The efficacy of conditioned media of adipose-derived stem cells combined with ablative carbon dioxide fractional resurfacing for atrophic acne scars and skin rejuvenation

Zhou, Bingrong; Zhang, Ting; Jameel, Afzaal Ahmed Bin; Xu, Yang; Xu, Yan; Guo, Shilei; Wang, Ying; Permatasari, Felicia; Luo, Dan

doi:10.3109/14764172.2015.1114638

Cited by 68 publications

(70 citation statements)

References 27 publications

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“…Improvement of skin functions after stem cells treatment was also reported in our previous study conducted on wound healing, in addition to Bing Rog Zohu et al ., who also found that stem cells improve TEWL and skin hydration in atrophic acne scar model.…”

Section: Discussionsupporting

confidence: 81%

“…Our FxCR results were consistent with previous reports of Chapas et al ., Manuskiatti et al, and Cho et al, who all concluded that carbon dioxide ablative fractional resurfacing is effective and well tolerated for the treatment of atrophic acne scars. On the other hand, Bing‐rong Zhou et al . involved AT‐ASCs and FxCR treatment for acne scars but in a different pattern than our study, where they used AT‐ASCs as an adjuvant treatment to FxCR to reduce its side effects and have suggested that topical ADSC‐CM can be used as an adjuvant therapy after FxCR and not as a stand alone treatment for such cases as this group was not included in their study.…”

Section: Discussionmentioning

confidence: 68%

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Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

et al. 2019

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Background Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory; instead, employing multiple modalities may have better outcome. Autologous adipose tissue‐derived adult stem cells (AT‐ASCs) and their secretory factors can stimulate collagen synthesis; angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also, conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. The aim of the study was to verify the effectiveness of AT‐ASCs for the treatment of acne scarring vs. the fractional carbon dioxide laser (FxCR). Subjects and methods Split face comparative study included 10 adult patients with post‐acne scars on both sides of the face. One side received AT‐ASCs single injection while the other received three sessions of FxCR. Scars were then assessed using the global scoring system Goodman and Baron, scar area percent using NIH ImageJ software and functional assessment by measuring the transepidermal water loss (TEWL) and skin hydration. Both sides were followed for three months. Results A significant improvement in the degree of scar severity, scar area percent, skin hydration, and TEWL after 3 months of treatment on both sides of the face with insignificant differences between both treatment modalities, provided that AT‐ASCs treatment was employed once vs. three sessions of FxCR. Conclusion One injection of AT‐ASCs is as effective as three sessions of FxCR in the treatment of atrophic acne scars.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 68%

Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

et al. 2019

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“…As described previously, AD-MSCs increase wound healing. Zhou et al showed the effectiveness of conditioned media of MSCs derived from adipose tissue in the treatment of 13 patients with atrophic acne scars [52]. They observed increased hydration and skin elasticity, higher concentration of dermal collagen and higher elastin density.…”

Section: Diseases Affecting Skinmentioning

confidence: 99%

Clinical application of AD-MSCs – A review

Semenova¹,

Chrościńska–Krawczyk²,

Grudniak³

et al. 2018

J Pre Clin Clin Res.

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Introduction. Mesenchymal stromal/stem cells (MSCs) are a unique type of stem cell which can be successfully used in regenerative medicine. They are safe, have the 'stem cell' ability of self-renewal and under appropriate conditions can differentiate into other types of cells without the problem of teratoma formation. MSCs express the characteristic phenotype (CD73ᶧ, CD90ᶧ, CD105ᶧ, CD14⁻, CD19⁻, CD34⁻, CD45⁻, HLA-DR⁻) and show immunosuppressive features, such as low expression of MHC I, lack of MHC II and secretion of a wide variety of immunoprotective cytokines and growth factors. One of the MSC sources is adipose tissue, which has some advantages compared with other existing sources. Currently, adipose tissue as a source of mesenchymal stromal/stem cells have become of interest due to a less invasive procedure of isolation and safety. This review contains data from various studies about the usage of adipose-derived MSCs in the treatment of different diseases. Objectives. The main aim of this review is evaluation of the useful characteristics of adipose-derived mesenchymal stem cells and their usage in stem cell treatment of some diseases. The aim is to describe the current knowledge and future perspectives. Conclusions. Adipose-derived MSCs (AD-MSCs) represent a good tool in regenerative stem cell therapy.

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“…Since survival, differentiation and fate of transplanted MSC remains undetermined, it is suggested that paracrine effects of MSC secretion are the primary mechanism for tissue regeneration (29). Recent studies have demonstrated the effect of ADMSC-CM on tissue regeneration (17,30,31). Research has shown that MSC-CM contains large amounts of cytokines that are involved in bone regeneration such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) (32).…”

Section: Introductionmentioning

confidence: 99%

Adipose Derived Stem Cells Conditioned Media in Combination with Bioceramic-Collagen Scaffolds Improved Calvarial Bone Healing in Hypothyroid Rats

Sanchooli

Norouzian

Ardeshirylajimi

et al. 2017

Iran Red Crescent Med J

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Background: Tissue engineering is an available treatment for large bone defects. The therapeutic effects of mesenchymal stem cell (MSC) are mostly attributed to secretion of many cytokines and growth factors. Many factors of MSC secretions accumulate in a conditioned medium and these factors recruit native cells into a defect site to generate new bone tissues. Objectives: The aim of this study was to evaluate the influence of adipose tissue derived MSCs-conditioned medium (ADMSC-CM) on bone repair of rats with critical -size calvarial defect. Methods: This experimental study was performed at Shahid Beheshti University of Medical Sciences, Tehran, Iran, from 2016 to 2017. Conditioned medium was collected from healthy rat adipose tissue derived MSC (ADMSC) at passage four. Calvarial bone defect was created in hypothyroid rats using a dental bur. Sampling was taken by the linear-mono-gram method to determine sample size (n = 6 per group). The rats were divided randomly into four groups based on graft material as follows: empty defect, scaffold (Bio-Oss / type I collagen gel), scaffold / ADMSCs, scaffold /ADMSC-CM. Evaluations were made at 4 and 8 weeks after surgery using stereological analysis. Results: Histological analysis at 8 weeks indicated that the newly regenerated tissue almost covered the defect in the ADMSC-CM group. Stereological analysis showed that ADMSC-CM increased regenerated bone and numbers of osteocytes and osteoblasts compared with the defect and scaffold groups (P < 0.05). Also, bone regeneration was more effective in animals treated with ADMSC-CM than in those received ADMSC. Conclusions: These results suggest an important role for ADMSC-CM in bone regeneration, through trophic impact of its cytokines and growth factors that induce native cell proliferation and migration into the defect. Thus, ADMSC-CM seems to have good potential for application in bone tissue regeneration, in the cases of hypothyroidism.

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The efficacy of conditioned media of adipose-derived stem cells combined with ablative carbon dioxide fractional resurfacing for atrophic acne scars and skin rejuvenation

Abstract: JSPH2012-082 - Registered 14 Feb 2012.

Cited by 68 publications

References 27 publications

Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

Clinical application of AD-MSCs – A review

Adipose Derived Stem Cells Conditioned Media in Combination with Bioceramic-Collagen Scaffolds Improved Calvarial Bone Healing in Hypothyroid Rats

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