by 42 publications

(30 citation statements)

References 79 publications

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“…Neurostimulation that targets the dorsolateral prefrontal cortex, a key brain area in working memory (Petrides, 2000), decreases craving across different substances (Jansen et al, 2013). Preliminary findings from targeted cognitive training interventions support the role of WM in reducing or stabilizing drug use in community and clinical samples (Houben, Wiers, & Jansen, 2011;Rass et al, 2015;Verdejo-Garcia, 2016), although recent findings on these interventions are mixed (Khemiri, Brynte, Stunkel, Klingberg, & Jayaram-Lindstrom, 2018;Wanmaker et al, 2018). Yet despite a strong theoretical basis, there are no data evaluating that WM indeed modulates substance craving in association with drug cues or stressful contexts.…”

mentioning

confidence: 99%

Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives

Miranda

Wemm

Padovano

et al. 2019

Clinical Psychological Science

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Theories of addiction posit that stimuli associated with drug use, including both exteroceptive (e.g., paraphernalia) and interoceptive (e.g., feeling tense or stressed), evoke craving and contribute to the pathogenesis of substance misuse. Control over drug cue response and stress is essential for moderating use. Building from laboratory data supporting associations between cue exposure, stress, and craving, this study tested whether these associations generalize to real-world settings and examined whether a well-vetted neurocognitive control capacity (i.e., working memory, or WM) moderated associations. Youths ( N = 85; 15–24 years old) completed baseline and ecological momentary assessments. Cue exposure and participants’ average stress predicted higher craving. Youths with weaker WM experienced stronger craving at higher-stress moments but not when faced with cues. Interactions were present for both previous-moment and same-moment stress. Craving among adolescents with stronger WM was not swayed by momentary stress. Findings suggest that stronger WM protects against craving at more stressful moments.

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mentioning

confidence: 99%

Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives

Miranda

Wemm

Padovano

et al. 2019

Clinical Psychological Science

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“…Similarly, studies of methadone maintenance (168) and cannabis (169) have found no evidence of far-transfer effects (e.g., delay discounting), although Rass et al (168) showed WMT-related reductions in street drug use among methadone users. Other forms of WMT (e.g., n-back training) have reported similar near-transfer but not substanceuse-related findings with methamphetamine patients (170) and a mixed group of substance use patients (alcohol, cannabis, cocaine) (164). As such, the greatest limitation in the WMT literature is the failure to consistently examine substance use outcomes and therefore there is insufficient evidence at this time to support the utility of WMT as an effective adjunctive treatment for SUD.…”

Section: Working Memory Training (Wmt)mentioning

confidence: 96%

“…WMT aims to extend WM capacity, so individuals can better integrate, manipulate, and prioritize important information, with the aim of supporting more adaptive decisionmaking that leads to reduced substance use (163). Relative to many other approaches, WMT is intensive, typically requiring 19-25 days of training and as such, retention is often poor (164). While WMT has been shown to lead to improvements in neartransfer effects (i.e., improved performance on similar WM tasks), there is limited evidence supporting far-transfer effects of WMT on other measures of EF and importantly, on substancerelated outcomes (165).…”

Section: Working Memory Training (Wmt)mentioning

confidence: 99%

A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine

et al. 2019

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Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscienceinformed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addiction Medicine (ISAM-NIG) to promote initiatives to bridge this gap. This article summarizes the ISAM-NIG key priorities and strategies to achieve implementation of addiction neuroscience knowledge and tools for the assessment and treatment of substance use disorders. We cover two assessment areas: cognitive assessment and neuroimaging, and two interventional areas: cognitive training/remediation and neuromodulation, where we identify key challenges and proposed solutions. We reason

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“…In contrast to some studies using formal training of working memory (e.g., [83]) to evaluate their direct impact on unhealthy behaviors (e.g., alcohol abuse), which can be positive in nonclinical samples [84], but not clinical population [85], modified versions of response inhibition tasks have served as training paradigms [79,[86][87][88][89][90].…”

Section: Restoring Inhibitory Controlmentioning

confidence: 99%

Addiction: Brain and Cognitive Stimulation for Better Cognitive Control and Far Beyond

Noël¹,

Bechara²,

Saeremans³

et al. 2020

Inhibitory Control Training - A Multidisciplinary Approach

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Addiction behaviors are characterized by conditioned responses responsible for craving and automatic actions as well as disturbances within the supervisory network, one of the key elements of which is the inhibition of prepotent response. Interventions such as brain stimulation and cognitive training targeting this imbalanced system can potentially be a positive adjunct to treatment as usual. The relevance of several invasive and noninvasive brain stimulation techniques in the context of addiction as well as several cognitive training protocols is reviewed. By reducing cue-induced craving and modifying the pattern of action, memory associations, and attention biases, these interventions produced significant but still limited clinical effects. A new refined definition of response inhibition, including automatic inhibition of response and a more consistent approach to cue exposure capitalizing on the phase of reconsolidation of pre-activated emotional memories, all associated with brain and cognitive stimulation, opens new avenues for clinical research.

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The efficacy of a working memory training in substance use patients: A randomized double-blind placebo-controlled clinical trial

Cited by 42 publications

References 79 publications

Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives

Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives

A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine

Addiction: Brain and Cognitive Stimulation for Better Cognitive Control and Far Beyond

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