The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study

Abstract

Background. A dry socket also referred to as alveolar osteitis (AO) is a common postoperative complication following tooth extraction, due to the disruption of the clot within the wound. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in the healing of alveolar osteitis following tooth extraction. Methods. The study was conducted at University Dental Hospital Sharjah, UAE. Patients undergoing tooth extraction at the oral surgery clinic were advised to return immediately if they suffer from pain. Over the following first week after tooth extraction, patients who reported pain symptoms were recalled and all dry sockets were identified. The patients were divided into two groups. Group I patients received conventional treatment with socket curettage and saline irrigation only, while in group II CGF was inserted into the socket. Both groups were observed for pain score and quantification of granulation tissue formation. Results. A total of 40 dry socket patients, aged between 18 and 60 years, from a total of 1,250 patients, were included in the study. 30 patients were given conventional treatment while another 10 patients were given CGF. Patients who received CGF had a pain score of 7–10 at presentation, and the pain score dropped to 0–3 on day 4 and further improved to 0-1 on day 7 (p=0.001). Granulation tissue formation appeared in the conventional group I on day 7 while the CGF group II showed earlier granulation tissue formation by day 4 (p=0.001). The posttreatment pain score is inversely proportional to the amount and rate of granulation tissue formation in the socket. Conclusion. The study suggests that delivery of CGF into a dry socket helps relieve pain and expedite the wound healing process as shown by a statistically much lower pain score and earlier and more rapid formation of granulation tissue when compared to the conventional alveolar osteitis therapy.

Clinical management of alveolar osteitis. A systematic review

“…Thus, 40 records were eligible for full-text reading; of these, 1 was a retracted article, 1 was removed for double publication, 2 were not in English or Spanish language, 2 were non-indexed articles, 4 did not register pain control as a variable as well as 13 others studies had lack of data regarding pain control or records whose categorization was not adapted to the inclusion criteria. Finally, there were included 17 studies ( 8 , 9 , 13 - 27 ). Fig.…”

“…New therapeutic approaches were developed during the last decades. Among them, platelet-rich fibrin (PRF) is currently widely used in AO cases ( 8 , 9 ). However, there are no treatment standardized protocols.…”

Concentrated Growth Factors vs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. A Longitudinal Comparative Study

“…Özveri Koyuncu et al in 2019 reported significant benefits of CGF as compared to spontaneous healing in soft tissue healing, postoperative pain, swelling, and trismus after third molar surgery [34]. Kamal et al in 2020 reported that CGF is effective in relieving pain and expedite wound healing as compared to conventional treatment alone, represented by socket curettage and saline irrigation, in alveolar osteitis [35]. In another three-arm trial, Kamal et al compared CGF, low-level laser therapy (LLLT) and conventional treatment (gentle socket curettage and saline irrigation) for the management of dry sockets [36].…”

Formulation development and evaluation of lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrolyte complex for dry socket treatment

“…Dry socket pain starts one to three days after extraction or surgical removal of a wisdom tooth and usually presents with metallic dysgeusia and halitosis ( Shevel, 2018 ). The pain (which can be 7–10 on the pain scale) is a significant problem in dry socket patients ( Kamal et al, 2020 ), requiring administration of a topical analgesic ( Metin et al, 2006 ). The primary objective for dry socket treatment is to attenuate the pain severity until sufficient epithelium granulation occurs to cover bone and nerve. The epithelialization time is variable but may be completed within 5 to 10 days ( Veale, 2015 ).…”