The efficacy of bone marrow-derived mesenchymal stem cells and/or erythropoietin in ameliorating kidney damage in gamma irradiated rats: Role of non-hematopoietic erythropoietin anti-apoptotic signaling

Asker, Mervat E.; Ali, Sousou I.; Mohamed, Seham H.; Abdelaleem, Rasha Mohamed Ahmed; Younis, Naveed

doi:10.1016/j.lfs.2021.119388

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…ROS interact with cellular biomolecules, resulting in radiation cell injury. 16 Rats on AEDs that undergo fractionated gamma radiation showed a higher level of MDA than the normal control group. This in turn depleted the antioxidant molecules GSH in γ-irradiated rats.…”

Section: Discussionmentioning

confidence: 92%

“…It has previously been demonstrated that BM-MSCs can restore damaged kidneys in radiation-exposed rats. 16 However, this study is the first to examine the role of stem cells in reducing radiation risks in rats receiving antiepileptic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…BM‐MSCs radioprotective effect was formerly proven in radiation‐induced liver, lung, and oral mucosal injuries with enhanced survival at irradiated animals 16 . Notably, signals from the injured kidney may cause transplanted BM‐MSCs to be activated to the damaged site 15 .…”

Section: Introductionmentioning

confidence: 99%

“…BM-MSCs radioprotective effect was formerly proven in radiationinduced liver, lung, and oral mucosal injuries with enhanced survival at irradiated animals. 16 Notably, signals from the injured kidney may cause transplanted BM-MSCs to be activated to the damaged site. 15 On the other hand, the protective and therapeutic abilities of BM-MSCs in radiation-induced kidney injury in patients on AEDs are not well studied.…”

mentioning

confidence: 99%

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Potential impact of mesenchymal stem cells on nephrotoxicity induced by gamma irradiation and antiepileptic drugs cotherapy in rats

Gharib,

Fahmy,

Mohamed

et al. 2023

Cell Biochemistry & Function

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The goal of this study was to assess the influence of bone marrow‐derived mesenchymal stem cells (BM‐MSCs) on the nephrotoxicity induced by fractionated doses of gamma irradiation (Rad) and the cotherapy of levetiracetam and oxcarbazepine in male rats. Adult rats were randomly divided into four groups. Group I: Control, Group II: antiepileptic drugs (AEDs), Group III: AEDs +Rad and Group IV: AEDs + Rad + MSCs. Rats treated with AEDs and exposed to fractionated doses of γ‐irradiation displayed a discernible increase in serum urea, creatinine, kidney injury marker, kidney malondialdehyde, transforming growth factor beta (TGF‐β) and the relative expression of Smad3 along with a decrease in the relative expression of Smad7 and glutathione level. Alternatively, groups treated with BM‐MSCs with AEDs and Rad showed a substantial modification in the majority of the evaluated parameters and looked to be successful in reducing the hazards of the combination therapy of AEDs and radiation. The reno‐histopathological study supports the biochemical analysis. In conclusion, BM‐MSCs exhibited therapeutic potential against nephrotoxicity induced by fractionated doses of γ‐irradiation and AEDs. The outcome was brought about by the downregulation of the TGF‐β/Smad pathway. BM‐MSCs might be suggested as a valuable therapeutic strategy to overcome kidney injury induced by gamma irradiation during AEDs cotherapy.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Potential impact of mesenchymal stem cells on nephrotoxicity induced by gamma irradiation and antiepileptic drugs cotherapy in rats

Gharib,

Fahmy,

Mohamed

et al. 2023

Cell Biochemistry & Function

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“…Exogenous administration of EPO can reduce tissue damage and apoptosis by improving the expression of anti-apoptotic genes and telomerase activity ( 89 ). EPO can activate PI3K/Akt, JAK/STAT signaling pathways and improve ERS, thus enhancing cell repair capacity and resisting apoptosis ( 90 – 92 ).…”

Section: Discussionmentioning

confidence: 99%

Neurological recovery and antioxidant effect of erythropoietin for spinal cord injury: A systematic review and meta-analysis

et al. 2022

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BackgroundTo critically evaluate the neurological recovery effects and antioxidant effects of erythropoietin (EPO) in rat models of spinal cord injury (SCI).MethodsThe PubMed, EMBASE, MEDLINE, ScienceDirect, and Web of Science were searched for animal experiments applying EPO to treat SCI to January 2022. We included studies which examined neurological function by the Basso, Beattie, and Bresnahan (BBB) scale, as well as cavity area and spared area, and determining the molecular-biological analysis of antioxidative effects by malondialdehyde (MDA) levels in spinal cord tissues. Meta-analysis were performed with Review Manager 5.4 software.ResultsA total of 33 studies were included in this review. The results of the meta-analysis showed that SCI rats receiving EPO therapy showed a significant locomotor function recovery after 14 days compared with control, then the superiority of EPO therapy maintained to 28 days from BBB scale. Compared with the control group, the cavity area was reduced [4 studies, weighted mean difference (WMD) = −16.65, 95% CI (−30.74 to −2.55), P = 0.02] and spared area was increased [3 studies, WMD =11.53, 95% CI (1.34 to 21.72), P = 0.03] by EPO. Meanwhile, MDA levels [2 studies, WMD = −0.63 (−1.09 to −0.18), P = 0.007] were improved in the EPO treatment group compared with control, which indicated its antioxidant effect. The subgroup analysis recommended 5,000 UI/kg is the most effective dose [WMD = 4.05 (2.23, 5.88), P < 0.0001], although its effect was not statistically different from that of 1,000 UI/kg. Meanwhile, the different rat strains (Sprague-Dawley vs. Wistar), and models of animals, as well as administration method (single or multiple administration) of EPO did not affect the neuroprotective effect of EPO for SCI.ConclusionsThis systematic review indicated that EPO can promote the recovery of the locomotor function of SCI rats. The mechanism exploration of EPO needs to be verified by experiments, and then carefully designed randomized controlled trials are needed to explore its neural recovery effects.

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Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma‐irradiation‐induced chronic nephrotoxicity in rats

Eassawy,

Ismail

2023

Environmental Toxicology

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The prevalence of chronic kidney disease (CKD) is in progress that causes kidney failure, leading to global problems. This manuscript investigated the nephroprotective effects of chicory (CLE) and/or artichoke (ALE) leaves extracts on carbon tetrachloride (CCl4) and gamma‐irradiation (Rad)‐induced chronic nephrotoxicity in rats. Rats were divided into 10 groups (10 animals/group): group 1: control, groups 2–7 rats were treated with CLE, ALE, CLE/ALE, CCl4, Rad, and CCl4/Rad, respectively. Groups 8 to 10, rats were intoxicated with CCl4/Rad, and treated with CLE, ALE, and CLE/ALE extracts, respectively, for 4 weeks. The data demonstrated that CCl4 administration or Rad exposure induced high levels of urea and creatinine, with low levels of total protein and albumin in the serum. However, high levels of malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2), some pro‐inflammatory markers such as interleukins (IL‐1β, IL‐2, IL‐6), TNF‐α, NF‐κB, the fibrotic marker; TGF‐β1, calcium, and copper, low contents of reduced glutathione (GSH), iron, and zinc, and suppression of the antioxidant enzymes' activity, superoxide dismutase (SOD), and catalase (CAT) were observed. In addition, the Wnt and β‐catenin protein expression ratios were up‐regulated in the kidney tissues of the CCl4, and Rad intoxicated animals. However, the combined treatment CCl4/Rad augmented these measurements. On the other hand, CLE, ALE, and CLE/ALE treatments demonstrated nephroprotection in the kidney tissues of CCl4/Rad intoxicated animals, in the order of CLE/ALE>ALE>CLE by ameliorating the investigated parameters. Kidney tissues' histopathological examinations confirmed these results. In conclusion, CLE and/or ALE demonstrated nephroprotection against CCl4/Rad co‐toxicity mediated by down‐regulation of renal Wnt/β‐catenin protein expressions.

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The efficacy of bone marrow-derived mesenchymal stem cells and/or erythropoietin in ameliorating kidney damage in gamma irradiated rats: Role of non-hematopoietic erythropoietin anti-apoptotic signaling

Cited by 5 publications

References 35 publications

Potential impact of mesenchymal stem cells on nephrotoxicity induced by gamma irradiation and antiepileptic drugs cotherapy in rats

Potential impact of mesenchymal stem cells on nephrotoxicity induced by gamma irradiation and antiepileptic drugs cotherapy in rats

Neurological recovery and antioxidant effect of erythropoietin for spinal cord injury: A systematic review and meta-analysis

Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma‐irradiation‐induced chronic nephrotoxicity in rats

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