The efficacy of change in limb volume on functional mobility, health-related quality of life, social appearance anxiety, and depression in patients with lower extremity lymphedema

Şahinoğlu, Ertan; Ergin, Gülbin; Karadibak, Didem

doi:10.1177/02683555211061011

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…[20][21][22][23][24] Similarly, in patients with lymphedema, limb volume reduction has demonstrated improvement in the mobility of patients with obesity. 25 This suggests the risk of VTE is higher in the elderly individuals with lymphedema and may also be observed in lipedema. Because limited mobility is common to lymphedema and lipedema and is more frequent in patients with obesity, this may potentiate the over-all combined risk of VTE.…”

Section: Discussionmentioning

confidence: 99%

Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample

Khalid,

Prasada,

Jennings

et al. 2024

Vasc Med

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Background: Patients with lymphedema and lipedema share physical exam findings that may lead to misdiagnosis. Poor mobility is common in patients with obesity and patients with lymphedema and lipedema. This may constitute a risk factor for venous thromboembolism (VTE). Our objective was to evaluate the association of VTE in obese patients with lymphedema and lipedema. Methods: The National Inpatient Sample (NIS) was searched from 2016 to 2020 to identify hospital admissions of obese female patients with lymphedema and lipedema. Patients were analyzed in the context of presence or absence of VTE while adjusting for complex cluster sampling techniques. Predictors of VTE were accessed by multivariable regression. Results: Lymphedema was identified in 189,985 patients and lipedema in 50,645 patients. VTE was observed in 3.12% ( n = 374,210) of patients with obesity. In patients with obesity, VTE was more common in patients with lymphedema than without (2.6% vs 1.6%; p < 0.01). Similarly, VTE was more common in patients with lipedema than without (0.6% vs 0.4%; p < 0.01). After multivariable logistic regression, VTE events in obese patients with lymphedema were higher versus without (OR 1.6; CI 1.08–2.43; p = 0.02). Similarly, VTE events were more common in obese patients with lipedema versus obese patients without lipedema (OR 1.20; CI 1.03–1.41; p = 0.02). Conclusions: In this hypothesis-generating study, lymphedema and lipedema show a positive association with VTE after adjusting for baseline patient characteristics such as obesity, which is a known independent risk factor for VTE. Mechanisms whereby lymphedema and lipedema are associated with VTE should be investigated.

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Section: Discussionmentioning

confidence: 99%

Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample

Khalid,

Prasada,

Jennings

et al. 2024

Vasc Med

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“…The increase in patients with malignant tumors has led to the rise in patients with secondary limb lymphedema, which seriously affects mental health and quality of life. 20,23,24 The accompanying derangement in esthetics and functioning possibly leads to depression, anxiety, and a negative body image. 25 Secondary lower limb lymphedema is a common complication of cancer treatment, which frequently follows the radical resection of endometrial cancer, ovarian cancer, bladder cancer, and other malignant tumors, simple lymph node dissection, tumor radiotherapy, and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The calculation formula for the score of the Lymph-ICF-LL full scale and subscale is (the sum of the scores of the questions answered/the number of answered questions) × 10; hence, the score range of the full scale and each subscale is from 0 to 100. Five levels of lower limb lymphedema were identified using overall and subscale scores of Lymph-ICF-LL: no edema (score 0-4), mild edema (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), moderate edema (25-49), severe edema (50-95), and very severe edema (96-100). Research results have shown that Lymph-ICF-LL has good reliability and validity in both Chinese version 20 and other language versions.…”

Section: Lower Extremity Lymphedema Indexmentioning

confidence: 99%

Application of indocyanine green lymphography combined with methylene blue staining in lymphaticovenular anastomosis of lower limb vessels: A prospective study

et al. 2023

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Background Methylene blue (MB) is a conventional lymphatic tracer. We evaluated the application of indocyanine green (ICG) lymphography combined with MB staining in lower limb lymphaticovenular anastomosis (LVA). Methods A total of 49 patients with lower limb lymphedema were selected as the study subjects and divided into the research ( n = 27) and control groups ( n = 22). The patients were treated with LVA using ICG lymphography combined with MB staining and simple ICG lymphography as the positioning method, respectively. The number of lymphatic vessels anastomosed and the operating time were compared between the groups. Lower Extremity Lymphedema Index (LEL index) and Lymphoedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphoedema (Lymph-ICF-LL) were used as prognostic indices; 6 months after LVA, both groups were evaluated for the symptomatic relief of lymphedema. Results The number of anastomotic lymphatic vessels in the study group was higher than that in the control group ( p < .05), and their procedural time was shorter than that in the control group. The two groups had no significant difference in lymphatic anastomosis time ( p > .05). The LEL index and Lymph-ICF-LL of the research and control groups at 6-month follow-up after LVA were lower than those before the operation ( p < .05). Conclusion The circumference of the affected limb is reduced after LVA in patients with lower extremity lymphedema with a favorable prognosis. ICG lymphography combined with MB staining has the advantages of real-time visualization and accurate localization.

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“…If not intervened in time, the lesion site may permanently severe swelling, leading to disability, which will have a tremendous negative impact on the patient's physical and psychological state. 6,7 Currently, the treatment methods for lymphedema include conservative treatment, lesion tissue resection, liposuction, lymphaticovenular anastomosis (LVA), and lymph node transplantation. [8][9][10][11] With the progress of microsurgery equipment and technology, super microsurgery has been used to perform LVA in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…If not intervened in time, the lesion site may permanently severe swelling, leading to disability, which will have a tremendous negative impact on the patient’s physical and psychological state. 6,7…”

Section: Introductionmentioning

confidence: 99%

Application of complete decongestive therapy after lymphaticovenular anastomosis of the lower limb combined with liposuction-A retrospective study research

Zhou,

Ma,

et al. 2023

Phlebology

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Background Complete decongestive therapy (CDT) is a conservative treatment for lymphedema that combines interventions and lifestyle changes. We evaluated the application of CDT after lymphaticovenular anastomosis (LVA) of the lower limb combined with liposuction. Methods A total of 55 patients who underwent LVA of the lower limb combined with liposuction from January 2021 to July 2022 were enrolled in the study. The patients were divided into groups A ( n = 24) and B ( n = 31) according to whether they adhered to CDT treatment during the 12-month follow-up. Group A was the non-adherence CDT group and Group B was the adherence CDT group. Lower Extremity Lymphedema Index (LELI) and Lymphoedema Functioning, Disability, and Health Questionnaire for Lower Limb Lymphoedema (Lymph-ICF-LL) were used as prognostic indicators to observe the remission of postoperative lymphedema symptoms in the two groups. Results At 6-month and 12-month follow-up, LELI and the score of Lymph-ICF-LL in group B and group A were lower than before the operation ( p < .05). The circumference of the affected limb was reduced, and the quality of life was improved in both groups after the operation. The reduction of LELI and Lymph-ICF-LL in group B was higher than in group A, and the difference was statistically significant ( p < .05). Conclusion This study preliminarily proves the effectiveness of CDT after LVA of the lower limb combined with liposuction, which can maintain and strengthen the surgical effect. Further, CDT treatment is still needed after the operation, which is necessary to reduce the circumference of the affected limb and improve patients’ quality of life.

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The efficacy of change in limb volume on functional mobility, health-related quality of life, social appearance anxiety, and depression in patients with lower extremity lymphedema

Cited by 7 publications

References 27 publications

Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample

Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample

Application of indocyanine green lymphography combined with methylene blue staining in lymphaticovenular anastomosis of lower limb vessels: A prospective study

Application of complete decongestive therapy after lymphaticovenular anastomosis of the lower limb combined with liposuction-A retrospective study research

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