2013
DOI: 10.1001/2013.jamadermatol.386
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The Efficacy of Afamelanotide and Narrowband UV-B Phototherapy for Repigmentation of Vitiligo

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Cited by 92 publications
(58 citation statements)
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“…Therefore, the proper production of melanin is very important for skin health [1]. Recent studies have demonstrated that vitiligo patients possess defects in the melanocortin system [3,21,22], and afamelanotide, an analogue of α-MSH, is currently undergoing clinical trials for the treatment of vitiligo [22]. Since it is a synthetic peptide, afamelanotide is given via subcutaneous injections, which are inconvenient.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the proper production of melanin is very important for skin health [1]. Recent studies have demonstrated that vitiligo patients possess defects in the melanocortin system [3,21,22], and afamelanotide, an analogue of α-MSH, is currently undergoing clinical trials for the treatment of vitiligo [22]. Since it is a synthetic peptide, afamelanotide is given via subcutaneous injections, which are inconvenient.…”
Section: Discussionmentioning
confidence: 99%
“…Alpha-Melanocyte-stimulating hormone (α-MSH) is a naturally occurring hormone that stimulates melanogenesis {reviewed in (71)}. Afamelanotide, a synthetic analogue of αMSH, is currently approved by the European Medicines Agency to mitigate photosensitivity in erythropoietic protoporphyria (72), and thus may also improve the efficacy of phototherapy for vitiligo (73). Recently, a randomized comparative multicenter trial was conducted to test the safety and efficacy of an afamelanotide subcutaneous implant in combination with NB-UVB in adults with generalized vitiligo.…”
Section: Emerging Treatmentsmentioning
confidence: 99%
“…Psoralen-NB-UVB is more efficacious than NB-UVB phototherapy, producing a greater percentage reduction in vitiligo area severity index scores and requiring a lesser cumulative dose and the response starts earlier (38). Afamelanotide is a potent and longer-lasting synthetic analogue of naturally occurring alpha-melanocyte stimulating hormone (α-MSH), which decreased in vitiligo, Grimes et al (39) found that NB-UVB combined with afamelanotide is safe and effective and that afamelanotide represents a novel and potentially effective treatment for vitiligo, but still needs further studies.…”
Section: Nb-uvbmentioning
confidence: 99%